neurophotonics and biomedical spectroscopy

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Neurophotonics and Biomedical Spectroscopy
Author : Robert R. Alfano,Lingyan Shi
Publisher : William Andrew
Release Date : 2018-11-22
ISBN 10 : 0323480683
Pages : 610 pages

Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, Alzheimer’s disease, tissue and cell response to therapeutic intervention, unintended injury and laser energy deposition. The book then highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/diseased nerve tissues and in the brain, providing a better understanding of the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures. Topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation, and more. Provides an overview of the spectroscopic properties of tissue and tissue-light interaction, describing techniques to exploit these properties in imaging Explores the potential and significance of molecule-specific imaging and its capacity to reveal vital new information on nanoscale structures Offers a concise overview of different spectroscopic methods and their potential benefits for solving diagnostic and therapeutic problems

Handbook of Neurophotonics
Author : Francesco S. Pavone,Shy Shoham
Publisher : CRC Press
Release Date : 2020-05-10
ISBN 10 : 1498718760
Pages : 448 pages

The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Neurophotonics and Brain Mapping
Author : Yu Chen,Babak Kateb
Publisher : CRC Press
Release Date : 2017-06-14
ISBN 10 : 1482236869
Pages : 563 pages

Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.

Fluorescence Lifetime Spectroscopy and Imaging
Author : Laura Marcu,Paul M. W. French,Daniel S. Elson
Publisher : CRC Press
Release Date : 2014-07-17
ISBN 10 : 1439861684
Pages : 570 pages

During the past two decades, there has been an increasing appreciation of the significant value that lifetime-based techniques can add to biomedical studies and applications of fluorescence. Bringing together perspectives of different research communities, Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Dia

Terahertz Biomedical Science and Technology
Author : Joo-Hiuk Son
Publisher : CRC Press
Release Date : 2014-06-13
ISBN 10 : 146657044X
Pages : 377 pages

A number of applications including scientific spectroscopy, security screening, and medical imaging have benefitted from the development and utilization of new and emerging terahertz (THz) generation and detection techniques. Exploring recent discoveries and the advancements of biological behaviors through THz spectroscopy and imaging and the development of THz medical techniques, Terahertz Biomedical Science and Technology contains contributions from scientists and researchers in the terahertz biomedical field and is exclusively dedicated to new and emerging terahertz biomedical research and applications. This text offers an assessment of terahertz technology, and provides a compilation of fundamental biological studies conducted using terahertz waves. It introduces THz electromagnetic waves as a new tool for convergent studies, includes laser-based generation techniques and solid-state devices, contains a number of detectors, and discusses high-field generation methods. The material covers recent advancements in terahertz imaging for medical applications—most specifically in cancer diagnosis—reviewing the current status of the THz imaging technique for diagnosing cancers, and exploring the potential medical applications of THz radiation. It also considers the development of future medical applications using terahertz technology. Summarizes the recent progress made in THz waveguides, which are absolutely essential in the development of THz endoscopes Describes the dynamic imaging of drug absorption in skin, exploiting the sensitivity of THz waves to pharmaceutical materials Explores the principle and applications of THz molecular imaging techniques using nanoparticle probes Scientists and engineers involved in biological research and medical applications using optical techniques, as well as graduate students and instructors in optics, physics, electrical engineering, biology, chemistry, and medicine can benefit from this text which highlights new and emerging biomedical studies utilizing novel THz wave techniques.

Handbook of Optical Biomedical Diagnostics
Author : Valeriĭ Viktorovich Tuchin
Publisher : N.A
Release Date : 2016
ISBN 10 : 9781628419122
Pages : 688 pages

This text begins by describing the basic principles and diagnostic applications of optical techniques based on detecting and processing the scattering, fluorescence, FT IR, and Raman spectroscopic signals from various tissues, with an emphasis on blood, epithelial tissues, and human skin. The second half of the volume discusses specific imaging technologies, such as Doppler, laser speckle, optical coherence tomography (OCT), and fluorescence and photoacoustic imaging.

Biomedical Optical Imaging
Author : James G. Fujimoto,Daniel Farkas
Publisher : Oxford University Press
Release Date : 2009-04-22
ISBN 10 : 9780199722297
Pages : 440 pages

Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.

Handbook of Biomedical Optics
Author : David A. Boas,Constantinos Pitris,Nimmi Ramanujam
Publisher : CRC Press
Release Date : 2016-04-19
ISBN 10 : 1420090372
Pages : 831 pages

Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental

Deep Imaging in Tissue and Biomedical Materials
Author : Lingyan Shi,Robert R. Alfano
Publisher : CRC Press
Release Date : 2017-03-16
ISBN 10 : 1351797387
Pages : 524 pages

The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.

Biomedical Optics
Author : Lihong V. Wang,Hsin-i Wu
Publisher : John Wiley & Sons
Release Date : 2012-09-26
ISBN 10 : 0470177004
Pages : 376 pages

This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected]

Tissue Optics
Author : Valery Tuchin
Publisher : N.A
Release Date : 2015
ISBN 10 : 9781628415162
Pages : 988 pages

This third edition of the biomedical optics classic Tissue Optics covers the continued intensive growth in tissue optics—in particular, the field of tissue diagnostics and imaging—that has occurred since 2007. As in the first two editions, Part I describes fundamentals and basic research, and Part II presents instrumentation and medical applications. However, for the reader’s convenience, this third edition has been reorganized into 14 chapters instead of 9. The chapters covering optical coherence tomography, digital holography and interferometry, controlling optical properties of tissues, nonlinear spectroscopy, and imaging have all been substantially updated. The book is intended for researchers, teachers, and graduate and undergraduate students specializing in the physics of living systems, biomedical optics and biophotonics, laser biophysics, and applications of lasers in biomedicine. It can also be used as a textbook for courses in medical physics, medical engineering, and medical biology.

Handbook of Biophotonics, Volume 3
Author : Jurgen Popp,Jürgen Popp,Valery V. Tuchin,Arthur Chiou,Stefan H. Heinemann
Publisher : John Wiley & Sons
Release Date : 2012-05-14
ISBN 10 : 352741049X
Pages : 304 pages

The new, fully colored standard in Biophotonics to serve as THE reference for the scientific basics and the latest applications in life science!

The Basics of Spectroscopy
Author : David Warren Ball
Publisher : SPIE Press
Release Date : 2001
ISBN 10 : 9780819441041
Pages : 122 pages

Spectroscopy--the study of matter using electromagnetic radiation--and its applications as a scientific tool are the focus of this tutorial. Topics covered include the interaction of light with matter, spectrometer fundamentals, quantum mechanics, selection rules, and experimental factors.

Oxygen Transport to Tissue XL
Author : Oliver Thews,Joseph C. LaManna,David K. Harrison
Publisher : Springer
Release Date : 2018-09-03
ISBN 10 : 3319912879
Pages : 452 pages

The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.

Intraoperative Ultrasound (IOUS) in Neurosurgery
Author : Francesco Prada,Luigi Solbiati,Alberto Martegani,Francesco DiMeco
Publisher : Springer
Release Date : 2016-03-08
ISBN 10 : 3319252682
Pages : 187 pages

This book is intended as a practical manual on the use of intraoperative ultrasound (IOUS) as a tool for imaging guidance during cranial and spinal neurosurgical procedures. Full account is taken of the emergence of novel clinical applications and recent technical advances, with extensive coverage of the impact of developments such as improved probe technology, fusion imaging and virtual navigation, 3D ultrasound imaging, contrast-enhanced ultrasound, and elastosonography. Basic principles of ultrasound are elucidated in order to assist in the optimal use of IOUS and clear guidance is provided on the interpretation of imaging findings in various pathologies. Informative comparisons are also made of the use of techniques such as fusion imaging and contrast-enhanced ultrasound in general radiology and neurosurgery. The aim of the authors is to enhance the general knowledge regarding intra-operative ultrasound brain imaging, standardizing its use and exploring new techniques, leading in some way toward compensating the lack of specific training in the application of ultrasound among the neurosurgical community. IOUS is a sensitive tool that can improve surgical precision and help to reduce morbidity.

Optical Design for Biomedical Imaging
Author : Rongguang Liang
Publisher : SPIE-International Society for Optical Engineering
Release Date : 2010-01-01
ISBN 10 : 9780819483690
Pages : 491 pages

Designing an efficient imaging system for biomedical optics requires a solid understanding of the special requirements of the optical systems for biomedical imaging and the optical components used in the systems. However, a lack of reference books on optical design (imaging and illumination) for biomedical imaging has led to some inefficient systems. This book fills the gap between biomedical optics and optical design by addressing the fundamentals of biomedical optics and optical engineering, and biomedical imaging systems. The first half provides a brief introduction to biomedical optics and then covers the fundamentals of optics, optical components, light sources, detectors, optical imaging system design, and illumination system design. This also includes important issues related to biomedical imaging, such as autofluorescence from optical materials. The second half of the text covers various biomedical imaging techniques and their optical systems, along with design examples.

Optical Neural Interfaces
Author : Massimo De Vittorio,Ferruccio Pisanello,John A. Assad
Publisher : Frontiers Media SA
Release Date : 2019-11-01
ISBN 10 : 2889630803
Pages : 329 pages

Optics in Our Time
Author : Mohammad D. Al-Amri,Mohamed El-Gomati,M. Suhail Zubairy
Publisher : Springer
Release Date : 2016-12-12
ISBN 10 : 3319319035
Pages : 504 pages

Light and light based technologies have played an important role in transforming our lives via scientific contributions spanned over thousands of years. In this book we present a vast collection of articles on various aspects of light and its applications in the contemporary world at a popular or semi-popular level. These articles are written by the world authorities in their respective fields. This is therefore a rare volume where the world experts have come together to present the developments in this most important field of science in an almost pedagogical manner. This volume covers five aspects related to light. The first presents two articles, one on the history of the nature of light, and the other on the scientific achievements of Ibn-Haitham (Alhazen), who is broadly considered the father of modern optics. These are then followed by an article on ultrafast phenomena and the invisible world. The third part includes papers on specific sources of light, the discoveries of which have revolutionized optical technologies in our lifetime. They discuss the nature and the characteristics of lasers, Solid-state lighting based on the Light Emitting Diode (LED) technology, and finally modern electron optics and its relationship to the Muslim golden age in science. The book’s fourth part discusses various applications of optics and light in today's world, including biophotonics, art, optical communication, nanotechnology, the eye as an optical instrument, remote sensing, and optics in medicine. In turn, the last part focuses on quantum optics, a modern field that grew out of the interaction of light and matter. Topics addressed include atom optics, slow, stored and stationary light, optical tests of the foundation of physics, quantum mechanical properties of light fields carrying orbital angular momentum, quantum communication, and Wave-Particle dualism in action.

Oxygen Transport to Tissue XXXIX
Author : Howard J. Halpern,Joseph C. LaManna,David K. Harrison,Boris Epel
Publisher : Springer
Release Date : 2017-07-06
ISBN 10 : 3319552317
Pages : 435 pages

This volume presents all aspects of delivery of oxygen to tissues and tumors in peer reviewed short articles. Both overview and the most recent, advanced techniques for oxygen measurement are presented. Articles and peer reviewers include those from leaders in their field. Topics such as molecular signaling in the organismal and tumor response to low levels of local oxygenation, hypoxia inducible factor (HIF) , cancer metabolism, individual human and animal response to oxygen changes monitored by optical/near infrared spectroscopy/ tomography to novel electron resonance spectroscopy and spectroscopic imaging, instrumentation, progress in blood substitute research, retinal physiology, cellular hypoxia, mitochondrial function; brain oxygenation and function; oxygen transport in sports, hypoxia in diseases and clinical care. Chapters 10 and 19 of this book are open access under a CC BY 4.0 license.

Applications of Dispersive Optical Spectroscopy Systems
Author : Wilfried Neumann
Publisher : N.A
Release Date : 2015-01-01
ISBN 10 : 9781628413731
Pages : 196 pages

Bridging the gap between a theoretical background in applied spectroscopy systems and practical recommendations, Applications of Dispersive Optical Spectroscopy Systems addresses the requirements, recommended configurations, and the justification and verification of systems for various applications. Topics include the selection and combination of components to fulfill requirements, as well as methods to justify the functionality. This book is suitable for students, engineers, and scientists looking for a concise text that provides background knowledge, perspective, and technical details for system designers and an easy-to-read compendium for specialists