therapeutic drug monitoring data

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Therapeutic Drug Monitoring Data
Author : Amitava Dasgupta,Matthew Krasowski
Publisher : Academic Press
Release Date : 2019-09-14
ISBN 10 : 0128158506
Pages : 382 pages
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Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Therapeutic Drug Monitoring Data
Author : Amitava Dasgupta,Matthew Krasowski
Publisher : Academic Press
Release Date : 2019-09-14
ISBN 10 : 0128158506
Pages : 382 pages
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Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Author : Georg Hempel
Publisher : Elsevier
Release Date : 2019-10-17
ISBN 10 : 0444640673
Pages : 380 pages
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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Therapeutic Drug Monitoring
Author : Amitava Dasgupta
Publisher : Academic Press
Release Date : 2012-06-07
ISBN 10 : 0123854687
Pages : 468 pages
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Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Drug Monitoring and Clinical Chemistry
Author : Georg Hempel
Publisher : Elsevier
Release Date : 2004-05-15
ISBN 10 : 0080530540
Pages : 378 pages
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Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

Clinical Challenges in Therapeutic Drug Monitoring
Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Release Date : 2016-07-21
ISBN 10 : 0128020520
Pages : 376 pages
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Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Author : Georg Hempel
Publisher : Elsevier
Release Date : 2019-10-17
ISBN 10 : 0444640673
Pages : 380 pages
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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Handbook of Drug Monitoring Methods
Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Release Date : 2007-10-23
ISBN 10 : 1588297802
Pages : 445 pages
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In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

The Immunoassay Handbook
Author : David Wild
Publisher : Newnes
Release Date : 2013-01-21
ISBN 10 : 0080970389
Pages : 1036 pages
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The fourth edition of The Immunoassay Handbook provides an excellent, thoroughly updated guide to the science, technology and applications of ELISA and other immunoassays, including a wealth of practical advice. It encompasses a wide range of methods and gives an insight into the latest developments and applications in clinical and veterinary practice and in pharmaceutical and life science research. Highly illustrated and clearly written, this award-winning reference work provides an excellent guide to this fast-growing field. Revised and extensively updated, with over 30% new material and 77 chapters, it reveals the underlying common principles and simplifies an abundance of innovation. The Immunoassay Handbook reviews a wide range of topics, now including lateral flow, microsphere multiplex assays, immunohistochemistry, practical ELISA development, assay interferences, pharmaceutical applications, qualitative immunoassays, antibody detection and lab-on-a-chip. This handbook is a must-read for all who use immunoassay as a tool, including clinicians, clinical and veterinary chemists, biochemists, food technologists, environmental scientists, and students and researchers in medicine, immunology and proteomics. It is an essential reference for the immunoassay industry. Provides an excellent revised guide to this commercially highly successful technology in diagnostics and research, from consumer home pregnancy kits to AIDS testing. www.immunoassayhandbook.com is a great resource that we put a lot of effort into. The content is designed to encourage purchases of single chapters or the entire book. David Wild is a healthcare industry veteran, with experience in biotechnology, pharmaceuticals, medical devices and immunodiagnostics, which remains his passion. He worked for Amersham, Eastman-Kodak, Johnson & Johnson, and Bristol-Myers Squibb, and consulted for diagnostics and biotechnology companies. He led research and development programs, design and construction of chemical and biotechnology plants, and integration of acquired companies. Director-level positions included Research and Development, Design Engineering, Operations and Strategy, for billion dollar businesses. He retired from full-time work in 2012 to focus on his role as Editor of The Immunoassay Handbook, and advises on product development, manufacturing and marketing. Provides a unique mix of theory, practical advice and applications, with numerous examples Offers explanations of technologies under development and practical insider tips that are sometimes omitted from scientific papers Includes a comprehensive troubleshooting guide, useful for solving problems and improving assay performancee Provides valuable chapter updates, now available on www.immunoassayhandbook.com

Neuropsychiatric Disorders
Author : Manfred Gerlach,Jürgen Deckert,Kay Double,Eleni Koutsilieri
Publisher : Springer Science & Business Media
Release Date : 2007-12-28
ISBN 10 : 9783211735749
Pages : 341 pages
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This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Interpretation of Equine Laboratory Diagnostics
Author : Nicola Pusterla,Jill Higgins
Publisher : John Wiley & Sons
Release Date : 2017-12-18
ISBN 10 : 1118739795
Pages : 448 pages
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Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to establish and new diagnostic procedures Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring
Author : Amitava Dasgupta
Publisher : CRC Press
Release Date : 2009-10-06
ISBN 10 : 1420067591
Pages : 475 pages
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For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for imp

Analytical Methods for Therapeutic Drug Monitoring and Toxicology
Author : Q. Alan Xu,Timothy L. Madden
Publisher : John Wiley & Sons
Release Date : 2011-04-12
ISBN 10 : 9780470922798
Pages : 520 pages
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This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Mosby's Canadian Manual of Diagnostic and Laboratory Tests - E-Book
Author : Kathleen Deska Pagana,Timothy J. Pagana,Sandra A. Pike-MacDonald
Publisher : Elsevier Health Sciences
Release Date : 2012-09-14
ISBN 10 : 1927406889
Pages : 1368 pages
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The very first resource of its kind, written exclusively for Canada, Mosby’s Canadian Manual of Diagnostic and Laboratory Tests provides clear, concise coverage of more than 700 of the most commonly performed tests, with Canadian lab values, SI units, Canadian cultural considerations, and more unique Canadian content. Its many user-friendly features include an easy-to-understand writing style, full-colour illustrations, and a logical organization. Each test entry is presented in a consistent format to provide quick access to information on specimen collection, normal findings, indications, test explanation, procedure and patient care, and test results and clinical significance, as well as any applicable contraindications, potential complications, interfering factors, and related tests. UNIQUE! Test Results and Clinical Significance sections explain pathophysiology and how test results may indicate certain disease processes. Critical values are emphasized to alert you to situations requiring immediate intervention. UNIQUE! Related Tests sections list tests that provide similar information or are used to evaluate the same body system, disease process, or symptom. UNIQUE! SI units in the Normal Findings section of appropriate tests offer quick and easy reference (conventional units also included). UNIQUE! Cultural Considerations boxes highlight important aspects of working with people from the diverse cultural and racial backgrounds of the Canadian population, such as First Nations communities. Includes Canadian generic and trade drug names to comply with Health Canada and the Compendium of Pharmaceuticals and Specialties (CPS). Addresses Canadian privacy laws and legislation (including PHIPA and PIPEDA), the Canadian Labour Code, and policies for DNA collection, reporting of infections such as Chlamydia, and much more. Provides information on Canadian test-tube colouring classifications and guidelines for the correct order and process of collecting blood samples in Canada. Follows Canadian standard precautions and procedures such as those set forth by the Canadian Nuclear Safety Commission, as well as Canadian screening protocols such as those set out in the Canadian Cancer Society Screening Guidelines. Canadian statistics are provided for topics such as STDs and C. difficile. New full-colour photographs and enhanced illustrations clarify key concepts and reflect the latest procedures, equipment, and techniques. Completely updated content covers 30 new tests, including ductoscopy, thyroglobulin, lactoferrin, and human papillomavirus.

Interpretations in Therapeutic Drug Monitoring
Author : Daniel M. Baer,William R. Dito
Publisher : Amer Society of Clinical
Release Date : 1981
ISBN 10 :
Pages : 388 pages
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Clinical Biochemistry E-Book
Author : William J. Marshall,Márta Lapsley,Andrew Day,Ruth Ayling
Publisher : Elsevier Health Sciences
Release Date : 2014-03-05
ISBN 10 : 070205478X
Pages : 996 pages
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Essential reading for candidates for the MRCPath examination and similar postgraduate examinations in clinical biochemistry. The book gives an overview of the acquisition of data, as well as concentrating on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management. In common with other diagnostic specialties clinical biochemistry now uses an increasing number of techniques involving the 'new biology': these are covered in this book. It is also increasingly common for medically qualified clinical biochemists to become involved in the clinical management of patients (eg nutritional support) and material on this will be included. From the author of the popular Clinical Chemistry medical student textbook. Although there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical. Ideally suited for preparation for the MRCPath and similar examination. Significant changes to content to reflect changes in how clinical chemistry services are organised and to reflect the advent of metabolic medicine as a recognised specialty. Chapter on Clinical biochemistry of nutrition to include new information on regulation of appetite and the clinical management of obesity. New chapter to bring together information on inborn errors of metabolism affecting adults. New chapter on clinical biochemistry of cardiovascular disease. The diabetes chapter has been split into two separate chapters to allow more detailed description of the practical clinical management of the disease.

Mosby's Diagnostic and Laboratory Test Reference - eBook
Author : Kathleen Deska Pagana,Timothy J. Pagana
Publisher : Elsevier Health Sciences
Release Date : 2010-11-16
ISBN 10 : 0323080146
Pages : 1152 pages
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Access the clinically relevant information you need easily in any setting with Mosby's Diagnostic and Laboratory Test Reference, 10th Edition. This bestselling handbook provides concise coverage of tests without sacrificing important details. Each test entry includes, where relevant, alternate or abbreviated test names; type of test; normal findings; possible critical values; test explanation and related physiology; contraindications; potential complications; interfering factors; procedure and patient care (before, during, and after); and abnormal findings. Related tests are extensively cross-referenced throughout the book. With its simple format and portable size, this is a handy reference you'll always want by your side. Tests are organized alphabetically with A-to-Z thumb tabs for quick reference. UNIQUE! Each test entry begins on a new page, making tests easy to find. Normal findings for adult (male and female), elderly, and pediatric patients are included where applicable to provide complete clinical data. Possible critical values are highlighted to alert you to situations requiring immediate intervention. Symbol next to drug-related interfering factors alerts you to the effects of pharmacologic agents on tests. Increased and decreased abnormal findings are highlighted with directional arrows. Icon for patient teaching-related care indicates information to share with patients and their families. UNIQUE! Each test concludes with a Notes section where you can add your own information. User's Guide to Test Preparation and Performance provides an overview and guidelines for each type of laboratory test and diagnostic procedure to ensure safety and accuracy. Lists of tests by body system and test type allow you to quickly locate related studies. Abbreviations for tests are listed inside the front and back covers, and symbols and units of measurement are listed in an appendix. UNIQUE! Durable cover with round edges helps prevent the book from being damaged and makes it easier to handle. ~ 32 NEW tests, including age-related macular degeneration risk analysis, cell culture drug resistance testing, flourescein angiography, HIV drug resistance testing, urea breath test, virus testing, and Vitamin D testing, present the latest information on diagnostic and laboratory testing.

Small Animal Clinical Pharmacology and Therapeutics - E-Book
Author : Dawn Merton Boothe
Publisher : Elsevier Health Sciences
Release Date : 2011-07-25
ISBN 10 : 1437723578
Pages : 1348 pages
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Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions. Comprehensive approach emphasizes the use of drugs for prevention as well as treatment. Clear, consistent organization makes it easy to find the information you need when you need it. Dosage tables help you find essential pharmaceutical information at a glance. Pharmacogenetics chapter helps you understand how to use this emerging science to find the right dose for each patient, optimizing efficiency and minimizing toxicity. Routes of administration and sample pharmaceutical calculations provide fast, efficient access to comprehensive drug administration all in one inclusive resource. Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.

Applied Therapeutic Drug Monitoring: Fundamentals
Author : Thomas P. Moyer,Roger L. Boeckx
Publisher : AACC Press
Release Date : 1982
ISBN 10 :
Pages : 239 pages
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Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring
Author : Amitava Dasgupta
Publisher : John Wiley & Sons
Release Date : 2012-07-02
ISBN 10 : 1118347854
Pages : 472 pages
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The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: False positive results in immunoassays for drugs in abuse testing Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin False positive alcohol tests using breath analyzers and automated analyzers When a toxicology report is negative in a suspected overdose patient: the world of designer drugs Effects of drug-herb interactions on therapeutic drug monitoring Pharmacogenomics and the general principles of genetic analysis Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.