molecular imaging

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Molecular Imaging
Author : Ralph Weissleder
Publisher : PMPH-USA
Release Date : 2010
ISBN 10 : 9781607950059
Pages : 1357 pages

The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Molecular Imaging in Oncology
Author : Otmar Schober,Burkhard Riemann
Publisher : Springer Science & Business Media
Release Date : 2012-11-28
ISBN 10 : 3642108539
Pages : 416 pages

The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.

Molecular Imaging
Author : Brian D. Ross,Sanjiv S. Gambhir
Publisher : Academic Press
Release Date : 2021-08-15
ISBN 10 : 9780128163863
Pages : 1500 pages

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to the understanding of cell physiology and pathophysiology. The field of molecular imaging of living subjects continues to expand and has seen dramatic advances in chemistry, engineering and biomedical applications. Molecular Imaging: Principles and Practice, Second Edition provides the first point of entry to the research for all scientists interested in this multi-disciplinary field. Molecular imaging is very diverse: new investigators, collaborators, and students entering this field need an authoritative reference to bring this field together. Editors Brian Ross and Sam Gambhir designed this revision precisely to fill this need. The most authoritative and effective resource available in the field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data within the field Concepts illustrated with over 600 color figures and molecular-imaging examples This edition packed with innovative science, including: Light sheet fluorescence microscopy (LSFM); Mass Spectrometry Imaging; Combining In vitro and in vivo diagnostics; Raman Imaging; Optogenetics; FDA approval of current imaging agents

Molecular Imaging
Author : Hossein Jadvar,Michael Graham,Heather Jacene
Publisher : Cambridge University Press
Release Date : 2017-10-31
ISBN 10 : 1107621283
Pages : 94 pages

Trace the history, and advances in the field of molecular imaging, with this guide to the visual world of disease.

Molecular Imaging
Author : Ammasi Periasamy,Richard Day
Publisher : Elsevier
Release Date : 2011-04-28
ISBN 10 : 9780080536873
Pages : 312 pages

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided. The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

The Chemistry of Molecular Imaging
Author : Nicholas Long,Wing-Tak Wong,Edmund H. Immergut
Publisher : John Wiley & Sons
Release Date : 2014-12-22
ISBN 10 : 1118093275
Pages : 408 pages

Covering all the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry, The Chemistry of Molecular Engineering focuses primarily on the chemistry of probes and imaging agents, as well as chemical methodology for labelling and bioconjugation. Written by an interdisciplinary team of experts, this book investigates the chemistry of molecular imaging and helps to educate non-chemists already involved in the area of molecular imaging. It addresses all the major modalities and techniques, such as MRI, positron emission tomography, single photon emission computed tomography, ultrasound, and fluorescence/optical imaging.

Molecular Imaging
Author : Jie Tian
Publisher : Springer Science & Business Media
Release Date : 2013-07-23
ISBN 10 : 3642343031
Pages : 699 pages

"Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Targeted Molecular Imaging
Author : Michael J. Welch,William C. Eckelman
Publisher : CRC Press
Release Date : 2012-02-24
ISBN 10 : 1439841950
Pages : 388 pages

Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Molecular Imaging
Author : Bernhard Schaller
Publisher : BoD – Books on Demand
Release Date : 2012-03-16
ISBN 10 : 9535103598
Pages : 402 pages

The present book gives an exceptional overview of molecular imaging. Practical approach represents the red thread through the whole book, covering at the same time detailed background information that goes very deep into molecular as well as cellular level. Ideas how molecular imaging will develop in the near future present a special delicacy. This should be of special interest as the contributors are members of leading research groups from all over the world.

Cardiovascular Molecular Imaging
Author : Robert J. Gropler,David K. Glover,Albert J. Sinusas
Publisher : CRC Press
Release Date : 2007-07-23
ISBN 10 : 1000611442
Pages : 368 pages

Cardiovascular Molecular Imaging is based on a groundbreaking NIH symposium sponsored by the American Society of Nuclear Cardiology. The first all-inclusive guide to the targeted molecular imaging of the cardiovascular system, it includes color illustrations throughout and is packaged with a user-friendly CD-ROM with supplemental material.This refe

Molecular Imaging in Oncology
Author : Martin G. Pomper,Juri G. Gelovani
Publisher : CRC Press
Release Date : 2008-10-13
ISBN 10 : 1000654400
Pages : 744 pages

With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers:instrumentation and techniquescancer imaging

Molecular Imaging
Author : Shankar Vallabhajosula
Publisher : Springer
Release Date : 2009-07-31
ISBN 10 : 9783540767343
Pages : 372 pages

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.