total synthesis of bioactive natural products

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Total Synthesis of Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : Elsevier
Release Date : 2019-04-27
ISBN 10 : 0081028237
Pages : 350 pages
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Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Total Synthesis of Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : Elsevier
Release Date : 2019-06-15
ISBN 10 : 9780081028223
Pages : 310 pages
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Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
Author : Shinsuke Inuki
Publisher : Springer Science & Business Media
Release Date : 2011-11-23
ISBN 10 : 9784431540434
Pages : 106 pages
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The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Isolation, Structure Elucidation, and Total Synthesis of Bioactive Natural Products
Author : Roberto Forestieri
Publisher : N.A
Release Date : 2013
ISBN 10 :
Pages : 329 pages
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Multicomponent Reactions
Author : K.L. Ameta, Ph.D.,Anshu Dandia
Publisher : CRC Press
Release Date : 2017-09-20
ISBN 10 : 1315352737
Pages : 394 pages
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This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.

Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Release Date : 2015-03-23
ISBN 10 : 3527337946
Pages : 544 pages
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Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Studies in Natural Products Chemistry
Author : Atta-ur Rahman
Publisher : Elsevier
Release Date : 2012
ISBN 10 : 0444595147
Pages : 421 pages
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry

Studies in Natural Products Chemistry
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 2002-03-01
ISBN 10 : 9780080542065
Pages : 1364 pages
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Bioactive Natural Products (Part G)

Bioactive Natural Products
Author : Atta-ur- Rahman
Publisher : Elsevier Science Limited
Release Date : 1988
ISBN 10 :
Pages : 1347 pages
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Cover -- Contents -- Foreword -- Preface -- Contributors -- Chapter 1. Acid-catalysed epimerization of bioactive indole alkaloids and their derivatives -- Chapter 2. Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols fiom plants and fungi -- Chapter 3. Bioactive oleanene glucuronides obtained from fabaceous plants -- Chapter 4. Biotransformation of terpenoids by microorganisms -- Chapter 5. Cycloartane and oleanane saponins from Astragalus sp. -- Chapter 6. Labdane-type diterpenes: Chemistry and biological activity -- Chapter 7. Metabolism of the tomato saponin a-tomatine by phytopathogenic fungi -- Chapter 8. Heme aggregation inhibitors: Antimalarial drugs targeting an essential biomineralization process -- Chapter 9. Bioactive peptides as signal molecules in plant defense, growth and development -- Chapter 10. Enzymes involved in the biosynthesis of brassinosteroids -- Chapter 11. Immunopotentiating effects of a glycoprotein from Chlorella vulgaris stra ...

The Claisen Rearrangement
Author : Martin Hiersemann,Udo Nubbemeyer
Publisher : John Wiley & Sons
Release Date : 2007-02-27
ISBN 10 : 3527610553
Pages : 591 pages
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The first comprehensive coverage of all facets of the Claisen rearrangement and its variants. As such, this book helps synthetic chemists to exploit the vast potential of this elegant C-C linking reaction, discusses a wealth of catalytic options, and gives those more theory-minded chemists a detailed insight into the mechanistic aspects of the Claisen rearrangement. An invaluable source of information and a ready reference for all organic and catalytic chemists, as well as those working with/on organometallics, and in industry.

Studies in Natural Products Chemistry
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 1996-05-01
ISBN 10 : 9780080541778
Pages : 1108 pages
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In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity. The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, ä-lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.

Bioactive Marine Natural Products
Author : Dewan S. Bhakuni,D.S. Rawat
Publisher : Springer Science & Business Media
Release Date : 2006-06-30
ISBN 10 : 1402034849
Pages : 382 pages
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Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.

Macrocycles in Drug Discovery
Author : Jeremy I Levin
Publisher : Royal Society of Chemistry
Release Date : 2014-10-16
ISBN 10 : 1849737010
Pages : 499 pages
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This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.

Bioactive Natural Products (Part E)
Author : Atta-ur-Rahman
Publisher : Elsevier Science Serials
Release Date : 1988
ISBN 10 :
Pages : 1170 pages
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

Synthetic Studies on Bioactive Natural Products
Author : Joji Hayashida
Publisher : Proquest, UMI Dissertation Publishing
Release Date : 2011-09
ISBN 10 : 9781243616609
Pages : 396 pages
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The synthetic studies toward the total syntheses of recently isolated bioactive natural products, haouamine A, platensimycin and platencin were investigated. During the course study of a new alkaloid, haouamine A, we have developed a simple synthetic route of chiral 2-substituted-3-piperidinones by utilizing a sequential regioselective proline-mediated aldol condensation and rhodium-catalyzed asymmetric hydrogenation. The model studies on aza-[7]-paracyclophane moiety of haouamine A were also examined with the strategies involving in Diels-Alder reaction, Ramberg-Backlund Reaction, cyclotrimerization, and Danheiser Benzannulation. In the studies of platensimycin and platencin, we intended to apply the pseudo-biomimeric cyclization strategy for the introduction of their characteristic bicyclo[2.3.1]octane and bicyclo[2.2.2]octane bridgehead structures. As a result, we have accomplished the concise total synthesis of platencin from commercially available o-anisic acid in 14 steps with 3.5% overall yield. During the course of this investigation, we developed a convenient method to synthesize the two distinctive cis-decalines containing a chiral quaternary carbon center through Diels-Alder reaction by utilizing two different sizes of amino-siloxyl dienes. We also found the modification of nickel mediated conjugate addition, discovered an unprecedented chemical reactivity of vinylsilane under oxidation condition with iodosobenzene and hydrogen peroxide, and demonstrated the biomimeric protective group free coupling strategy.

Medicinal Chemistry of Bioactive Natural Products
Author : Xiao-Tian Liang,Wei-Shuo Fang
Publisher : John Wiley & Sons
Release Date : 2006-03-17
ISBN 10 : 0471739332
Pages : 336 pages
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Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

Microbial Reagents in Organic Synthesis
Author : S. Servi
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
ISBN 10 : 9401124442
Pages : 490 pages
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Proceedings of the NATO Advanced Research Workshop, Sestri Levante, Italy, March 23-27, 1992

Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Release Date : 2015-01-20
ISBN 10 : 3527684425
Pages : 544 pages
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Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

The Role of Natural Products in Drug Discovery
Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Release Date : 2013-04-17
ISBN 10 : 3662040425
Pages : 351 pages
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Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Bioactive Natural Products (Part E)
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 2000-12-22
ISBN 10 : 9780080542003
Pages : 1170 pages
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.