|Author||: Xinyu Liu,Yu Sun|
|Publisher||: Academic Press|
|Release Date||: 2021-09-01|
|ISBN 10||: 0128242434|
|Pages||: 340 pages|
Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms is the first book providing a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. The biophysical studies range from cell mechanics to neural science of worms and Drosophila. This book helps readers to understand the fundamentals in the development of these tools and learn the most recent advances in cellular and organismal biophysics enabled by these technologies. Comprehensive coverage of the micro and nano systems technology and application to biophysical studies of cells and small organisms Highlight of the most recent advances in cellular and organismal biophysics enabled by micro and nano systems Insightful outlook on future directions and trends in each chapter covering a sub-area of the book topic
Combining robotics with nanotechnology, this ready reference summarizes the fundamentals and emerging applications in this fascinating research field. This is the first book to introduce tools specifically designed and made for manipulating micro- and nanometer-sized objects, and presents such examples as semiconductor packaging and clinical diagnostics as well as surgery. The first part discusses various topics of on-chip and device-based micro- and nanomanipulation, including the use of acoustic, magnetic, optical or dielectrophoretic fields, while surface-driven and high-speed microfluidic manipulation for biophysical applications are also covered. In the second part of the book, the main focus is on microrobotic tools. Alongside magnetic micromanipulators, bacteria and untethered, chapters also discuss silicon nano- and integrated optical tweezers. The book closes with a number of chapters on nanomanipulation using AFM and nanocoils under optical and electron microscopes. Exciting images from the tiniest robotic systems at the nano-level are used to illustrate the examples throughout the work. A must-have book for readers with a background ranging from engineering to nanotechnology.
|Author||: National Research Council,Division on Engineering and Physical Sciences,Space Studies Board,Commission on Physical Sciences, Mathematics, and Applications,Steering Group for the Workshop on Size Limits of Very Small Microorganisms|
|Publisher||: National Academies Press|
|Release Date||: 1999-09-13|
|ISBN 10||: 9780309172745|
|Pages||: 164 pages|
How small can a free-living organism be? On the surface, this question is straightforward-in principle, the smallest cells can be identified and measured. But understanding what factors determine this lower limit, and addressing the host of other questions that follow on from this knowledge, require a fundamental understanding of the chemistry and ecology of cellular life. The recent report of evidence for life in a martian meteorite and the prospect of searching for biological signatures in intelligently chosen samples from Mars and elsewhere bring a new immediacy to such questions. How do we recognize the morphological or chemical remnants of life in rocks deposited 4 billion years ago on another planet? Are the empirical limits on cell size identified by observation on Earth applicable to life wherever it may occur, or is minimum size a function of the particular chemistry of an individual planetary surface? These questions formed the focus of a workshop on the size limits of very small organisms, organized by the Steering .Group for the Workshop on Size Limits of Very Small Microorganisms and held on October 22 and 23, 1998. Eighteen invited panelists, representing fields ranging from cell biology and molecular genetics to paleontology and mineralogy, joined with an almost equal number of other participants in a wide-ranging exploration of minimum cell size and the challenge of interpreting micro- and nano-scale features of sedimentary rocks found on Earth or elsewhere in the solar system. This document contains the proceedings of that workshop. It includes position papers presented by the individual panelists, arranged by panel, along with a summary, for each of the four sessions, of extensive roundtable discussions that involved the panelists as well as other workshop participants.
Tissue Repair, Contraction and the Myofibroblast summarizes the latest findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. Coverage shows that the myofibroblast is responsible for the development of hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma. Reviews the cell biology and pathology of the myofibroblast as well as mechanisms of fibrosis evolution in many organs and tissues.
This textbook explains the fundamental aspects of nanotechnology and fills the gap between bio-inspired nanotechnological systems and functionality of living organisms, introducing new insights to their physicochemical, biophysical and thermodynamic behaviour. Addressed to all those involved in recent advances in pharmaceutics, this book is divided in three major parts: Part A refers to the physicochemical and thermodynamics aspects of nanosystems, wherein their biophysical behaviour is correlated with that of the cells of living organisms; Part B refers to the application of nanotechnology in imaging, diagnostics and therapeutics; Part C is focused on issues regarding safety and nanotoxicity of nanosystems, and the regulatory framework that surrounds these. The text promotes the concept that biophysics, thermodynamics and nanotechnology are considered to be emerging tools that, when approached within regulatory boundaries, provide new and integrated knowledge for the production of new medicines.
The objective of this book is to provide the fundamental comprehension of a broad range of topics in an integrated volume such that readership hailing from diverse disciplines can rapidly acquire the necessary background for applying it in pertinent research and development field.
|Author||: Costas Demetzos,Natassa Pippa|
|Release Date||: 2019-03-04|
|ISBN 10||: 9811309892|
|Pages||: 475 pages|
This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism. In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.
By employing a combination of approaches from several disciplines the authors elucidate the principles of a variety of biomechanical systems that rely on frictional surfaces or adhesive secretions to attach parts of the body to one another or to attach organisms to a substrate. This account provides an excellent starting point for engineers and physicists working with biological systems and for biologists studying friction and adhesion. It will also serve as a valuable introduction for graduate students entering this interdisciplinary field of research.
Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers
Nanoparticles are considered to be the building blocks for nanotechnology and are referred to as the particles having more than one dimension of the order of 100 nm or less.The nanostructured materials are being offered as better built, long lasting, cleaner, safer, and smarter products for use in communications, medicine, transportation, agriculture and other industries. Topics in molecular recognition, biomolecule-nanocrystal conjugates as fluorescence label for biological cells, and DNA-mediated groupings of nanocrystals are widespread, intriguing researchers from both biological and engineering fields. The diversity of nanotechnology covers fields from biology to material science, physics to chemistry, and other fields with variety of specialties. Controlled size, shape, composition, crystallinity, and structure-dependent properties of nanoparticles govern the unique properties of nanotechnology. The controlled biosynthesis of nanoparticles is of high scientific and technological interest as the microorganisms grab target ions from their environment and then turn the metal ions into the element metal through enzymatic mechanism generated through their cellular (Intra/ Extra) activities. The project aims to introduce the basics and advancements made so far in the field of biosynthesis of nanoparticles for graduate students and researchers around the world. The main aims are to (a) introduce the reader to the variety of microorganisms and their ability to synthesize the nanoparticles, (b) provide an overview of the methodologies applied to biosynthesize the variety of nanoparticles of medical and commercial uses, (c) provide a literature review on diversity of microorganisms able to synthesize nanoparticles of different types, (d) to discuss the regulatory mechanisms in microorganism able to synthesize variety of nanoparticles, (e) discuss experimental design problems associated with the controlled biosynthesis of nanoparticles, (f) discuss the stability and toxicity of nanoparticles in varying environment towards their therapeutic implications. The regulations, challenges and implications of biosynthesized nanoparticles for commercial significance will also represent among the main sections of the book. These aims will be organized by invited research/ review articles from renowned researchers exploring biosynthesis of variety of nanoparticles, and differ in length and number of chapters, with the literature review section containing the bulk of the text.