physicochemical modification of curcumin and the impact on biological activities

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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Release Date : 2007-08-06
ISBN 10 : 0387464018
Pages : 490 pages

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Author : Seid Mahdi Jafari,D. Julian McClements
Publisher : Academic Press
Release Date : 2018-02-24
ISBN 10 : 0128118393
Pages : 664 pages

Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. Summarizes general aspects of food nanoemulsions and their formulation Provides detailed information on the production, application, and characterization of food nanoemulsion Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations Explains preparation of nanoemulsions by both low- and high-energy methods

Curcumin in Health and Disease
Author : Beatrice E. Bachmeier
Publisher : MDPI
Release Date : 2019-10-11
ISBN 10 : 3039214497
Pages : 274 pages

The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

Epigenetics and Epigenomics
Author : Christopher J. Payne
Publisher : BoD – Books on Demand
Release Date : 2014-04-29
ISBN 10 : 9535113631
Pages : 220 pages

The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current understanding of the potential etiologies of Autism Spectrum Disorders. Additional chapters are devoted to DNA methylation, genomic imprinting and human reproduction. A discussion of the role of the epigenome in cancer prevention and polyphenols is also included. Authors provide research findings from both human data and animal model studies. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of epigenetics and epigenomics.

Micronutrients and Health
Author : Kalanithi Nesaretnam,Lester Packer
Publisher : The American Oil Chemists Society
Release Date : 2001
ISBN 10 : 9781893997196
Pages : 404 pages

Author : Jun Sasaki,Masaki Kichida
Publisher : Nova Biomedical
Release Date : 2012
ISBN 10 : 9781619424814
Pages : 266 pages

Curcumin is a natural product found in the rhizome of Curcuma longa. Ongoing research and clinical trials prove this natural phenolic compound to possess diverse pharmacological potency and is effective as an antioxidant, anti-inflammatory, antimicrobial/antiviral property and is also being considered as a cancer chemo-preventive agent. Topics discussed in this book include the implications of curcumin treatment of central nervous system disease; phosphorylase kinase inhibition in skin disease; PEGylated curcumin; the potential role of curcumin as a chemotherapeutic drug and the pharmaceutical implications of curcumin in the development of drugs for cystic fibrosis pharmacotherapy.

Author : Khalid Mahmood Zia,Farukh Jabeen,Muhammad Naveed Anjum,Saiqa Ikram
Publisher : Elsevier
Release Date : 2020-06-21
ISBN 10 : 0128168900
Pages : 588 pages

Bionanocomposites: Green Synthesis and Applications provides an in-depth study on the synthesis of a variety of bionanocomposites from different types of raw materials. In addition, the book offers an overview on the synthesis and applications of environmentally friendly bionanocomposites, with an emphasis on bionanocomposites of natural products. Final sections focus on various characterization techniques, their production, and the future prospects of sustainable bionanocomposites. Outlines the major characterization methods and processing techniques for bionanocomposites Explores how bionanocomopsites are being used to design new projects in medicine and environmental engineering Discusses how the properties of a variety of bionanocomposite classes make them suitable for particular industrial applications

Author : Venketeshwer Rao,Leticia Rao
Publisher : BoD – Books on Demand
Release Date : 2015-09-30
ISBN 10 : 9535121707
Pages : 350 pages

Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.

Biological Activities and Application of Marine Polysaccharides
Author : Emad Shalaby
Publisher : BoD – Books on Demand
Release Date : 2017-01-11
ISBN 10 : 9535128590
Pages : 328 pages

Marine organisms have been under research for the last decades as a source for different active compounds with various biological activities and application in agriculture, pharmacy, medicine, environment, and industries. Marine polysaccharides from these active compounds are used as antibacterial, antiviral, antioxidant, anti-inflammation, bioremediations, etc. During the last three decades, several important factors that control the production of phytoplankton polysaccharides have been identified such as chemical concentrations, temperature, light, etc. The current book includes 14 chapters contributed by experts around the world; the chapters are categorized into three sections: Marine Polysaccharides and Agriculture, Marine Polysaccharides and Biological Activities, and Marine Polysaccharides and Industries.

Author : Janice Aldrich-Wright
Publisher : Springer
Release Date : 2011-04-06
ISBN 10 : 9783211990797
Pages : 427 pages

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Secondary Metabolites
Author : Ramasamy Vijayakumar,Suresh S.S. Raja
Publisher : BoD – Books on Demand
Release Date : 2018-09-05
ISBN 10 : 1789236428
Pages : 148 pages

This book consists of an introductory overview of secondary metabolites, which are classified into four main sections: microbial secondary metabolites, plant secondary metabolites, secondary metabolites through tissue culture technique, and regulation of secondary metabolite production. This book provides a comprehensive account on the secondary metabolites of microorganisms, plants, and the production of secondary metabolites through biotechnological approach like the plant tissue culture method. The regulatory mechanisms of secondary metabolite production in plants and the pharmaceutical and other applications of various secondary metabolites are also highlighted. This book is considered as necessary reading for microbiologists, biotechnologists, biochemists, pharmacologists, and botanists who are doing research in secondary metabolites. It should also be useful to MSc students, MPhil and PhD scholars, scientists, and faculty members of various science disciplines.

Author : P. N. Ravindran,K. Nirmal Babu,Kandaswamy Sivaraman
Publisher : CRC Press
Release Date : 2007-03-01
ISBN 10 : 9781420006322
Pages : 504 pages

For the last 6000 years turmeric has been used in Ayurvedic medicine to alleviate pain, balance digestion, purify body and mind, clear skin diseases, expel phlegm, and invigorate the blood. Nowadays, this plant has acquired great importance with its anti-aging, anti-cancer, anti-Altzheimer, antioxidant, and a variety of other medicinal properties. The need of the hour is to verify and validate the traditional uses by subjecting them to proper experimental studies. To do this effectively there needs to be a single comprehensive source of the knowledge to date. Turmeric: the genus Curcuma is the first comprehensive monographic treatment on turmeric. It covers all aspects of turmeric including botany, genetic resources, crop improvement, processing, biotechnology, pharmacology, medicinal and traditional uses, and its use as a spice and flavoring. Bringing together the premier experts in the field from India, Japan, UK, and USA, this book offers the most thorough examination of the cultivation, market trends, processing, and products as well as pharmacokinetic and medicinal properties of this highly regarded spice. While Ayurveda has known for millennia that turmeric cleanses the body, modern science has now discovered that it produces glutathione-s-transferase that detoxifies the body and therefore strengthens the liver, heart, and immune system. By comparing traditional uses with modern scientific discoveries, the text provides a complete view of the medicinal value and health benefits of turmeric. Heavily referenced with an exhaustive bibliography at the end of each chapter, the book collects and collates the currently available data on turmeric. Covering everything from cultivation to medicine, Turmeric: the Genus Curcuma serves as an invaluable reference for those involved with agriculture, marketing, processing or product development, and may function as a catalyst for future research into the health benefits and applications of turmeric.