neurotherapeutics in the era of translational medicine

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Neurotherapeutics in the Era of Translational Medicine
Author : Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen
Publisher : Academic Press
Release Date : 2020-11-28
ISBN 10 : 0128172746
Pages : 518 pages
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For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis‎, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2007
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : N.A
Release Date : 2006
ISBN 10 :
Pages : 329 pages
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Neurological Emergencies
Author : Alejandro A. Rabinstein
Publisher : Springer Nature
Release Date : 2019-11-28
ISBN 10 : 3030280721
Pages : 390 pages
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This comprehensive and up-to-date book covers the common emergencies in neurology, neurosurgery, and psychiatry. Chapters examine a variety of neurological emergencies, and offer pragmatic approaches to treatment and management. High-quality tables, figures, and algorithms supplement expertly written text, and provide readers with clear, rapid answers in an easily accessible format. Additionally, the book includes discussions on less common conditions, and incorporates specific methods for treating specific populations, such as pregnant women and transplant patients. Neurological Emergencies: A Practical Approach is a go-to reference for all medical professions working in emergency treatment settings, and will increase their ability to better care for patients with acute neurological diseases.

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2007: Testimony of members of Congress and other interested individuals and organizations
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : N.A
Release Date : 2006
ISBN 10 :
Pages : 329 pages
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Mind Fixers: Psychiatry's Troubled Search for the Biology of Mental Illness
Author : Anne Harrington
Publisher : W. W. Norton & Company
Release Date : 2019-04-16
ISBN 10 : 1324001976
Pages : 384 pages
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Mind Fixers tells the history of psychiatry’s quest to understand the biological basis of mental illness and asks where we need to go from here. In Mind Fixers, Anne Harrington, author of The Cure Within, explores psychiatry’s repeatedly frustrated struggle to understand mental disorder in biomedical terms. She shows how the stalling of early twentieth century efforts in this direction allowed Freudians and social scientists to insist, with some justification, that they had better ways of analyzing and fixing minds. But when the Freudians overreached, they drove psychiatry into a state of crisis that a new “biological revolution” was meant to alleviate. Harrington shows how little that biological revolution had to do with breakthroughs in science, and why the field has fallen into a state of crisis in our own time. Mind Fixers makes clear that psychiatry’s waxing and waning biological enthusiasms have been shaped not just by developments in the clinic and lab, but also by a surprising range of social factors, including immigration, warfare, grassroots activism, and assumptions about race and gender. Government programs designed to empty the state mental hospitals, acrid rivalries between different factions in the field, industry profit mongering, consumerism, and an uncritical media have all contributed to the story as well. In focusing particularly on the search for the biological roots of schizophrenia, depression, and bipolar disorder, Harrington underscores the high human stakes for the millions of people who have sought medical answers for their mental suffering. This is not just a story about doctors and scientists, but about countless ordinary people and their loved ones. A clear-eyed, evenhanded, and yet passionate tour de force, Mind Fixers recounts the past and present struggle to make mental illness a biological problem in order to lay the groundwork for creating a better future, both for those who suffer and for those whose job it is to care for them.

Surgical Neuro-Oncology
Author : Russell R. Lonser,J. Bradley Elder
Publisher : Neurosurgery by Example
Release Date : 2018-11-09
ISBN 10 : 0190696699
Pages : 312 pages
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Part of the Neurosurgery by Example series, this volume on surgical neuro-oncology presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore a number of different types of nervous systems tumors, including glioblastoma, medulloblastoma, skull tumors, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Surgical Neuro-Oncology is appropriate for neurosurgeons who wish to learn more about this subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.

An Essay on the Shaking Palsy
Author : James Parkinson
Publisher : N.A
Release Date : 1817
ISBN 10 :
Pages : 66 pages
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Pain Management and the Opioid Epidemic
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Publisher : National Academies Press
Release Date : 2017-09-28
ISBN 10 : 0309459575
Pages : 482 pages
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Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Encyclopedia of Tissue Engineering and Regenerative Medicine
Author : N.A
Publisher : Academic Press
Release Date : 2019-06-03
ISBN 10 : 0128137002
Pages : 1418 pages
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Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Evidence-based Psychotherapy
Author : Carol D. Goodheart,Alan E. Kazdin,Robert J. Sternberg
Publisher : Amer Psychological Assn
Release Date : 2006
ISBN 10 :
Pages : 295 pages
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This book engages the voices of a broad range of clinical researchers, practitioners, educators, and public policy advocates in a comprehensive discussion of the spectrum of issues and arguments in the current debate about EBP.

Emerging Cognitive Neuroscience and Related Technologies
Author : National Research Council,Division on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Division on Engineering and Physical Sciences,Standing Committee for Technology Insight--Gauge, Evaluate, and Review,Committee on Military and Intelligence Methodology for Emergent Neurophysiological and Cognitive/Neural Science Research in the Next Two Decades
Publisher : National Academies Press
Release Date : 2008-12-06
ISBN 10 : 0309118948
Pages : 214 pages
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Emerging Cognitive Neuroscience and Related Technologies, from the National Research Council, identifies and explores several specific research areas that have implications for U.S. national security, and should therefore be monitored consistently by the intelligence community. These areas include: neurophysiological advances in detecting and measuring indicators of psychological states and intentions of individuals the development of drugs or technologies that can alter human physical or cognitive abilities advances in real-time brain imaging breakthroughs in high-performance computing and neuronal modeling that could allow researchers to develop systems which mimic functions of the human brain, particularly the ability to organize disparate forms of data. As these fields continue to grow, it will be imperative that the intelligence community be able to identify scientific advances relevant to national security when they occur. To do so will require adequate funding, intelligence analysts with advanced training in science and technology, and increased collaboration with the scientific community, particularly academia. A key tool for the intelligence community, this book will also be a useful resource for the health industry, the military, and others with a vested interest in technologies such as brain imaging and cognitive or physical enhancers.

Future Directions in Post-Traumatic Stress Disorder
Author : Marilyn P. Safir,Helene S. Wallach,Albert "Skip" Rizzo
Publisher : Springer
Release Date : 2014-11-26
ISBN 10 : 1489975225
Pages : 430 pages
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Ours is an era of increasing tension, both global and local. And not surprisingly, PTSD is recognized not only in combat veterans and active military personnel, but also disaster and assault survivors across the demographic spectrum. As current events from mass shootings to the debate over trigger warnings keep the issue in the public eye, the disorder remains a steady concern among researchers and practitioners. Future Directions in Post-Traumatic Stress Disorder presents findings and ideas with the potential to influence both our conceptualization of the condition and the techniques used to address it. A multidisciplinary panel of experts offers new analyses of risk and resilience factors, individual and group approaches to prevention, the evolving process of diagnosis, and effective treatment and delivery. Chapters on treatment allow readers to compare widely-used prolonged exposure and VR methods with innovative applications of cognitive processing therapy and interpersonal therapy. And an especially compelling contribution surveys empirically-based programs relating to what for many is the emblematic trauma of our time, the events of September 11, 2001. Included in the coverage: Predictors of vulnerability to PTSD: neurobiological and genetic risk factors. Early intervention: is prevention better than cure? The functional neuroanatomy of PTSD. The development of evidence-based treatment for PTSD. Enhancing exposure therapy using D-Cycloserine (DCS). PLUS: a case example as seen through five therapeutic perspectives. While millions experience trauma, relatively few develop chronic PTSD. Future Directions in Post-Traumatic Stress Disorder is a practical and proactive reference for the health and clinical psychologists, sociologists, psychiatrists, and primary care physicians dedicated to further decreasing those numbers.