isocoumarin thiaisocoumarin and phosphaisocoumarin

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Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin
Author : Sarbani Pal,Manojit Pal
Publisher : Elsevier
Release Date : 2018-10-16
ISBN 10 : 0128154462
Pages : 216 pages

Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin: Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications gives an overview of the various aspects of this class of heterocycle, with a major focus on synthesis and biological activity. Aromatic δ lactones or isocoumarins with thiaisocoumarins, phosphaisocoumarins and a-pyranone fused with a heteroaryl ring constitute an important class of heterocyclic compounds. This book provides the methods applied for the synthesis of thiaisocoumarins, phosphaisocoumarins, and a-pyranone fused with a heteroaryl ring. It is useful to medicinal and natural product chemists who want to synthesize target molecules and develop cutting-edge technologies to provide better solutions to researchers. Features an overview of isocoumarins and their role in pharmaceutical research Presents a template for the design, discovery and development of new and potential drugs in various therapeutic areas Includes comprehensive coverage of the synthesis of isocoumarins, from traditional methods, to transition metal catalyzed methods Looks at future applications for these important compounds in the areas of drug discovery and pharmaceutical research

The Chemistry of Heterocycles
Author : Vishnu Ji Ram,Arun Sethi,Mahendra Nath,Ramendra Pratap
Publisher : Elsevier
Release Date : 2019-06-05
ISBN 10 : 0081011911
Pages : 500 pages

Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described. Gives in-depth, clear information about various systems of nomenclature along with widely acceptable IUPAC system for naming various classes of heterocycles Provides complete information about natural occurrences, synthesis, chemical reactivity, pharmacological importance of heterocycles and their application in material science Highly relevant for graduate students and researchers, providing updated information about various isolated and fused N,O and,S containing heterocycles

Hypervalent Iodine in Organic Synthesis
Author : A. Varvoglis
Publisher : Academic Press
Release Date : 1996-11-14
ISBN 10 : 0080534368
Pages : 223 pages

This book describes the fascinating chemistry of the many kinds of organic compounds of hypervalent iodine. Each chapter deals with a particular iodine compound or families of compounds which have been used as reagents in a plethora of useful transformations. These include assorted oxidation, such as with the precious Dess-Martin reagent as well as with a wide range of further reactions. Prominent features of hypervalent iodine reagents derived from iodobenzene are: ready availability, operational simplicity, mild reaction conditions, and high efficiency. They are environmentally safe and can be recycled. New species may be easily prepared by introducing substituents in the benzene ring or changing the ligand attached to iodine. Their combination with other reagents broadens considerably their synthetic potential. Today, no synthetic chemist can afford to ignore the valuable hypervalentiodine reagents. Key Features * Features up-to-date coverage of a wide range of topics * Includes many tables featuring a diversity of reactivity, and a comprehensive index * Acts as a comprehensive, up-to-date reference on all aspects of hypervalent iodine chemistry * Contains a section on unusual efficiency of hypervalent iodine reactions

Approaches to Design and Synthesis of Antiparasitic Drugs
Author : N. Anand,S. Sharma†
Publisher : Elsevier
Release Date : 1997-07-10
ISBN 10 : 9780080527529
Pages : 510 pages

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Principles of Organic Chemistry
Author : Robert J. Ouellette,J. David Rawn
Publisher : Academic Press
Release Date : 2015-02-13
ISBN 10 : 0128026340
Pages : 496 pages

Class-tested and thoughtfully designed for student engagement, Principles of Organic Chemistry provides the tools and foundations needed by students in a short course or one-semester class on the subject. This book does not dilute the material or rely on rote memorization. Rather, it focuses on the underlying principles in order to make accessible the science that underpins so much of our day-to-day lives, as well as present further study and practice in medical and scientific fields. This book provides context and structure for learning the fundamental principles of organic chemistry, enabling the reader to proceed from simple to complex examples in a systematic and logical way. Utilizing clear and consistently colored figures, Principles of Organic Chemistry begins by exploring the step-by-step processes (or mechanisms) by which reactions occur to create molecular structures. It then describes some of the many ways these reactions make new compounds, examined by functional groups and corresponding common reaction mechanisms. Throughout, this book includes biochemical and pharmaceutical examples with varying degrees of difficulty, with worked answers and without, as well as advanced topics in later chapters for optional coverage. Incorporates valuable and engaging applications of the content to biological and industrial uses Includes a wealth of useful figures and problems to support reader comprehension and study Provides a high quality chapter on stereochemistry as well as advanced topics such as synthetic polymers and spectroscopy for class customization

Scientific and Technical Aerospace Reports
Author : N.A
Publisher : N.A
Release Date : 1964
ISBN 10 :
Pages : 329 pages

Fluorescent Analogs of Biomolecular Building Blocks
Author : Marcus Wilhelmsson
Publisher : John Wiley & Sons
Release Date : 2016-04-04
ISBN 10 : 1118175867
Pages : 448 pages

The first book to serve as both an introduction and state-of-the-art biophysical applications of fluorescent probe, Fluorescent Analogues of Biomolecular Building Blocks focuses on design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks. Featuring a chapter by Nobelist Roger Tsien, the text focuses on designing fluorescent probes for the four major families of macromolecular building blocks and summarizes the most important and general contributions discussing fluorescent probes that were designed to shed light on biological processes.

Natural Gas Conversion V
Author : A. Parmaliana,D. Sanfilippo,F. Frusteri,A. Vaccari,F. Arena
Publisher : Elsevier
Release Date : 1998-09-17
ISBN 10 : 9780080537306
Pages : 978 pages

On January 1988, the ascertained and economically accessible reserves of Natural Gas (NG) amounted to over 144,000 billion cubic meters worldwide, corresponding to 124 billion tons of oil equivalents (comparable with the liquid oil reserves, which are estimated to be 138 billion TOE). It is hypothesized that the volume of NG reserve will continue to grow at the same rate of the last decade. Forecasts on production indicate a potential increase from about 2,000 billion cubic meters in 1990 to not more than 3,300 billion cubic meters in 2010, even in a high economic development scenario. NG consumption represents only one half of oil: 1.9 billion TOE/y as compared to 3.5 of oil. Consequently, in the future gas will exceed oil as a carbon atom source. In the future the potential for getting energetic vectors or petrochemicals from NG will continue to grow. The topics covered in Natural Gas Conversion V reflect the large global R&D effort to look for new and economic ways of NG exploitation. These range from the direct conversion of methane and light paraffins to the indirect conversion through synthesis gas to fuels and chemicals. Particularly underlined and visible are the technologies already commercially viable. These proceedings prove that mature and technologically feasible processes for natural gas conversion are already available and that new and improved catalytic approaches are currently developing, the validity and feasibility of which will soon be documented. This is an exciting area of modern catalysis, which will certainly open novel and rewarding perspectives for the chemical, energy and petrochemical industries.

Handbook of Heterocyclic Chemistry
Author : Alan R. Katritzky
Publisher : Elsevier
Release Date : 2017-01-31
ISBN 10 : 1483293424
Pages : 568 pages

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Key Heterocycle Cores for Designing Multitargeting Molecules
Author : Om Silakari
Publisher : Elsevier
Release Date : 2018-06-11
ISBN 10 : 0081021054
Pages : 436 pages

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

Fundamentals of Biologicals Regulation
Author : Rebecca Sheets
Publisher : Academic Press
Release Date : 2017-12-13
ISBN 10 : 0128094435
Pages : 450 pages

Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. This book will provide multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions. With numerous case studies, learning activities, and real-world examples across several classes of biotechnological products, this book is a valuable and comprehensive resource for graduate students, professors, regulatory officials, and industry scientists working with biologicals. Provides a broad overview and introduction to the regulatory processes, from product development pathways, through clinical trials and product development stages and beyond Includes FDA, EMA, ICH, and WHO recommendations and guidelines so readers can compare and contrast the different regulatory regions with their expectations and understand why they are different Contains chapters on some of the exceptions to the process including how biosimilars and in vitro diagnostics are regulated Includes numerous case studies, learning activities, and real-world examples across several classes of biotechnological products

Fungal Metabolites
Author : W. B. Turner,D. C. Aldridge
Publisher : N.A
Release Date : 1971
ISBN 10 :
Pages : 446 pages

Catalytic Amination for N-Alkyl Amine Synthesis
Author : Feng Shi,Xinjiang Cui
Publisher : Academic Press
Release Date : 2018-03-14
ISBN 10 : 0128122854
Pages : 206 pages

Catalytic Amination for N-Alkyl Amine Synthesis provides a useful survey of this key type of reaction for chemistry researchers in academia and industry. Beginning with an introduction to amination and the development of the field, the book focuses on useful and high potential methods, such as the catalytic amination of alcohol with homogeneous and heterogeneous catalysts, the coupling reaction of olefin and amine, and the reductive amination of carbon dioxide with different reducing agents. The work also discusses two key examples of one-pot synthesis, the oxidative amination of alkane and amine and synthesis of N-alkyl amine with nitrobenzene and nitrile as starting materials. Valuable for chemists, materials scientists, chemical engineers and others, the book offers a unique overview of this growing area and its future possibilities. Describes the catalytic amination of alcohol with homogeneous and heterogeneous catalysts Discusses the one-pot oxidative amination of alkane and amine Explores the application of ammonia as the N-source in amination reaction to avoid primary or secondary amine synthesis

Organic Chemistry Study Guide
Author : Robert J. Ouellette,J. David Rawn
Publisher : Elsevier
Release Date : 2015-04-30
ISBN 10 : 012801864X
Pages : 614 pages

Organic Chemistry Study Guide: Key Concepts, Problems, and Solutions features hundreds of problems from the companion book, Organic Chemistry, and includes solutions for every problem. Key concept summaries reinforce critical material from the primary book and enhance mastery of this complex subject. Organic chemistry is a constantly evolving field that has great relevance for all scientists, not just chemists. For chemical engineers, understanding the properties of organic molecules and how reactions occur is critically important to understanding the processes in an industrial plant. For biologists and health professionals, it is essential because nearly all of biochemistry springs from organic chemistry. Additionally, all scientists can benefit from improved critical thinking and problem-solving skills that are developed from the study of organic chemistry. Organic chemistry, like any "skill", is best learned by doing. It is difficult to learn by rote memorization, and true understanding comes only from concentrated reading, and working as many problems as possible. In fact, problem sets are the best way to ensure that concepts are not only well understood, but can also be applied to real-world problems in the work place. Helps readers learn to categorize, analyze, and solve organic chemistry problems at all levels of difficulty Hundreds of fully-worked practice problems, all with solutions Key concept summaries for every chapter reinforces core content from the companion book

Anionic Annulations in Organic Synthesis
Author : Dipakranjan Mal
Publisher : Elsevier
Release Date : 2018-10-25
ISBN 10 : 0128138017
Pages : 464 pages

Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the best annulations for the construction of cyclic structures and their applications in the total synthesis of functional molecules. The reactions described in the work are particularly useful for the synthesis of polyoxygenated polycyclic compounds, including tetracyclines, angucyclines, uncialamycins, and lignans, among other compounds. Included in detail are the Hauser, Robinson, Sammes and Meyers annulations, all of which can be effectively used to construct substrates with complex molecular structures. This work provides the tools to master anionic organic chemistry, ortho-lithiation, lateral lithaition/metalation and organic selectivity issues, like chemoselectivity, regioselectivity and stereoselectivity. This book is a valuable resource for organic chemists, researchers and students seeking a complete and detailed understanding of anionic annulations. Provides a comprehensive review of anionic cyclization for chemical construction of a variety of cyclic scaffolds involved in many kinds of biologically active natural products and pharmaceutical drugs Serves as a useful tool to academic and industrial researchers working on the synthesis of cyclic compounds as their targets Includes many examples of anionic annulations and practical information on how to use them in research and industry Features anionic annulations that are particularly useful for the synthesis of polyoxygenated polycyclic compounds, including tetracyclines, angucyclines, uncialamycins and lignans

Transition Metal Catalyzed Furans Synthesis
Author : Xiao-Feng Wu
Publisher : Elsevier
Release Date : 2015-09-08
ISBN 10 : 0128040726
Pages : 116 pages

Transition Metal Catalyzed Furans Synthesis provides an overview of Furans, describing properties of these heterocycle compounds and covering traditional synthetic procedures for them. This book then explores catalyzed procedures for Furans synthesis in greater detail and depth then is currently available in published Reviews. Finally, this useful short work discusses natural products and bio-active compounds containing Furans, information of particular interest for their applications to medicinal and pharmaceutical chemistry. The short series Transition Metal Catalyzed Heterocycles Synthesis Series, authored by Xiao-Feng Wu, summarizes recent achievements on heterocycles synthesis with transition metal as the catalysts, with each volume dedicated to one heterocycle compound. Brief, focused review of this active research area, Furans synthesis via transition metal catalysis Useful coverage of furans properties and procedures, as well as relevant Furan-containing natural products First volume in short work series, "Transition Metal-Catalyzed Heterocycles Synthesis"

Analysis of Marine Samples in Search of Bioactive Compounds
Author : N.A
Publisher : Elsevier
Release Date : 2014-08-26
ISBN 10 : 0444633812
Pages : 312 pages

Seas and oceans offer a wide range of temperature, pressure, light and chemical conditions thus allowing a wide diversity of marine organisms from shallow coastal waters to the deep ocean. These resources can be used to obtain new products and develop services, and in turn help to provide solutions to the challenges that affect our planet, including offering a sustainable supply of food and energy, new industrial materials and processes, new bioactive compounds, and new health treatments. Marine compounds have been identified as having antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. The major sources of these bioactive compounds are marine sponges, coelenterates, and microorganisms, followed by algae, echinoderms, tunicates, molluscs, and bryozoans. The discovery of bioactive compounds from marine samples is a hot topic considering the current need for sustainable use of marine resources. This book is a comprehensive overview of the analytical techniques employed in the discovery and characterization of bioactive compounds isolated from (all possible) marine samples and gives future perspectives of analytical methodologies. This overview includes an assessment of the sampling and preparation of extracts, the separation and isolation of bioactive compounds, their structural characterization and the application of bioassays in the discovery of bioactive compounds. Comprehensive coverage of analytical techniques and applications Clear diagrams to adequately support important topics Real examples of applications of analytical techniques in the search for new bioactive compounds

Pyrolysis of Organic Molecules
Author : Serban C. Moldoveanu
Publisher : Elsevier
Release Date : 2009-09-16
ISBN 10 : 9780080932156
Pages : 744 pages

Pyrolysis of Organic Molecules with Applications to Health and Environmental Issues, the 28th volume in the Techniques and Instrumentation in Analytical Chemistry series, gives a systematic and comprehensive description of pyrolysis of non-polymeric organic molecules. Pyrolysis is involved in many practical applications as well as in many common human activities, but harmful compounds can be generated in the process. The study of pyrolysis and of the formation of undesirable compounds as a result of pyrolytic processes is of considerable interest to chemists, chemical engineers, and toxicologists. Pyrolysis results for compounds not previously studied or reported Updated information from a large body of results published on pyrolysis of individual compounds or classes of compounds Information on mechanisms and kinetics of numerous pyrolytic processes

Biological Inorganic Chemistry
Author : Robert R. Crichton
Publisher : Elsevier
Release Date : 2007-12-11
ISBN 10 : 9780080556222
Pages : 381 pages

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment. Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on. Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject. Many colour illustrations. Enables easier visualization of molecular mechanisms Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters

EPR in the 21st Century
Author : Asako Kawamori,Jun Yamauchi,Hitoshi Ohta
Publisher : Elsevier
Release Date : 2002-07-01
ISBN 10 : 9780080539720
Pages : 852 pages

The Proceedings in this volume are a refereed selection of presentations from The Third Asia-Pacific EPR/ESR Symposium (APES'01), held in Kobe, Japan from October 29 to November 1, 2001. Participants from 20 countries from Asia, Australia, Europe, North and South America presented 210 papers, of which 132 are included here. These Proceedings are also a blueprint for development of electron paramagnetic resonance (EPR) / electron spin resonance (ESR) in the Asia-Pacific region in the 21st century. The Symposium reflected a variety of research fields developed over half a century and focuses especially on the most recent developments, such as high-field and high-frequency EPR, which are envisaged to be further developed and applied to various fields in the 21st century. All sessions consisted of Plenary, Invited and Contributed presentations. The Plenary presentations aimed at summarizing the overall developments. Invited presentations, reviewing the most recent developments, and Contributed ones, dealing with original research recently carried out in the EPR/ESR area, were given in one of three parallel sessions. The unique research works presented cover various fields and reflect the existing diversity of applications of the EPR/ESR techniques.