|Author||: Bruno D. Zumbo,Eric K.H. Chan|
|Release Date||: 2014-09-26|
|ISBN 10||: 3319077945|
|Pages||: 327 pages|
This book combines an overview of validity theory, trends in validation practices and a review of standards and guidelines in several international jurisdictions with research synthesis of the validity evidence in different research areas. An overview of theory is both useful and timely, in view of the increased use of tests and measures for decision-making, ranking and policy purposes in large-scale testing, assessment and social indicators and quality of life research. Research synthesis is needed to help us assemble, critically appraise and integrate the overwhelming volume of research on validity in different contexts. Rather than examining whether any given measure is “valid”, the focus is on a critical appraisal of the kinds of validity evidence reported in the published research literature. The five sources of validity evidence discussed are: content-related, response processes, internal structure, associations with other variables and consequences. The 15 syntheses included here, represent a broad sampling of psychosocial, health, medical and educational research settings, giving us an extensive evidential basis to build upon earlier studies. The book concludes with a meta-synthesis of the 15 syntheses and a discussion of the current thinking of validation practices by leading experts in the field.
|Author||: Mark Chang,John Balser,Jim Roach,Robin Bliss|
|Publisher||: CRC Press|
|Release Date||: 2019-03-29|
|ISBN 10||: 1351214527|
|Pages||: 362 pages|
"This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.
|Author||: John W Murphy,Berkeley A. Franz,Jung Min Choi,Karen A. Callaghan|
|Release Date||: 2017-09-30|
|ISBN 10||: 3319618571|
|Pages||: 136 pages|
This progressive resource brings the innovative power of narrative medicine to the forefront of community public health care. Chapters describe community involvement across a continuum of control, from health consultants describing problems and suggesting solutions to health committees designing programs and evaluating results. Narrative strategies to this end, including authentic dialogue and community mapping, are examined in the context of public health and fleshed out with examples of different levels of participation by community members. From the respectful collaboration modeled here, the principles of community public health care can potentially expand beyond the immediate community into other social domains on a greater scale. Included in the coverage: · Narratives, local knowledge, and world entry. · Community and narratives. · What is dialogue? · Storylines, causes, and locus of interventions. · Community mapping tells a story. · The politics of storytelling. Narrative Medicine and Community-Based Health Care and Planning gives health psychologists, sociologists, social workers, and public health administrators realistic practical insights for tapping into the unique resources communities and clients have to offer. This is the next step in the evolution of public health, toward large-scale improvements in care delivery, access to and relevance of services, and patient and community outcomes.
Represents the largest recorded dataset based on human skeletal remains from archaeological sites across the continent of Europe.
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
With thorough updates throughout, Clinical Radiation Oncology provides the most comprehensive, authoritative, and up-to-date information available for treating patients with cancer. From a multidisciplinary perspective, this new edition, edited by Drs. Leonard L. Gunderson and Joel E. Tepper, examines the therapeutic management of specific disease sites based on both single-modality and combined-modality approaches - providing you with the well-rounded, cutting-edge guidance you need to offer the most effective treatments. A consistent chapter format, full-color design, and access to the full text at www.expertconsult.com make reference fast and easy. It is an ideal resource for mastering the latest, most effective techniques and modalities! Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors –many of whom are new to this edition – affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at www.expertconsult.com, along with references, additional images and tables, video clips and more! Stay current with comprehensive updates throughout that include a new chapter on survivorship issues, and additional video clips on treatments such as prostate and penile cancer brachytherapy. Improve outcomes by providing the most effective treatment for each patient with expanded coverage of new modalities and treatment regimens. Understand and comply with the latest staging guidelines.
|Author||: Raj S. Bhopal|
|Publisher||: OUP Oxford|
|Release Date||: 2013-12-19|
|ISBN 10||: 0191644803|
|Pages||: 408 pages|
The globalization of trade and increasing international travel and migration poses huge challenges for health practitioners and policy makers who have to meet legal and policy obligations to provide health care of equal quality and effectiveness for all. Migration, Ethnicity, Race, and Health in Multicultural Societies provides an accessible introduction to the complex issues of race, ethnicity and minority populations. The book explains the process of migration and the uses and misuses of the key concepts of race and ethnicity, illustrating their strengths and weaknesses in epidemiology, policy making, health service planning, research, health care and health promotion. Including many examples from around the world to demonstrate the theory in a practical way, and written in a clear and straightforward style with all terminology explained, this is an ideal book for all students and professionals in the field of migration, ethnicity and race in the health care context. "Bhopal's important and comprehensive Ethnicity, Race, and Health in Multicultural Societies challenges us to achieve better health for ethnic minority populations... provides critical and thought-provoking insights into public health research and clinical practice with multi-ethnic populations." - The Lancet "Professor Bhopal has produced an invaluable addition to the growing mountain of resources on ethnicity and health...One of the greatest merits of this text is that it is written by someone who has been involved in high-quality research on ethnicity and health in many contexts and for many years. The author therefore is able to draw upon first-hand experience or research with which he has been associated, as well as providing examples from other key players in the field." - Diversity in Health and Social Care
|Author||: Søren Hess|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2014-12-27|
|ISBN 10||: 0323341993|
|Pages||: 145 pages|
Part II of the important issue on Contribution of FDG to Modern Medicine. Articles will include: FDG in infectious/inflammatory diseases, FDG in cardiovascular disease, Assesment of treatment response using PET, PET based chemotherapy response assessment, PET based radiation therapy planning, PET based interventional radiology, PET/MRI, Evolving and upcoming applications of FDG-PET in medicine, and more.
Several years have passed since the sequencing of the human genome and what might be called "the post-genomic era" has begun. Of course, there are many different genomes and the term "post-genomic" does not necessarily imply the human genome. However, it is the data encoded in the human genome that hold the promise to be of practical importance in a wide range of biomedical applications. The sequencing and preliminary annotations of the human genome provided an incredible amount of the raw, largely unprocessed information. Coupled with the millions of publications on human physiology already available in public databases, it is clear that certain informational strategies should be adopted for the retrieval, analysis and representation of these data. Among biological sciences, bioinformatics is a specific branch that deals with managing complexities in the biological information. However, the bioinformatics is in no way restricted to the compilation of large databases or elaboration of sophisticated software. The methods of bioinformatics can greatly assist the generation of productive hypotheses that allow subsequent experimental testing followed by confirmation or disapproval. The main idea behind the present volume is not worrying about the steadily growing amounts of biomedical information or about the relative quality of it. This volume, as well as the entire book series, is based on the purpose-oriented attitude: how to make a good use of this information in particular research projects.
|Author||: Richard Jason Whitt|
|Release Date||: 2008|
|Pages||: 398 pages|
|Author||: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Diagnostic Error in Health Care|
|Publisher||: National Academies Press|
|Release Date||: 2016-01-29|
|ISBN 10||: 0309377692|
|Pages||: 472 pages|
Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001) finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.
Physical Medicine and Rehabilitation presents today’s best physiatry knowledge and techniques, ideal for the whole rehabilitation team. This trusted reference delivers the proven science and comprehensive guidance you need to offer every patient maximum pain relief and optimal return to function. In this new edition, Dr. Randall L. Braddom covers current developments in interventional injection procedures, the management of chronic pain, integrative medicine, recent changes in the focus of stroke and brain injury rehabilitation, and much more. Access the complete contents online along with 1000 self-assessment questions at www.expertconsult.com. Gain a clear visual understanding of important concepts thanks to 1400 detailed illustrations—1000 in full color. Find and apply the information you need easily with each chapter carefully edited by Dr. Braddom and his associates for consistency, succinctness, and readability. Access the fully searchable text online at Expert Consult, as well as 1000 self-assessment questions. Master axial and peripheral joint injections through in-depth coverage of the indications for and limitations of these therapies. Make optimal use of ultrasound in diagnosis and treatment. Get a broader perspective on your field from a new chapter on PM&R in the international community.
|Author||: Jeanne Mager Stellman|
|Publisher||: International Labour Organization|
|Release Date||: 1998|
|ISBN 10||: 9789221098140|
|Pages||: 1174 pages|
Revised and expanded, this edition provides comprehensive coverage of occupational health and safety. A new CD-ROM version is available which provides the benefits of computer-assisted search capabilities.
Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC, Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive, dependable guidance you need to effectively diagnose and manage even the most challenging sleep disorders. Updates to genetics and circadian rhythms, occupational health, sleep in older people, memory and sleep, physical examination of the patient, comorbid insomnias, and much more keep you current on the newest areas of the field. A greater emphasis on evidence-based approaches helps you make the most well-informed clinical decisions. And, a new more user-friendly, full-color format, both in print and online, lets you find the answers you need more quickly and easily. Whether you are preparing for the new sleep medicine fellowship examination, or simply want to offer your patients today's best care, this is the one resource to use! Make optimal use of the newest scientific discoveries and clinical approaches that are advancing the diagnosis and management of sleep disorders.