the mechanics of inhaled pharmaceutical aerosols

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The Mechanics of Inhaled Pharmaceutical Aerosols
Author : Warren H. Finlay
Publisher : Academic Press
Release Date : 2019-06-01
ISBN 10 : 0081027869
Pages : 302 pages

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Exam Prep for: The Mechanics of Inhaled Pharmaceutical Aerosols
Author : N.A
Publisher : N.A
Release Date :
ISBN 10 :
Pages : 329 pages

Pharmaceutical Inhalation Aerosol Technology, Second Edition
Author : Anthony J. Hickey
Publisher : CRC Press
Release Date : 2003-09-03
ISBN 10 : 9780824756642
Pages : 288 pages

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Inhalation Aerosols
Author : Anthony J. Hickey,Heidi M. Mansour
Publisher : CRC Press
Release Date : 2019-03-21
ISBN 10 : 1351660519
Pages : 417 pages

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Inhaled Pharmaceutical Product Development Perspectives
Author : Anthony J. Hickey
Publisher : Elsevier
Release Date : 2017-11-23
ISBN 10 : 0128123362
Pages : 110 pages

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

Pharmaceutical Inhalation Aerosol Technology, Third Edition
Author : Anthony J. Hickey,Sandro R. da Rocha
Publisher : CRC Press
Release Date : 2019-03-26
ISBN 10 : 0429619561
Pages : 730 pages

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Controlled Pulmonary Drug Delivery
Author : Hugh D.C. Smyth,Anthony J. Hickey
Publisher : Springer Science & Business Media
Release Date : 2011-06-24
ISBN 10 : 9781441997456
Pages : 558 pages

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Aerosol Science
Author : Ian Colbeck,Mihalis Lazaridis
Publisher : John Wiley & Sons
Release Date : 2014-01-30
ISBN 10 : 1118675355
Pages : 496 pages

Aerosols influence many areas of our daily life. They are at the core of environmental problems such as global warming, photochemical smog and poor air quality. They can also have diverse effects on human health, where exposure occurs in both outdoor and indoor environments. However, aerosols can have beneficial effects too; the delivery of drugs to the lungs, the delivery of fuels for combustion and the production of nanomaterials all rely on aerosols. Advances in particle measurement technologies have made it possible to take advantage of rapid changes in both particle size and concentration. Likewise, aerosols can now be produced in a controlled fashion. Reviewing many technological applications together with the current scientific status of aerosol modelling and measurements, this book includes: • Satellite aerosol remote sensing • The effects of aerosols on climate change • Air pollution and health • Pharmaceutical aerosols and pulmonary drug delivery • Bioaerosols and hospital infections • Particle emissions from vehicles • The safety of emerging nanomaterials • Radioactive aerosols: tracers of atmospheric processes With the importance of this topic brought to the public’s attention after the eruption of the Icelandic volcano Eyjafjallajökull, this book provides a timely, concise and accessible overview of the many facets of aerosol science.

Aerosols Handbook
Author : Lev S. Ruzer,Naomi H. Harley
Publisher : CRC Press
Release Date : 2004-12-28
ISBN 10 : 9780203493182
Pages : 728 pages

As more attention is dedicated to understanding the occupational health risks associated with the industrial manufacture and use of nanotechnology, Aerosols Handbook: Measurement, Dosimetry, and Health Effects is a timely presentation of time-tested research in the field of aerosol science. The book covers a multitude of topics in indoor, outdoor,

Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products
Author : Terrence P. Tougas,Jolyon P. Mitchell,Svetlana A. Lyapustina
Publisher : Springer Science & Business Media
Release Date : 2013-04-10
ISBN 10 : 1461462967
Pages : 442 pages

The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

Delivery Systems for Tuberculosis Prevention and Treatment
Author : Anthony J. Hickey
Publisher : John Wiley & Sons
Release Date : 2016-08-25
ISBN 10 : 1118943201
Pages : 456 pages

Provides a review of novel pharmaceutical approaches for Tuberculosis drugs Presents a novel perspective on tuberculosis prevention and treatment Considers the nature of disease, immunological responses, vaccine and drug delivery, disposition and response Multidisciplinary appeal, with contributions from microbiology, immunology, molecular biology, pharmaceutics, pharmacokinetics, chemical and mechanical engineering

Essentials of Cardiopulmonary Physical Therapy - E-Book
Author : Ellen Hillegass,H. Steven Sadowsky
Publisher : Elsevier Health Sciences
Release Date : 2010-12-23
ISBN 10 : 1437703836
Pages : 784 pages

Based on best practices prescribed in The Guide to Physical Therapist Practice, Essentials of Cardiopulmonary Physical Therapy, 3rd Edition provides comprehensive coverage of anatomy and physiology, assessment, and aspects of the cardiopulmonary systems, with a focus on their interaction. The disablement model is used in describing the eight cardiopulmonary practice patterns. Expert author Ellen Hillegass also discusses pathophysiology, pharmacology, and interventions in the outpatient setting. Incorporating Guide language, her practical approach progresses logically from basic sciences through intervention, and emphasizes lifespan considerations. Material follows The Guide to Physical Therapist Practice 2nd Edition, reflecting best practices as defined by the American Physical Therapy Association. Evidence-based content is based on the latest research in the field. Case studies show the application of concepts with real-world examples. Pharmacology chapters reflect both the rehabilitation background of physical therapists and the pharmaceutical expertise of a pharmacist. A focus on wellness follows the disablement model. Information on geriatric and pediatric cardiopulmonary physical therapy is easy to apply to patient situations. Testing for both cardiac and pulmonary dysfunction is conveniently located in a single chapter. Cardiovascular medication information covers the latest drugs used in cardiopulmonary physical therapy. Information on thoracic organ transplantation simplifies and explains these complex procedures. NEW chapters cover the lymphatic system and pediatrics. Revised chapters on cardiopulmonary anatomy and physiology differentiate between information that is need to know and that is nice to know. An Evolve companion website includes medical animations to illustrate concepts, along with a glossary, glossary exercises, and reference lists from the book linked to MEDLINE abstracts.

Author : Konstantin Volkov
Publisher : BoD – Books on Demand
Release Date : 2016-12-28
ISBN 10 : 9535128434
Pages : 206 pages

Aerosols have a significant impact on technological processes and human activities. In many cases, aerosols are at the core of human health, environmental and technological problems (climate change and air quality). However, aerosols can be successfully used in industry and technology (new materials, fire suppression and fuel delivery). The current scientific status of aerosol modelling and simulation and measurements and some advances in computational techniques, particle measurement technologies and practical applications of aerosols are reviewed and considered in this book. This book also includes a number of case studies focused on analysis of optical thickness and air quality in various regions.

Aerosol Measurement
Author : Pramod Kulkarni,Paul A. Baron,Klaus Willeke
Publisher : John Wiley & Sons
Release Date : 2011-09-09
ISBN 10 : 9781118001677
Pages : 900 pages

Aerosol Measurement: Principles, Techniques, and Applications Third Edition is the most detailed treatment available of the latest aerosol measurement methods. Drawing on the know-how of numerous expert contributors; it provides a solid grasp of measurement fundamentals and practices a wide variety of aerosol applications. This new edition is updated to address new and developing applications of aerosol measurement, including applications in environmental health, atmospheric science, climate change, air pollution, public health, nanotechnology, particle and powder technology, pharmaceutical research and development, clean room technology (integrated circuit manufacture), and nuclear waste management.

Optimization of Aerosol Drug Delivery
Author : Leon Gradon,J.C. Marijnissen
Publisher : Springer Science & Business Media
Release Date : 2003-11-30
ISBN 10 : 9781402016516
Pages : 315 pages

Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.

Murray and Nadel's Textbook of Respiratory Medicine E-Book
Author : Robert J. Mason,V.Courtney Broaddus,Thomas R Martin,Talmadge E King,Dean Schraufnagel,John F. Murray,Jay A. Nadel
Publisher : Elsevier Health Sciences
Release Date : 2010-06-09
ISBN 10 : 1437735533
Pages : 2440 pages

Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.

Drug Delivery to the Lung
Author : Hans Bisgaard,Chris O'Callaghan,Gerald C. Smaldone
Publisher : CRC Press
Release Date : 2001-10-02
ISBN 10 : 9780824741976
Pages : 536 pages

This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract! Featuring over 1300 references, drawings, tables, photographs,

Drug Carrier Systems
Author : Frits H. Roerdink,Frederik Herman D. Roerdink,A. M. Kroon
Publisher : John Wiley & Sons
Release Date : 1989
ISBN 10 :
Pages : 330 pages

Presents the main developments of the past 20 years, relating advances in systems that release the active drug in a sustained and controlled way, and new drugs that address more specifically the tissues and cells with which they are designed to interact. Considers the problems of biodistribution and biodegradation, with in-depth discussion of the selectivity and toxicity of the drugs administered by the various carrier systems. Topics covered range from antibodies, polymers, liposomes, erythrocytes and erythrocyte ghosts, to implantable infusion pumps. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR

Respiratory Drug Delivery (1989)
Author : Peter R. Byron
Publisher : CRC Press
Release Date : 2018-04-20
ISBN 10 : 1351358014
Pages : 276 pages

The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider toxicology from the point of view of drugs and pharmaceutical excipients used in aerosols.

Pulmonary Drug Delivery
Author : Ali Nokhodchi,Gary P. Martin
Publisher : John Wiley & Sons
Release Date : 2015-08-03
ISBN 10 : 1118799542
Pages : 384 pages

Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.