Nontuberculous Mycobacteria (NTM): Microbiological, Clinical and Geographical Distribution is a complete reference that stimulates a greater understanding of NTM infections. Sections cover microbiologic and molecular diagnostic tools, drug susceptibility tests, human genetic susceptibility, prevalence and incidence studies, clinical and radiological presentations, and clinical trials for antibiotic therapy. With the incidence rate of NTM infections increasing globally during the last decade, significant mortality and morbidity must be addressed. This important reference will provide research scientists, clinical microbiologists, hospital diagnostic technicians, and post graduate medical and science students with information on the epidemiology, prevalence, microbiology and clinical aspects of NTM. Highlights new findings in the epidemiological distribution and new diagnosis and treatment protocol of mycobacterial infections Debates new advances in the detection of NTM Demonstrates the distribution of NTM in the environment and its relationship with human infection using a geographical information system (GIS) Includes new radiological findings in non-tuberculous mycobacterial infections in the lung using CT and PET-Scan imaging
|Author||: David Schlossberg|
|Release Date||: 2006|
|Pages||: 523 pages|
The Definitive Text on Tuberculosis Infections for More Than Two Decades! This trusted resource provides infectious disease specialists with the most comprehensive coverage found anywhere of the varied manifestations of tuberculin diseases and the clinical options available to physicians for treating them. The new edition has been updated to reflect state-of-the-art changes in the direction and management of these diseases and contains new chapters on multi-drug resistance and the latest prophylactic strategies.
Incidence of pulmonary disease caused by nontuberculous mycobacteria (NTM), such as Mycobacterium abscessus and M. avium, is increasing at an alarming rate, surpassing tuberculosis (TB) in many countries. Treatment durations are extremely long. With low sputum conversion rates, the outcomes are often disappointing. Thus, NTM disease resembles extremely drug resistant TB. There is an urgent need for increased research on this dreadful disease. For this book we brought together experts from a wide range of disciplines addressing current status, gaps and needs, and new developments in several NTM-relevant research areas. We start with the discussion of NTM disease presentations and clinical research. This is followed by contributions on epidemiology, antibiotic resistance mechanisms, drug discovery and development, bacteriology and targets, and new diagnostic tools. We would like to thank the 130 authors for sharing their work and insights. We hope that this collection of articles will stimulate discussions and research activities on the challenging lung disease caused by the diverse group of pathogens called NTM.
|Author||: Elizabeth N. Stone|
|Release Date||: 1998|
|Pages||: 220 pages|
Actinobacteria have an extensive bioactive secondary metabolism and produce a huge amount of naturally derived antibiotics, as well as many anticancer, anthelmintic, and antifungal compounds. These bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects.
Since ocular infections are one of the most frequent occurrences in ophthalmology, the treatment for these infections must be fast, precise and effective. In order to address this goal, it is important to identify and characterize the culprit microorganisms involved in the pathogenesis of ocular infections. Clinical diagnosis of ocular infections can be confirmed by several techniques based on microbiological test of ocular samples. Some of these techniques include classic microbiological testing in which it is necessary to isolate microorganisms to characterize them by biochemical analysis which require significant resources and timing.
|Author||: David Schlossberg|
|Publisher||: American Society for Microbiology Press|
|Release Date||: 2011-05-24|
|ISBN 10||: 1555815138|
|Pages||: 654 pages|
The most popular reference among physicians for understanding and treating tuberculosis. • Presents the current science and tools available in the fight against tuberculosis, including drug-resistant forms, from international experts. • Features the latest preventive strategies, including vaccine development and explores the effect of tuberculosis on organ systems and value of surgery. • Examines present-day epidemiologic and public health issues, including airline-associated infection, tuberculosis in the developing world, and the role of the World Health Organization and departments of public health.
|Author||: Gwen A. Huitt|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2015-04-07|
|ISBN 10||: 0323356753|
|Pages||: 145 pages|
Drs. Huitt and Daley have assembled an expert panel of authors on the topic of Non-Tuberculosis Mycobacteria. Articles in this issue will include discussions in the following areas: The Pathogenesis of NTM, Epidemiology of NTM, Environmental Sources of NTM, Laboratory Diagnosis of NTM, Medications and Monitoring in NTM infections, Treatment of Rapidly Growing NTM, Treatment of Slow Growing NTM, NTM Infections in Immunocompromised Hosts, Extra Pulmonary NTM Infections, NTM Infections in Cystic Fibrosis, and Surgical Approach to NTM Infections.
Progress obtained by mycobacteriology in recent years is undeniable with regards to preventing, detecting, and treating cases of tuberculosis, millennial disease that is still present as public health issue worldwide. We present here high-impact research and interest topics related to the application of new methodologies, especially molecular methods for rapid diagnostic such as rapid DST, application of high performance liquid chromatography, molecular epidemiology and molecular diagnostic testing on post mortem. Currently, the constant search for vaccines that prevent the disease is promising through research of the immune response generated by the host towards the bacterium, and the effectiveness that may be achieved from developed vaccines. Another high-impact factor is the one generated by considering tuberculosis as a social disease with an infectious component reflected in research about tuberculosis and human rights. Finally, we present important issues of the pathogen interaction with different hosts. The constant knowledge generation that expands the frontiers of understanding is a key factor for finding solutions and successful activities for public health.
Environmental mycobacteria can be found in diverse environments around the world, some of which have the ability to infect animals, birds and humans and have evolved mechanisms by which they can invade and grow within host cells, the pathogenic environmental mycobacteria (PEM). Although the diseases caused by these organisms have been known for many years, it is only recently that the potential significance of PEM as a waterborne pathogen has been appreciated. This publication discusses current knowledge about the distribution of PEM in water and other parts of the environment, the routes of transmission that lead to human infection, the most significant disease symptoms that can follow infection, methods of analysis and detection, the control of PEM in drinking-water and the assessment and management of risks.