|Author||: Maie A. St. John,No hee Park|
|Publisher||: Academic Press|
|Release Date||: 2020-06-29|
|ISBN 10||: 0128209291|
|Pages||: 266 pages|
Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region
|Author||: Joel E. Tepper|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2019-12-06|
|ISBN 10||: 0323672477|
|Pages||: 1648 pages|
A comprehensive, multidisciplinary resource for the entire radiation oncology team, Gunderson & Tepper’s Clinical Radiation Oncology, 5th Edition, thoroughly covers all aspects of this complex and dynamic field. Concise, templated chapters cover the basic biology of oncologic disease processes as well as updated treatment algorithms, the latest clinical guidelines, and state-of-the-art techniques and modalities. More than 1,000 images—detailed anatomy drawings, radiographic images, and more—provide outstanding visual support for every area of the text. Divides content into three distinct sections for quick access to information: Scientific Foundations, Techniques and Modalities, and Disease Sites. Disease Site chapters include overviews summarizing the most important issues and concluding discussions on controversies and problems. Features new and expanded content on molecular and cellular biology and its relevance in individualized treatment approaches, stereotactic radiation therapy, radiosurgery, proton therapy, biologic therapy, precision radiation therapy, targeted radiation, dosing guidelines for better quality of life and improved patient outcomes, and more. Includes new chapters on Radiation Physics: Particle Therapy, Interventional Radiology, Radiation Therapy in the Elderly, Palliative Care, Quality and Safety, and Immunotherapy with Radiotherapy. Provides guidance on single-modality and combined-modality approaches, as well as outcome data including disease control, survival, and treatment tolerance. Includes access to videos on Intraoperative Irradiation, Prostate Brachytherapy, Penile Brachytherapy, and Ocular Melanoma.
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Using a proven, practical, algorithmic approach, Surgical Decision Making summarizes evidence-based guidelines and practice protocols in an easy-to-follow format. Designed to sharpen the decision-making skills of both trainees and practicing surgeons, the 6th Edition directs your focus to the critical decision points in a wide range of clinical scenarios, helping you determine optimal evaluation and management to secure the best possible patient outcomes. Algorithms are accompanied by annotations that explain all critical factors affecting decisions in a concise, readable manner. Reflects the scope of practice of today’s general surgeon, with fresh, expert perspectives from new editor Dr. Richard Schulick and numerous new contributors. Contains 58 new chapters and thoroughly revised content throughout. Includes new coverage of Preoperative Evaluation of the Geriatric Patient, Pancreatic Cystic Neoplasm, Familial Breast Cancer, Resuscitative Endovascular Balloon Occlusion of the Aorta, Blunt Cerebrovascular Injury, and much more. Uses an easy-to-follow, consistent format, with an algorithm on one page and short descriptions explaining the various steps in the decision-making process on the opposite page. Includes explanatory notes that summarize presenting signs and symptoms, laboratory investigation, diagnostic modalities, surgical therapies, and adjuvant therapies for each condition. Encompasses both general surgery and surgical subspecialties―helping you directly manage a broad range of problems. Emphasizes information that frequently appears on board exams.
To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.
|Publisher||: Academic Press|
|Release Date||: 2018-11-21|
|ISBN 10||: 0128127384|
|Pages||: 292 pages|
Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment
|Publisher||: Academic Press|
|Release Date||: 2019-10-04|
|ISBN 10||: 0128178698|
|Pages||: 376 pages|
Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data
|Author||: Maxine Papadakis,Stephen J. McPhee,Michael W. Rabow|
|Publisher||: McGraw Hill Professional|
|Release Date||: 2014-09-05|
|ISBN 10||: 007182491X|
|Pages||: 1920 pages|
To deliver the best care to your patients, turn to the #1 annually updated guide in internal medicine and clinical practice. The 2015 Edition is packed with important NEW information! For more than 70 years, professors, students, and clinicians have trusted LANGE for high-quality, current, concise medical information in a convenient, affordable, portable format. Whether for coursework, clerkships, USMLE prep, specialty board review, or patient care, there's a LANGE book that guarantees success. NEW TO THIS EDITION: Latest 2014 American Heart Association/American College of Cardiology guidelines for anticoagulation in atrial fibrillation, and indications for interventions in valvular heart disease Update on the epidemic of opioid-based prescription drug abuse, misuse and overdose, and new section on opioids for chronic, noncancer pain Revised treatment options for Helicobacter pylori and chronic hepatitis C Latest hypertension information from 2013 UK National Institute of Health and Clinical Excellence and US Joint National Committee (JNC8) Reports Discussion of which patients benefit from statins, and indications for high vs. moderate intensity statins, based on 2014 AHA/ACC guidelines Scoring tools for assessing the severity of acute pancreatitis Revised psychiatric diagnoses in accordance with the Diagnostic Statistical Manual’s 5th edition No other text links practice and research like CURRENT Medical Diagnosis & Treatment! Written by clinicians renowned in their fields, this trusted annual text offers the most current insight into symptoms, signs, epidemiology, diagnosis, prevention, and treatment for more than 1,000 diseases and disorders. You'll find concise, evidence-based answers to questions about both hospital and ambulatory problems. The streamlined format of each section in this clinical companion is the fastest, easiest way to keep abreast of the latest diagnostic advances, prevention strategies, and cost-effective treatments. Here's why CMDT is essential to your clinical practice: Strong emphasis on the practical aspects of clinical diagnosis and patient management throughout the broad fields of internal medicine Full review of other relevant primary care topics, including obstetrics/gynecology, dermatology, neurology, urology, ophthalmology, orthopedics, geriatrics, women’s health, and palliative care Hundreds of medication treatment tables, with indexed trade names and updated prices Many helpful diagnostic and treatment algorithms Only text with an annual review of advances in HIV treatment Recent references with PMID numbers for easy online access Many full-color photographs and illustrations
The last ten years have seen the publication of a vast amount of data regarding cellular resistance to drugs in cancer cells. Recent studies have demonstrated that drug resistance assays appear to be predictive of clinical response and suggest that clinicians should now be considering the potential applications of these assays in the treatment of patients with hematological neoplasms. This collection of papers from the International Symposium on the Clinical Value of Drug Resistance Assays in Leukemia and Lymphoma, Amsterdam, 1992, provides a state-of-the-art discussion on drug resistance assays and their role in the design and individualization of treatment protocols.
Turn the latest research into improved patient outcomes with the #1 annual guide to internal medicine and clinical practice Written by clinicians renowned in their respective fields, CMDT offers the most current insight into symptoms, signs, epidemiology, diagnosis, and treatment for more than 1,000 diseases and disorders. You'll find concise, evidence-based answers to questions about hospital and ambulatory problems. This streamlined clinical companion is the fastest and easiest way to keep abreast of the latest diagnostic advances, prevention strategies, and cost-effective treatments. Features and content critical to clinical practice: Strong emphasis on the practical aspects of clinical diagnosis and patient management throughout the broad fields of internal medicine Full review of internal medicine and primary care topics, including gynecology and obstetrics, dermatology, neurology, ophthalmology, geriatrics, and palliative care The only text with an annual review of advances in HIV treatment Specific disease prevention information Hundreds of medication treatment tables, with indexed trade names and updated prices – plus helpful diagnostic and treatment algorithms Recent references with PMID numbers Many full-color photographs and illustrations NEW TO THIS EDITION: Update on the evaluation of chest pain New algorithms for the treatment of heart failure and NSTEMI New sections on pulmonary hypertension; treatment of pleural mesothelioma; diagnosis and treatment of subacute, postpartum, and silent thyroiditis and amiodarone- and iodine-induced thyrotoxicosis; and treatment of cryoglobulinemic vasculitis New tables on preferred initial antiretroviral regimen and fixed dose antiretroviral combinations for HIV infection, and on medications for management of diabetes Updated tables on cancer chemotherapeutic and supportive care agents Includes 5 online-only chapters at no additional cost Visit: www.AccessMedicine.com/CMDT
Looks at the essential conepts in the science of pharmacology and its application to clinical practice.
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
The use of copper, silver, gold and platinum in jewelry as a measure of wealth is well known. This book contains 19 chapters written by international authors on other uses and applications of noble and precious metals (copper, silver, gold, platinum, palladium, iridium, osmium, rhodium, ruthenium, and rhenium). The topics covered include surface-enhanced Raman scattering, quantum dots, synthesis and properties of nanostructures, and its applications in the diverse fields such as high-tech engineering, nanotechnology, catalysis, and biomedical applications. The basis for these applications is their high-free electron concentrations combined with high-temperature stability and corrosion resistance and methods developed for synthesizing nanostructures. Recent developments in all these areas with up-to-date references are emphasized.
|Author||: Loredana Marcu|
|Publisher||: BoD – Books on Demand|
|Release Date||: 2015-07-08|
|ISBN 10||: 9535121359|
|Pages||: 180 pages|
While the management of head and neck cancer has evolved over the last few decades, there are still several challenges and unanswered questions that need solutions. This book is a small compilation of some topical aspects regarding head and neck cancer treatment, including the etiology of HPV-positive oropharyngeal cancers and risk factors in the young population, the challenge of surgical margin definition and the perennial problem of systemic treatment due to distant metastases. Radiobiological aspects are also covered through the Rs of radiotherapy, with a couple of chapters being dedicated to radioresistance and tumour microenvironment. Contemporary Issues in Head and Neck Cancer Management comes as an addition to the existing literature that aims to tackle this radiobiologically challenging tumour.
It is difficult to imagine anyone who has not heard of cancer. This disease can affect families, friends or any one of us at any time in our lives. Every year nearly 3 million Europeans are diagnosed with cancer, leading to around 800,000 deaths per year. These deaths occur not only in aging populations, but also in children and adults who are in the most active period of their lives. This represents a tremendous problem that cannot be ignored by politicians or citizens. Fortunately, there is a constantly growing awareness that although cancer is a problem to be dealt with by clinicians, it should also be the concern of everyone. This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century".
|Author||: Sudip Mukherjee|
|Publisher||: Morgan & Claypool Publishers|
|Release Date||: 2019-10-29|
|ISBN 10||: 1643277863|
|Pages||: 49 pages|
In this book, cancer theranostics applications of magnetic iron oxide nanoparticles are overviewed in details. Moreover, their synthesis, characterization, multifunctionality, disease targeting, biodistribution, pharmacokinetics and toxicity have been briefly highlighted. Finally, we have mentioned the current examples of clinical trials of magnetic nanoparticles in cancer theranostics along with their future scopes and challenges.
This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors.
This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.