Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. Explains biotechnology in a different light by using an application-oriented approach Discusses practical approaches in the development of precision medicine tools, systems and dynamical medicine approaches Promotes research in the field of biotechnology that is translational in nature, cost-effective and readily available to the community
Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.
Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are applied; from starting substrate to final product. A distinctive feature of this text are the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.
|Author||: Fazal Ahmad|
|Release Date||: 2012-12-02|
|ISBN 10||: 0323144616|
|Pages||: 612 pages|
From Gene to Protein: Translation into Biotechnology is the 15th volume in the continuing series under the title ""Miami Winter Symposia"". The theme of the symposium is the translation of the basic research findings into the practical application of biotechnology. This book summarizes methodology and its applications that lie behind the practical innovations. The book starts with reviews of techniques of eukaryotic cell culture, hybridoma technology and uses, and the in vitro synthesis of DNA and its use in the generation of protein analogs. Considerable space is devoted to development of monoclonal antibodies that promises to be the dominating tool of medical technology, both for diagnosis and therapy. Cloning into eukaryotic cells and methods of increasing the levels of gene expression are included. These topics reflect areas of intensive research that have important commercial and clinical value. Core chapters describe biological activities of cloned gene products, including reports on trials with human subjects of interferon, human insulin, and growth hormone. A panel session on horizons in biotechnology is also provided, looking forward to the directions of future research and its applications. Biotechnologists, cell biologists, scientists, researchers, teachers, and students will greatly benefit from this book.
Finally, the text includes a very thought-provoking chapter on the bioethics of these new advances and applications of today's world of biotechnology, which stimulates the student to think rather than memorize."--BOOK JACKET.
|Author||: Henry Daniell, Ph.D.,Christine D. Chase|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2007-11-04|
|ISBN 10||: 1402031661|
|Pages||: 659 pages|
We have taught plant molecular biology and biotechnology at the undergraduate and graduate level for over 20 years. In the past few decades, the field of plant organelle molecular biology and biotechnology has made immense strides. From the green revolution to golden rice, plant organelles have revolutionized agriculture. Given the exponential growth in research, the problem of finding appropriate textbooks for courses in plant biotechnology and molecular biology has become a major challenge. After years of handing out photocopies of various journal articles and reviews scattered through out the print and electronic media, a serendipitous meeting occurred at the 2002 IATPC World Congress held in Orlando, Florida. After my talk and evaluating several posters presented by investigators from my laboratory, Dr. Jacco Flipsen, Publishing Manager of Kluwer Publishers asked me whether I would consider editing a book on Plant Organelles. I accepted this challenge, after months of deliberations, primarily because I was unsuccessful in finding a text book in this area for many years. I signed the contract with Kluwer in March 2003 with a promise to deliver a camera-ready textbook on July 1, 2004. Given the short deadline and the complexity of the task, I quickly realized this task would need a co-editor. Dr. Christine Chase was the first scientist who came to my mind because of her expertise in plant mitochondria, and she readily agreed to work with me on this book.
|Author||: Guruprasad Madhavan,Barbara Oakley,Luis Kun|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2009-01-07|
|ISBN 10||: 9780387764955|
|Pages||: 536 pages|
This indispensable guide provides a roadmap to the broad and varied career development opportunities in bioengineering, biotechnology, and related fields. Eminent practitioners lay out career paths related to academia, industry, government and regulatory affairs, healthcare, law, marketing, entrepreneurship, and more. Lifetimes of experience and wisdom are shared, including "war stories," strategies for success, and discussions of the authors’ personal views and motivations.
Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.
Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ethics and safety concerns, along with in-depth examples of implications for human health and prospects for the future. New chapters cover animal biotechnology as applied to various disease types and research areas, including in vitro fertilization, human embryonic stem cell research, biosensors, enteric diseases, biopharming, organ transplantation, tuberculosis, neurodegenerative disorders, and more. Highlights the latest biomedical applications of genetically modified and cloned animals, with a focus on cancer and infectious diseases Offers first-hand accounts of the use of biotechnology tools, including molecular markers, stem cells, animal cultures, tissue engineering, ADME and CAM Assay Includes case studies that illustrate safety assessment issues, ethical considerations, and intellectual property rights associated with the translation of animal biotechnology studies
Plant Biotechnology provides an introduction to the fundamental life processes and reviews topics relevant to plant biotechnology. This book discusses the manipulation of biological systems to solve practical problems in industry or agriculture. Organized into four parts encompassing 18 chapters, this book begins with an overview of the fundamental techniques essential to plant biotechnology. This text then describes the various aspects of the regulation of gene expression in plants and reviews the molecular architecture of plant genes. Other chapters consider chloroplast genome from various organisms and present the practical examples of the significance and uses of biotechnology in crop improvement. This book discusses as well the methods for inducing plant gene expression in heterologous prokaryotic and eukaryotic systems. The final chapter deals with the potential for using gene transfer technology for crop improvement. This book is a valuable resource for plant physiologists, biochemists, plant scientists, genetic engineers, and evolutionary biologists.
This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.
Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students includes specific ‘product category chapters’ focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineering and how these drugs are developed. includes numerous relevant case studies to enhance student understanding no prior knowledge of protein structure is assumed
Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.
|Author||: International Association for Plant Tissue Culture & Biotechnology. International Congress,Fla.) International Association of Plant Tissue Culture and Biotechnology. International Congress (10th : 2002 : Orlando|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2003-01-31|
|ISBN 10||: 9781402011269|
|Pages||: 619 pages|
The 10th IAPTC&B Congress, Plant Biotechnology 2002 and Beyond, was held June 23-28, 2002, at Disney's Coronado Springs Resort, in Orlando, Florida, USA. It was attended by 1,176 scientists from 54 countries. The best and brightest stars of international plant biotechnology headlined the scientific program. It included the opening address by the President of the IAPTC&B, 14 plenary lectures, and 111 keynote lectures and contributed papers presented in 17 symposia covering all aspects of plant biotechnology. More than 500 posters supplemented the formal program. The distinguished speakers described, discussed and debated not only the best of science that has been done or is being done, but also how the power of plant biotechnology can be harnessed to meet future challenges and needs. The program was focused on what is new and what is exciting, what is state of the art, and what is on the cutting edge of science and technology. In keeping with the international mandate of the IAPTC&B, 73 of the 125 speakers were from outside the United States, representing 27 countries from every region of the world. The 10th IAPTC&B Congress was a truly world-class event. The IAPTC&B, founded in 1963 at the first international conference of plant tissue culture organized by Philip White in the United States, currently has over 1,500 members in 85 countries. It is the largest, oldest, and the most comprehensive international professional organization in the field of plant biotechnology. The IAPTC&B has served the plant biotechnology community well through its many active national chapters throughout the World, by maintaining and disseminating a membership list and a website, by the publication of an official journal (formerly the Newsletter), and by organizing quadrennial international congresses in France (1970), the United Kingdom (1974), Canada (1978), Japan (1982), the United States (1963, 1986, 2002), The Netherlands (1990), Italy (1994), and Israel (1998). In addition, the IAPTC&B has a long tradition of publishing the proceedings of its congresses. Individually, these volumes have provided authoritative quadrennial reports of the status of international plant biotechnology. Collectively, they document the history of plant biotechnology during the 20th century. They are indeed a valuable resource. We are pleased to continue this tradition by publishing this proceedings volume of the 10th IAPTC&B Congress. Regrettably, we are not able to publish seven of the lectures in full (only their abstracts are included). The American and Canadian chapters of the IAPTC&B, the Plant Section of the Society for In Vitro Biology, and the University of Florida hosted the 10th IAPTC&B Congress. The Congress was a true partnership between academia and industry, and was generously supported by both groups (see list of donors/sponsors on back cover). A number of prominent international biotechnology companies and publishers participated in the very successful Science and Technology Exhibit (see accompanying list of exhibitors) The IAPTC&B awarded 84 fellowships to young scientists from 31 countries (see accompanying list of fellowship recipients) to support their participation in the Congress.
Biotechnology is a diverse, complex and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. Volumes containing competent reviews on a diverse range of topics in the field fulfill the dual role of broadening and updating biotechnologists’ knowledge. The current volume is an excellent example of such a book. The topics covered range from classical issues in biotechnology - such as, recent advances in all-protein chromophore technology- to topics that are focused on sequencing and recombinant vaccines. The information presented in this book will therefore will be of great value to both experienced biotechnologists and biotechnologists in training. * Includes over 200 figures with more than 60 tables * Discusses valuable information on pharming & transgenic plants * Provides detailed information on the production of plasmid DNA for pharmaceutical use
|Author||: Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials|
|Publisher||: National Academies Press|
|Release Date||: 2012-09-13|
|ISBN 10||: 0309224187|
|Pages||: 354 pages|
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
This series is designed for junior undergraduates and diploma students in all biological sciences, covering the field of modern biochemistry and integrating animal, plant and microbial topics. This volume focuses on the nature and behaviour of genetic material.
|Author||: Hansjörg Hauser,Roland Wagner|
|Publisher||: Walter de Gruyter|
|Release Date||: 1997-01-01|
|ISBN 10||: 3110809281|
|Pages||: 510 pages|
„Hauser und Wagner haben die neuen Möglichkeiten der Mammalian Cell Biology sehr anregend dargestellt.“ Prof. Dr. Hans Fritz, Ludwig-Maximilians-Universität München
This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.