introduction to spatial mapping of biomolecules by imaging mass spectrometry

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Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry
Author : Bindesh Shrestha
Publisher : Elsevier
Release Date : 2020-11-15
ISBN 10 : 9780128189986
Pages : 300 pages
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Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry introduces scientists to IMS, describing its many applications for diverse classes of biomolecules. The book is divided into two sections, with the first building a foundation of IMS knowledge by introducing sample preparation, visualization guidelines, molecule identification, quantification, and software and hardware tools. The second section contains chapters focused on each biomolecule class (sugars, polar metabolites, and so on). All chapters include an introduction/background, review of complementary non-IMS techniques, a summary of successful IMS case studies with illustrative figures, a table (showing tissue, condition, ionization modality, and more), and future directions. The second part of the book can be used by both novices and experts looking for a quick deep-dive into IMS for a specific class of molecule used in their research. Provides the introductory foundations of Imaging Mass Spectrometry for those new to the technique Organized by molecule class to facilitate a quick, deep-dive, allowing researchers to immediately apply these techniques to their work Includes a table in every molecule class chapter, summarizing the IMS experiments done for each class of molecules

Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism
Author : Joseph Banoub
Publisher : Springer
Release Date : 2014-11-03
ISBN 10 : 9401792380
Pages : 291 pages
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This NATO-ASI installment is designed to provide an advanced overview for doctoral and post-doctoral candidates of the state-of-the-art technologies for bio-detection. The main objective of the work aims at providing readers with the latest developments necessary to successfully understand the CBRN Agents and their associated biotechnologies. The core methods focused on are mass spectrometry (including chromatographic and electrophoretic separation) and comparisons to spectroscopic, immunological and molecular analysis of chemical, biological and nuclear agents.

Biocomputing 2007
Author : N.A
Publisher : World Scientific
Release Date : 2006-12-11
ISBN 10 : 9812704175
Pages : 507 pages
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The Pacific Symposium on Biocomputing (PSB) 2007 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2007 will be held January 3-7, 2007 at the Grand Wailea, Maui. Tutorials will be offered prior to the start of the conference.PSB 2007 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Statistical Analysis of Proteomics, Metabolomics, and Lipidomics Data Using Mass Spectrometry
Author : Susmita Datta,Bart J. A. Mertens
Publisher : Springer
Release Date : 2016-12-15
ISBN 10 : 3319458094
Pages : 295 pages
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This book presents an overview of computational and statistical design and analysis of mass spectrometry-based proteomics, metabolomics, and lipidomics data. This contributed volume provides an introduction to the special aspects of statistical design and analysis with mass spectrometry data for the new omic sciences. The text discusses common aspects of design and analysis between and across all (or most) forms of mass spectrometry, while also providing special examples of application with the most common forms of mass spectrometry. Also covered are applications of computational mass spectrometry not only in clinical study but also in the interpretation of omics data in plant biology studies. Omics research fields are expected to revolutionize biomolecular research by the ability to simultaneously profile many compounds within either patient blood, urine, tissue, or other biological samples. Mass spectrometry is one of the key analytical techniques used in these new omic sciences. Liquid chromatography mass spectrometry, time-of-flight data, and Fourier transform mass spectrometry are but a selection of the measurement platforms available to the modern analyst. Thus in practical proteomics or metabolomics, researchers will not only be confronted with new high dimensional data types—as opposed to the familiar data structures in more classical genomics—but also with great variation between distinct types of mass spectral measurements derived from different platforms, which may complicate analyses, comparison, and interpretation of results.

Advances in Imaging and Electron Physics
Author : N.A
Publisher : Academic Press
Release Date : 2012-12-31
ISBN 10 : 0123946352
Pages : 440 pages
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Advances in Imaging and Electron Physics merges two long-running serials--Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains. Contributions from leading authorities Informs and updates on all the latest developments in the field

Pacific Symposium on Biocomputing
Author : N.A
Publisher : N.A
Release Date : 2007
ISBN 10 :
Pages : 329 pages
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Advanced Mass Spectrometry for Food Safety and Quality
Author : N.A
Publisher : Elsevier
Release Date : 2015-05-08
ISBN 10 : 0444633928
Pages : 734 pages
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Advanced Mass Spectrometry for Food Safety and Quality provides information on recent advancements made in mass spectrometry-based techniques and their applications in food safety and quality, also covering the major challenges associated with implementing these technologies for more effective identification of unknown compounds, food profiling, or candidate biomarker discovery. Recent advances in mass spectrometry technologies have uncovered tremendous opportunities for a range of food-related applications. However, the distinctive characteristics of food, such as the wide range of the different components and their extreme complexity present enormous challenges. This text brings together the most recent data on the topic, providing an important resource towards greater food safety and quality. Presents critical applications for a sustainable, affordable and safe food supply Covers emerging problems in food safety and quality with many specific examples. Encompasses the characteristics, advantages, and limitations of mass spectrometry, and the current strategies in method development and validation Provides the most recent data on the important topic of food safety and quality

Lipid Analysis
Author : W. W. Christie,X Han
Publisher : Elsevier
Release Date : 2010-01-10
ISBN 10 : 0857097865
Pages : 448 pages
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This well-known and highly successful book was first published in 1973 and has been completely re-written in subsequent editions (published in 1982 and 2003). This new Fourth Edition has become necessary because of the pace of developments in mass spectrometry of intact lipids, which has given recognition of lipid analysis and ‘lipidomics’ as a distinct science. To bring the book up to date with these developments, author William W. Christie is joined by co-author Xianlin Han. Although devoting considerable space to mass spectrometry and lipidomics, Lipid analysis remains a practical guide, in one volume, to the complexities of the analysis of lipids. As in past editions, it is designed to act as a primary source, of value at the laboratory bench rather than residing on a library shelf. Lipid analysis deals with the isolation, separation, identification and structural analysis of glycerolipids, including triacylglycerols, phospholipids, sphingolipids, and the various hydrolysis products of these. The chapters follow a logical sequence from the extraction of lipids to the isolation and characterization of particular lipid classes and of molecular species of each, and to the mass spectrometric analysis of lipids and lipidomics. The new influence of mass spectrometry is due mainly to the development of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). Most emphasis in this book is placed on ESI, which is enabling structural characterization of different lipid classes and the identification of novel lipids and their molecular species.

ToF-SIMS
Author : J. C. Vickerman,David Briggs
Publisher : IM Publications
Release Date : 2013
ISBN 10 : 1906715173
Pages : 732 pages
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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is the most versatile of the surface analysis techniques that have been developed during the last 30 years. This is the Second Edition of the first book ToF-SIMS: Surface analysis by Mass Spectrometry to be dedicated to the subject and the treatment is comprehensive

Applications of Mass Spectrometry Imaging to Cancer
Author : N.A
Publisher : Academic Press
Release Date : 2017-01-19
ISBN 10 : 0128054409
Pages : 312 pages
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Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry
Author : Rainer Cramer
Publisher : Springer
Release Date : 2015-11-09
ISBN 10 : 3319048198
Pages : 286 pages
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This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

Seeds
Author : J. Derek Bewley,Kent Bradford,Henk Hilhorst,hiroyuki nonogaki
Publisher : Springer Science & Business Media
Release Date : 2012-10-23
ISBN 10 : 1461446937
Pages : 392 pages
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This updated and much revised third edition of Seeds: Physiology of Development, Germination and Dormancy provides a thorough overview of seed biology and incorporates much of the progress that has been made during the past fifteen years. With an emphasis on placing information in the context of the seed, this new edition includes recent advances in the areas of molecular biology of development and germination, as well as fresh insights into dormancy, ecophysiology, desiccation tolerance, and longevity. Authored by preeminent authorities in the field, this book is an invaluable resource for researchers, teachers, and students interested in the diverse aspects of seed biology.

Fundamentals and Applications of Fourier Transform Mass Spectrometry
Author : Philippe Schmitt-Kopplin,Basem Kanawati
Publisher : Elsevier
Release Date : 2019-08-11
ISBN 10 : 0128140143
Pages : 778 pages
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Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis

Encyclopedia of Controlled Drug Delivery, 2 Volume Set
Author : Edith Mathiowitz
Publisher : Wiley-Interscience
Release Date : 1999-08-02
ISBN 10 : 9780471148289
Pages : 1061 pages
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Covers all aspects of controlled drug delivery, including human, agricultural and animal applications. The 70 entries, written by an international team of renowned experts, offers A-to-Z coverage of controlled drug delivery systems for researchers in the pharmaceutical and biotechnology industries, agriculture companies, medical device companies, clinical research organizations and medical schools.

Lipidomics
Author : Xianlin Han
Publisher : John Wiley & Sons
Release Date : 2016-04-06
ISBN 10 : 1119085276
Pages : 496 pages
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Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes

Proteomic and Metabolomic Approaches to Biomarker Discovery
Author : Haleem J. Issaq,Timothy D. Veenstra
Publisher : Academic Press
Release Date : 2019-10-24
ISBN 10 : 0128197889
Pages : 504 pages
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Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Visualizing Chemistry
Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Revealing Chemistry through Advanced Chemical Imaging
Publisher : National Academies Press
Release Date : 2006-06-01
ISBN 10 : 9780309164634
Pages : 222 pages
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Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imaging—the ability to visualize molecular structures and chemical composition in time and space as actual events unfold—from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.

Molecular Biology of the Cell
Author : Bruce Alberts
Publisher : N.A
Release Date : 2004
ISBN 10 : 9780815332183
Pages : 329 pages
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Fundamentals of Advanced Omics Technologies: From Genes to Metabolites
Author : N.A
Publisher : Newnes
Release Date : 2014-02-14
ISBN 10 : 0444626700
Pages : 490 pages
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Fundamentals of Advanced Omics Technologies: From Genes to Metabolites covers the fundamental aspects of the new instrumental and methodological developments in omics technologies, including those related to genomics, transcriptomics, epigenetics, proteomics and metabolomics, as well as other omics approaches such as glycomics, peptidomics and foodomics. The principal applications are presented in the following complementary volume. The chapters discuss in detail omics technologies, DNA microarray analysis, next-generation sequencing technologies, genome-wide analysis of methylation and histone modifications, emerging nanotechniques in proteomics, imaging mass spectrometry in proteomics, recent quantitative proteomics approaches, and advances in high-resolution NMR-based metabolomics, as well as MS-based non-targeted metabolomics and metabolome analysis by CE-MS, global glycomics analyses, foodomics, and high resolution analytical tools for quantitative peptidomics. Key aspects related to chemometrics, bioinformatics, data treatment, data integration and systems biology, deep-sequencing data analysis, statistical approaches for the analysis of microarray data, the integration of transcriptome and metabolome data and computational approaches for visualization and integration of omics data are also covered. Covers the latest advances in instrumentation, experimental design, sample preparation, and data analysis Provides thorough explanations and descriptions of specific omics technologies Describes advanced tools and methodologies for data pretreatment, storage, curation and analysis, as well as data integration

Molecular Technologies for Detection of Chemical and Biological Agents
Author : Joseph H. Banoub,Richard M. Caprioli
Publisher : Springer
Release Date : 2017-07-05
ISBN 10 : 9402411135
Pages : 306 pages
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This book describes the latest molecular insights needed to understand the chemical and biological (CB) agents and their associated biotechnologies. Its primary focus is to present and discuss molecular technologies such as mass spectrometry, chemical and biological sensors, chromatographic and electrophoretic separation, and comparisons of spectroscopic, immunological and molecular analyses of chemicals used for the detection of chemical and biological agents and to prevent terrorism. This NATO-ASI book also contributes to the critical assessment of existing knowledge on new and important detection technologies. It helps to identify directions for future research and to promote closer working relationships between scientists from different professional fields.