the preclinical and clinical effects of cannabis and cannabinoids on cardiovascular health

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The Preclinical and Clinical Effects of Cannabis and Cannabinoids on Cardiovascular Health
Author : Rodney A. Samaan,Christopher Samaan
Publisher : Academic Press
Release Date : 2021-08-16
ISBN 10 : 9780128174326
Pages : 308 pages

The Preclinical and Clinical Effects of Cannabis and Cannabinoids on Cardiovascular Health is a comprehensive investigation into the cardiovascular health effects of marijuana use. As the prevalence of cannabis use increases both recreationally and clinically, a shroud of misinformation exists in academia, the public, and clinical realms. Further, since different studies show contradictory results it is hard to determine the exact benefits for cannabis use. This book will focus on a specific set of cardiovascular diseases plaguing the current population and the effects of cannabis will be addressed from numerous viewpoints including human physiological and clinical disease outcomes to issues in public health. By gathering this information in a way that addresses numerous viewpoints the book serves as a comprehensive reference and clinical guide Compiles the numerous contradictory reports about the effects of marijuana and cardiovascular disease for ease in comparison Examines the mechanisms that have shown how marijuana use might contribute to the development of chronic cardiovascular conditions and/or acutely trigger cardiovascular events Includes coverage of the drug's role in pharmacotherapy

The Health Effects of Cannabis and Cannabinoids
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda
Publisher : National Academies Press
Release Date : 2017-03-31
ISBN 10 : 0309453070
Pages : 486 pages

Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

The Health and Social Effects of Nonmedical Cannabis Use
Author : World Health Organization
Publisher : World Health Organization
Release Date : 2016-02-15
ISBN 10 : 9241510242
Pages : 95 pages

Cannabis is globally the most commonly used psychoactive substance under international control. In 2013, an estimated 181.8 million people aged 15-64 years used cannabis for nonmedical purposes globally (UNODC, 2015). There is an increasing demand for treatment for cannabis-use disorders and associated health conditions in high- and middle-income countries. This report focuses on nonmedical use of cannabis, building on contributions from a broad range of experts and researchers from different parts of the world. It aims to present current knowledge on the impact of nonmedical cannabis use on health, from its impact on brain development to its role in respiratory diseases. The potential medical utility of cannabis -- including the pharmacology, toxicology and possible therapeutic applications of the cannabis plant -- is outside the scope of this report.

Cannabis Healing
Author : Franjo Grotenhermen
Publisher : Simon and Schuster
Release Date : 2020-09-22
ISBN 10 : 1620558327
Pages : 240 pages

Everything you need to know to use cannabinoids safely and effectively for better health and healing of a wide range of conditions • Explains the biochemistry of cannabinoids and shows how they interact with the human body • Offers a complete discussion of safe use, possible side effects, contraindications, and precautions, including during pregnancy and chemotherapy • Explores the use of CBD to treat seizures, anxiety, muscular disorders, and psychotic states and the use of THC to treat schizophrenia, Alzheimer’s, ADHD, Tourette’s, Parkinson’s, depression, COPD, and chronic pain, among many other physical, neurological, and emotional conditions In this authoritative yet practical guide to the healing properties of cannabis and cannabinoids such as THC and CBD, Franjo Grotenhermen, M.D., explores how to use these substances to treat a wide range of physical and emotional conditions. Dr. Grotenhermen first examines the history of marijuana as medicine, including its important role in U.S. medical practice during the 19th century. He explains the biochemistry of cannabinoids and shows how they interact with the human body, including a look at cannabinoid receptors and how cannabinoids occur naturally in the body. The author then draws on his years of experience legally treating patients in Germany as well as numerous research studies and tests to provide an in-depth guide to the many healing applications for cannabis and its derivatives. The therapeutic applications covered include the use of CBD to treat seizures, epilepsy, anxiety, several forms of cancer, muscular disorders, and psychotic states and the use of THC to treat schizophrenia, Alzheimer’s, ADHD, Tourette’s, Parkinson’s, impotence, depression, lupus, COPD, and chronic pain, among many other physical, neurological, and emotional conditions. The author examines the various cannabis-derived medications available, such as Cannabinol, Dronabinol, and Marinol, and the main methods of administering cannabis. He offers a complete discussion of safe use, possible side effects, contraindications, and precautions (including during pregnancy and chemotherapy), alongside research data that confirms cannabis as one of the least toxic substances in existence. Written by a practicing physician, this guide provides everything you need to know to use cannabinoids safely and effectively for health and healing.

Handbook of Cannabis and Related Pathologies
Author : Victor R. Preedy
Publisher : Academic Press
Release Date : 2016-12-31
ISBN 10 : 012800827X
Pages : 1170 pages

Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug’s effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points Presents illustrations with at least six figures, tables, and diagrams per chapter Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse

Marijuana and Medicine
Author : Institute of Medicine
Publisher : National Academies Press
Release Date : 1999-07-10
ISBN 10 : 0309071550
Pages : 288 pages

The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicine--the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Handbook of Cannabis
Author : Roger G. Pertwee
Publisher : Oxford University Press, USA
Release Date : 2014
ISBN 10 : 0199662681
Pages : 747 pages

In addition it also examines the complex morphology, cultivation, harvesting, and processing of cannabis and the ways in which the plant's chemical composition can be controlled. As well as offering a raft of scientific information there is extensive coverage of cannabinoid-based medicines. Helping readers to identify and evaluate their benefits, chapters explore pharmacological actions and the effects that seem to underlie approved therapeutic uses, how they are currently used to treat certain disorders, and the ever-growing number of wide-ranging potential clinical applications. There is also coverage of both the legal and illegal sources of cannabis, including 'coffee shops' and 'cannabis dispensaries'. The complex issue of 'recreational cannabis' is also tackled.

Cannabis and Cannabinoids
Author : Ethan B Russo
Publisher : Routledge
Release Date : 2013-09-05
ISBN 10 : 1136614931
Pages : 478 pages

Study the latest research findings by international experts! This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world’s foremost researchers. Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana’s use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine. Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effects Cannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.

Marijuana and the Cannabinoids
Author : Mahmoud A. ElSohly
Publisher : Springer Science & Business Media
Release Date : 2007-11-15
ISBN 10 : 1592599478
Pages : 322 pages

Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.

Cannabinoids in Health and Disease
Author : Rosaria Meccariello,Rosanna Chianese
Publisher : BoD – Books on Demand
Release Date : 2016-06-15
ISBN 10 : 9535124293
Pages : 258 pages

This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.

The Health Effects of Cannabis
Author : Harold Kalant,Centre for Addiction and Mental Health
Publisher : Addiction Research Foundation
Release Date : 1999
ISBN 10 : 9780888683250
Pages : 526 pages

The Health Effects of Cannabis is a definitive reference text on the adverse, and also the potentially beneficial, effects of cannabis use. Internationally recognized experts in the field contribute a wealth of information about the use and effects of Canada's most widely used illicit drug. The Health Effects of Cannabis will be of interest to addiction medicine specialists, educators, researchers, health program managers and policy-makers, and anyone else who wants scientific information on cannabis and its effects. Topics include: the epidemiology of cannabis use and related problems the long-term central nervous system effects of cannabis mental and behavioural disorders caused by cannabis use cannabis and immunity cannabis use during pregnancy therapeutic uses of cannabis and cannabinoids the health and psychological effects of cannabis use the comparative risks of alcohol, tobacco, cannabis and opioid use.

Cannabinoids in Neurologic and Mental Disease
Author : Liana Fattore
Publisher : Academic Press
Release Date : 2015-01-23
ISBN 10 : 0124171249
Pages : 496 pages

The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neuroinflammatory disease. The neurologic application of cannabinoid therapy builds upon psychiatric and psychological use for the treatment of a variety of core mental disorders. This comprehensive reference on the known uses of cannabinoids will be useful for clinical neurologists, neuroscience and clinical neuroscience researchers, clinical psychologists and psychiatrists and the general medical community. A comprehensive reference on the clinical uses of cannabinoids for treating major neurologic and mental diseases Detailed coverage of cannabinoid use for neuroinflammatory and neurodegenerative disease including Multiple Sclerosis, Epilepsy, Huntington's disease, Parkinson's disease, and Alzheimer's disease Detailed coverage of cannabinoid use for major psychiatric and psychological diseases and disorders including schizophrenia, bipolar disorders, Tourette's syndrome, and post-traumatic stress disorder (PTSD)