postmortem toxicology

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Postmortem Toxicology of Abused Drugs
Author : Steven B. Karch, MD, FFFLM
Publisher : CRC Press
Release Date : 2007-10-09
ISBN 10 : 9781420054545
Pages : 216 pages

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Postmortem Toxicology of Abused Drugs considers the role of toxicology in the investigation of homicide, suicide, accident, natural death, and overdose. It gives practical insights and case reviews on conducting toxicology tests and completing toxicology reports. It explains chain of custody; specimen collection and security; sampling of blood, urine, bile, and vitreous humor; and the selection of post-mortem specimens. Analyzing various testing procedures, the book covers simple chemical tests, microdiffusion tests, chromatography, spectroscopy, and more. It also discusses methods and strategies for analysis; and covers quality assurance protocols and controls. To help avoid common pitfalls, the text demonstrates the proper interpretation of postmortem drug levels based on knowledge of pharmacokinetics, metabolism, and pharmacogenetics; post-mortem redistribution and diffusion; and other considerations such as synergistic toxicity, and drug instability. Heavily referenced and containing several tables, figures, and useful appendices, this book is a handy reference for forensic scientists and medical examiners involved with death investigation.

Postmortem Toxicology
Author : Timothy P. Rohrig
Publisher : Academic Press
Release Date : 2019-02-22
ISBN 10 : 0128151641
Pages : 266 pages

Postmortem Toxicology addresses the various aspects of the practice of forensic postmortem toxicology from a viewpoint of elements which must be taken into consideration for proper interpretation of the toxicological result, not in a vacuum but in a more holistic and global sense. The volume examines pre-analytical factors, storage containers/conditions, prior medical interventions and therapy, along with information from the scene investigation and anatomical findings. This reference also provides explanation of the complicating conditions for the interpretation of the toxicological results due to postmortem decomposition, embalming artifacts and the postmortem redistribution of drugs. Tolerance is also discussed as an aid to interpreting results from a habitual/chronic user of medications and/or drugs of abuse. The book is geared towards the current practitioner; however, it is written to be used as a valuable reference for a graduate or post-graduate level courses in forensic toxicology or forensic pathology. Presents a holistic approach to the interpretation of toxicology results Covers pre-analytical factors, storage containers/conditions, prior medical interventions, therapy, and much more Written for the current practitioner, but an excellent resource for graduate level students training in the field of forensic toxicology

Fundamentals of Analytical Toxicology
Author : Robert J. Flanagan
Publisher : John Wiley & Sons
Release Date : 2007
ISBN 10 : 0470319348
Pages : 505 pages

The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay ? are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: ?This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.? Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists ?Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background ?Boxes?. The many and up to date literature references in each chapter demonstrate the authors? thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.? GTFCh Bulletin ?Toxichem + Krimtech?, May 2008 (translated, original review in German) ?Many toxicologists will add this important reference to their libraries because it competently fills a need ...? International Journal of Toxicology ?The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.? International Journal of Environmental Analytical Chemistry

Forensic Toxicology
Author : Max M. Houck
Publisher : Academic Press
Release Date : 2018-01-02
ISBN 10 : 0128008180
Pages : 418 pages

Forensic Toxicology, the latest release in the Advanced Forensic Science Series that grew out of recommendations from the 2009 NAS Report, Strengthening Forensic Science: A Path Forward will serve as a graduate level text for those studying and teaching forensic toxicology. It is also an excellent reference for the forensic practitioner’s library or for use in their casework. Coverage includes a wide variety of methods used, along with pharmacology and drugs and professional issues they may encounter. Edited by a world-renowned, leading forensic expert, this updated edition is a long overdue solution for the forensic science community. Provides basic principles of forensic science and an overview of forensic toxicology Contains information on a wide variety of methods Covers pharmacology and drugs, matrices and interpretation Includes a section on professional issues, such as crime scene to court, lab reports, health and safety, post-mortem and drug facilitated crimes Incorporates effective pedagogy, key terms, review questions, discussion questions and additional reading suggestions

Clarke's Analytical Forensic Toxicology
Author : Gail Cooper,Adam Negrusz
Publisher : Pharmaceutical Press
Release Date : 2013-05-28
ISBN 10 : 0857110543
Pages : 656 pages

This second edition of Clarke's Analytical Forensic Toxicology offers a fresh perspective on the drugs and poisons that you are most likely to encounter in forensic toxicology, with a focus on collection, extraction and analysis. With additional features incorporated from the fourth edition of Clarke's Analysis of Drugs and Poisons this text is fully updated to reflect the advances in analytical and forensic toxicology. New and extended chapters include: sampling, storage and stability; in-utero exposure to drugs of abuse; drug-facilitated sexual assault; and extraction. Providing unrivalled comprehensive coverage of analytical forensic toxicology, this book is a crucial resource for students of forensic science, toxicology, clinical pharmacology and analytical chemistry. It is an invaluable tool for teachers in these subject areas and a key resource for those working in forensic science laboratories.

Distribution of Methadone and EDDP in Postmortem Toxicology Cases
Author : Jessica Amanda Jennings
Publisher : N.A
Release Date : 2005
ISBN 10 :
Pages : 176 pages

Toxicology Testing, An Issue of Clinics in Laboratory Medicine - E-Book
Author : Michael G. Bissell
Publisher : Elsevier Health Sciences
Release Date : 2012-09-24
ISBN 10 : 1455747874
Pages : 240 pages

This issue of Clinics in Laboratory Medicine, titled Toxicology Testing, includes the following topics; Progress in Clinical Toxicology Testing, The Prescription Drug Abuse Epidemic, Substance Abuse Among Healthcare Professionals, Pain Management Drug Testing, Ethanol Biomarkers, Newly-emerging Drugs of Abuse, Synthetic Cannabinoids, Synthetic Cathenones, Immunoassay Methodology in Drugs-of-abuse Testing, Toxicology Testing in Alternative Specimen Matrices, Principles and Procedures in Postmortem Toxicology, and Pharmacogenetics and the Future of Toxicology Testing. Advances in toxicology testing are paving the way for major improvements in the way scientists evaluate health risks posed by toxic chemicals. Toxicity tests help scientists better understand how the human body carries out normal functions that are key to maintaining health. Therefore, this topic is important to the field of Laboratory Medicine.

Medical Toxicology
Author : Richard C. Dart
Publisher : Lippincott Williams & Wilkins
Release Date : 2004
ISBN 10 : 9780781728454
Pages : 1914 pages

This thoroughly revised and updated Third Edition of the classic Medical Toxicology is the definitive reference on the management of poisoned patients. More than 300 well-organized chapters written by eminent authorities guide clinicians through the diagnosis and treatment of every poisoning or drug overdose. Chapter outlines, headings, and a detailed index enable readers to quickly locate exactly the information they need. This edition includes new chapters on biological and chemical weapons and on diagnosis of patients with apparent symptoms of poisoning when the cause is unknown. The book includes comparative commentary on toxicology practice in the United States, Europe, Australia, and Asia. Compatibility: BlackBerry® OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile™ Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Analytical and Practical Aspects of Drug Testing in Hair
Author : Pascal Kintz
Publisher : CRC Press
Release Date : 2006-08-30
ISBN 10 : 9781420006193
Pages : 382 pages

Many advances have been made since the publication of Drug Testing in Hair. The mid-1990s witnessed the progress in cannabis detection while the late 1990s focused on benzodiazepines detection and the applications in doping control. In more recent years, toxicologists centered on the detection in hair of a single exposure and the related applicatio

The Second Seven Years of the FAA's Postmortem Forensic Toxicology Proficiency-testing Program
Author : Arvind K. Chaturvedi
Publisher : N.A
Release Date : 2008
ISBN 10 :
Pages : 11 pages

"For aircraft accident investigations, samples from pilot fatalities are analyzed at the Federal Aviation Administration's (FAA's) Civil Aerospace Medical Institute (CAMI) for the presence of combustion gases, alcohols/volatiles, and drugs. Throughout this forensic toxicological process, a high degree of quality control/quality assurance (QC/QA) is maintained, and quality improvement is continuously pursued. Under this philosophy, CAMI started a quarterly forensic toxicology proficiency-testing (PT) program in July 1991 for the analysis of postmortem specimens. In continuation of the first 7 years of the CAMI PT findings reported earlier, PT findings of the next 7 years (July 1998-April 2005) are summarized herein."--P. i.

Forensic Toxicology
Author : Kalipatnapu N. Rao
Publisher : CRC Press
Release Date : 2012-02-23
ISBN 10 : 1466558962
Pages : 289 pages

Modern technology using state-of-the-art equipment can now identify almost any toxin relevant to a legal issue. Techniques include gas chromatography, mass spectrometry, high-pressure liquid chromatography, and the combination of these methods. Forensic Toxicology: Medico-legal Case Studies demonstrates how the science of forensic toxicology acts a

Handbook of Forensic Medicine
Author : Burkhard Madea
Publisher : John Wiley & Sons
Release Date : 2014-03-17
ISBN 10 : 1118570626
Pages : 1312 pages

Forensic Medicine encompasses all areas in which medicine and law interact. This book covers diverse aspects of forensic medicine including forensic pathology, traumatology and violent death, sudden and unexpected death, clinical forensic medicine, toxicology, traffic medicine, identification, haemogenetics and medical law. A knowledge of all these subdisciplines is necessary in order to solve routine as well as more unusual cases. Taking a comprehensive approach the book m.oves beyond a focus on forensic pathology to include clinical forensic medicine and forensic toxicology. All aspects of forensic medicine are covered to meet the specialist needs of daily casework. Aspects of routine analysis and quality control are addressed in each chapter. The book provides coverage of the latest developments in forensic molecular biology, forensic toxicology, molecular pathology and immunohistochemistry. A must-have reference for every specialist in the field this book is set to become the bench-mark for the international forensic medical community.

Textbook Of Forensic Medicine And Toxicology: Principles And Practice
Author : Vij
Publisher : Elsevier India
Release Date : 2008
ISBN 10 : 9788131211298
Pages : 756 pages

The book is a comprehensive and authoritative exposition of Forensic Medicine and Toxicology. It provides precise and useful information on relevant legal provisions and forensic anatomy, and promotes interdisciplinary understanding of issues where law an medicine converge. The text is oriented towards the practical problems ncountered during day-to-day medicollegal work. About the Author : - Krishnan Vij, MD, L.L.B. is Professor and Head, Department of Forensic Medicine and Toxicology, Government Medical College & Hospital, Chandigarh, India.

Drug Abuse Handbook
Author : Steven B. Karch, MD, FFFLM
Publisher : CRC Press
Release Date : 2019-07-17
ISBN 10 : 9781420048292
Pages : 1152 pages

This is the handbook that professionals who deal with problems related to drugs and drug abuse have been waiting for. The impressive list of more than 80 contributors, each experts and leaders in their field, testifies to the importance of this outstanding new handbook. The volume contains detailed discussions of drug-related issues in criminalistics, pathology, and toxicology. Impairment testing and the pharmacokinetics of abused drugs are examined in detail, as is the field of workplace drug testing, the use of alternate testing matrices, drugs in sports, addiction medicine, and drug-related medical emergencies. The handbook focuses on the most urgent drug abuse-related problems of today An entire section is devoted to alcohol abuse, including a scientific appraisal of the most common drunk driving defenses, complete with sample calculations. Problems of postmortem toxicology are thoroughly detailed and an appendix lists key references for the most widely used analytic methods. An in-depth analysis of legal questions, including fetal rights and workplace testing Examination of the principles of addiction medicine and how doctors handle substance abuse problems A section addressing drug use by athletes, including a summary of current Olympic Committee Regulations regarding substance use and the latest information on detecting abuse of Human Growth Hormone and Erythropoietin Whether you are approaching the issue of drug abuse from a medical, psychological, toxicological, or legal perspective, the Drug Abuse Handbook is the most authoritative and complete resource available.

Clinical Veterinary Toxicology - E-Book
Author : Konnie Plumlee
Publisher : Elsevier Health Sciences
Release Date : 2003-12-10
ISBN 10 : 0323058345
Pages : 504 pages

This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated. Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons. Most comprehensive toxicology book available Written in a user-friendly style that makes it easy to master the content Covers poisonings in both large and small domestic animals The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information

The Second Seven Years of the FAA's Postmortem Forensic Toxicology Proficiency-Testing Program
Author : N.A
Publisher : N.A
Release Date : 2008
ISBN 10 :
Pages : 18 pages

For aircraft accident investigations, samples from pilot fatalities are analyzed at the Federal Aviation Administration's (FAA's) Civil Aerospace Medical Institute (CAMI) for the presence of combustion gases, alcohols/volatiles, and drugs. Throughout this forensic toxicological process, a high degree of quality control/quality assurance (QC/QA) is maintained, and quality improvement is continuously pursued. Under this philosophy, CAMI started a quarterly forensic toxicology proficiency-testing (PT) program in July 1991 for the analysis of postmortem specimens. In continuation of the first 7 years of the CAMI PT findings reported earlier, PT findings of the next 7 years (July 1998-April 2005) are summarized herein. During this period, 28 PT challenge survey samples (12 urine, 9 blood, and 7 tissue homogenate) with/without alcohols/volatiles, drugs, drug metabolites, and/or putrefactive amine(s) were submitted to an average of 31 participating laboratories, of which an average of 25 participants returned their result sheets-that is, 53-96% (mean = 82%). The number of respondents was dependent upon the complexity of the sample matrix, the number and types of analytes in the sample, and the associated analytical chemistry/toxicology. For example, ethanol/methanol/volatiles in urine were correctly quantitated by a higher number of participants than those for amphetamine/methamphetamine and cannabinoid levels in blood and tissues. Methods employed ranged from immunoassays to gas chromatography-mass spectrometry/high-performance liquid chromatography. Analytes in survey samples were correctly identified and quantitated by a large number of participants, but some false positives of concern were reported, as some of them were abused drugs. Some of the false positives would have been avoided by not reporting those drugs solely based upon presumptive analyses.

Forensic Science and Law
Author : Cyril H. Wecht,John T. Rago
Publisher : CRC Press
Release Date : 2005-12-22
ISBN 10 : 1420058118
Pages : 728 pages

Forensic science has undergone dramatic progress in recent years, including in the areas of DNA collection and analysis and the reconstruction of crime scenes. However, too few professionals are equipped with the knowledge necessary to fully apply the potential of science in civil, criminal, and family legal matters. Featuring contributions from renowned experts in the forensic, scientific, and legal professions, Forensic Science and Law: Investigative Applications in Criminal, Civil, and Family Justice communicates the wide range of methods and approaches used for achieving justice in these circumstances. A solid grounding in the underlying principles of our legal system provides a context for understanding how these methods are applied. The book brings together the words and thoughts of diverse professionals whose common goal is to uncover the truth. About the editors... Cyril H. Wecht, M.D., J.D., is actively involved as a medical-legal and forensic science consultant, author, and lecturer. Currently coroner of Allegheny County (Pittsburgh), Pennsylvania, he is certified by the American Board of Pathology in anatomic, clinical, and forensic pathology and is a Fellow of the College of American Pathologists and the American Society of Clinical Pathologists. Dr. Wecht is a Clinical Professor at the University of Pittsburgh Schools of Medicine, Dental Medicine, and Graduate School of Public Health, an Adjunct Professor at Duquesne University Schools of Law, Pharmacy and Health Services, and a Distinguished Professor at Carlow University. He is a past president of both the American College of Legal Medicine and the American Academy of Forensic Sciences. Dr. Wecht is the author of more than 500 professional publications and has appeared as a guest on numerous national television and radio talk shows. John T. Rago, J.D., is Assistant Professor of Law at Duquesne University School of Law and the Director of both The Cyril H. Wecht Institute of Forensic Science and Law and the Law School’s Post-conviction DNA Project. He teaches criminal law and procedure to law students and graduate courses on wrongful convictions, foundations in American law and constitutional criminal procedure to students in the university’s Bayer School of Natural and Environmental Sciences. Professor Rago also serves as an appointed member to the Innocence Project’s Policy Group of the Cardozo School of Law in New York. He is admitted to practice before the Pennsylvania Supreme Court, the United States Supreme Court, the U.S. Court of Appeals for the Third Circuit and the U.S. District Court for the Western District of Pennsylvania.

Forensic Issues in Alcohol Testing
Author : Steven B. Karch, MD, FFFLM
Publisher : CRC Press
Release Date : 2016-04-19
ISBN 10 : 9781420054460
Pages : 154 pages

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Forensic Issues in Alcohol Testing offers concise and focused information specific to the interests of forensic scientists and clinical and forensic toxicologists. It analyzes the acute effects of alcohol intoxication and the methods by which investigators can measure alcohol concentration in blood, urine, and breath. It considers extenuating circumstances affecting acute impairment by detailing the disposition and fate of alcohol in the body as well as the factors influencing absorption, distribution, and elimination. Specific chapters address difficulties in measuring and interpreting post-mortem alcohol concentrations due to poor quality of specimen, sampling site differences, and post-mortem diffusion or synthesis. Recent advances in biochemical testing make it possible to quantitate chronic alcohol ingestion, and the book analyzes the efficacy of these tests as evaluators of dependence or potential for dependence.

Forensic Nursing Science - E-Book
Author : Virginia A. Lynch,Janet Barber Duval
Publisher : Elsevier Health Sciences
Release Date : 2010-07-23
ISBN 10 : 0323066380
Pages : 704 pages

Written and edited by the most respected authorities in forensic nursing and forensic sciences, this new edition provides the tools and concepts you need to collect evidence that is admissible in court, determine the significance of that evidence, and provide accurate, reliable testimony while administering high-quality patient care. Now in full color throughout, it remains the most comprehensive, highly illustrated text of its kind. Provides a comprehensive, updated guide to forensic nursing science, paying special attention to the International Association of Forensic Nurses’s (IAFN) goals for forensic nursing. Retains a focus on assessment skills and the collection and preservation of evidence, following the established guidelines of the forensic sciences. Prepares you to provide testimony as a fact witness or a forensic nursing expert. Includes an illustrated case study in almost every chapter, helping you relate the information to clinical practice. Highlights important recommendations for interventions in Best Practice boxes, including the evidence base for each. Summarizes important points in Key Point boxes, so you can quickly review the most important concepts in each chapter. Explores the evolving role of forensic nurses in today’s health care facilities and the community. Edited by Virginia Lynch, founding member and first President of the International Association of Forensic Nurses and Janet Barber Duval, both well-respected pioneers and educators in the field. Contains 300 full-color illustrations integrated throughout the text, so you can view evidence quickly and easily, as it is likely to appear in practice. Presents information on courtroom testimony and depositions in one reorganized, streamlined chapter, giving you a full, organized treatment of this extremely important topic. Includes twelve new chapters: Digital Evidence, Medical Evidence Recovery at the Death Scene, Asphyxia, Electrical and Thermal Injury, Intrafamilial Homicide and Unexplained Childhood Death, Human Trafficking, Credential Development for Forensic Nurses, Gangs and Hate Crimes, Ethics Issues in Forensic Nursing, Forensic Physics and Fracture Analysis, Sexual Deviant Behaviors and Crime and Forensic Epidemiology. Contains heavily revised information on Prehospital Evidence, Forensic Investigation in the Hospital, and Human Abuse and Deaths in Custody. Features critical thinking questions with every case study, so you can thoroughly consider the implications of each clinical scenario. Evolve site will include appendices and additional documentation materials.

Goldfrank's Toxicologic Emergencies
Author : Lewis R. Goldfrank,Robert S. Hoffman,Mary Ann Howland,Neal A. Lewin
Publisher : McGraw Hill Professional
Release Date : 2006
ISBN 10 : 9780071479141
Pages : 1981 pages

Authoritative reference in clinical toxicology delivers a wealth of information on virtually all aspects of medical toxicology from pharmacology and clinical presentation to treatment guidelines and case studies.