improving the therapeutic ratio in head and neck cancer

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Improving the Therapeutic Ratio in Head and Neck Cancer
Author : N.A
Publisher : Academic Press
Release Date : 2019-10-04
ISBN 10 : 0128178698
Pages : 376 pages

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment
Author : Mitchell S. Anscher,Kristoffer Valerie
Publisher : Springer
Release Date : 2016-10-20
ISBN 10 : 331945594X
Pages : 305 pages

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

Increasing the Therapeutic Ratio of Radiotherapy
Author : Philip J. Tofilon,Kevin Camphausen
Publisher : Springer
Release Date : 2016-11-21
ISBN 10 : 3319408542
Pages : 280 pages

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

Leibel and Phillips Textbook of Radiation Oncology - E-Book
Author : Richard Hoppe,Theodore L. Phillips,Mack Roach
Publisher : Elsevier Health Sciences
Release Date : 2010-09-09
ISBN 10 : 1437737757
Pages : 1664 pages

Stay on top of the latest scientific and therapeutic advances with the new edition of Leibel and Phillips Textbook of Radiation Oncology. Dr. Theodore L. Phillips, in collaboration with two new authors, Drs. Richard Hoppe and Mack Roach, offers a multidisciplinary look at the presentation of uniform treatment philosophies for cancer patients emphasizing the "treat for cure" philosophy. You can also explore the implementation of new imaging techniques to locate and treat tumors, new molecularly targeted therapies, and new types of treatment delivery. Supplement your reading with online access to the complete contents of the book, a downloadable image library, and more at Gather step-by-step techniques for assessing and implementing radiotherapeutic options with this comprehensive, full-color, clinically oriented text. Review the basic principles behind the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, and more. Use new imaging techniques to anatomically locate tumors before and during treatment. Apply multidisciplinary treatments with advice from experts in medical, surgical, and radiation oncology. Explore new treatment options such as proton therapy, which can facilitate precise tumor-targeting and reduce damage to healthy tissue and organs. Stay on the edge of technology with new chapters on IGRT, DNA damage and repair, and molecularly targeted therapies.

Radiobiology Self-Assessment Guide
Author : Jennifer Yu, MD, PhD,Mohamed Abazeed, MD, PhD
Publisher : Springer Publishing Company
Release Date : 2016-11-03
ISBN 10 : 1617052914
Pages : 520 pages

Radiobiology Self-Assessment Guide--a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide--is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute and Lerner Research Institute. Key Features: Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents

Head and Neck Cancer
Author : Dwight E. Heron, MD
Publisher : Demos Medical Publishing
Release Date : 2011-08-29
ISBN 10 : 1617050717
Pages : 152 pages

This issue of Radiation Medicine Rounds examines the latest advances in the use of radiation medicine in treatment of head and neck cancer. Head and neck cancer treatment has undergone major change over the course of the past few years and Head and Neck Cancer addresses current best practices in the light of the most recent evidence. Head and Neck Cancer addresses a wide range of topics under the broad heading of head and neck oncology. In the initial section, the authors address therapeutic approaches with chapters on current and future treatments. Coverage is extensive and includes articles on IMRT, combined modality treatments, the use of targeted agents in conjunction with chemotherapy, the use of transoral robotic surgery followed by postoperative radiation therapy, and the use of particle therapy. The second section addresses issues of health services and covers palliative care, how to assess toxicity in patients, and issues of interpreting and integrating classic study data into treatment decisions. The third section examines the factors influencing clinical decisions ranging including biomarkers and image guidance. . Radiation Medicine Rounds features : In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Each issue edited by an authority in that subject area Each issue focused on a single major topic in Radiation Medicine, providing coverage of advances in radiation science, radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcome studies Series Description: Radiation Medicine Rounds is a review series providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There will be an emphasis throughout on multidisciplinary approaches to the specialty, as well as an emphasis on quality and outcomes analysis. The goal is to provide authoritative, thorough assessment of a wide range of "hot topics" and emerging new data for the entire specialty of radiation medicine.

Multidisciplinary Management of Head and Neck Cancer
Author : Robert I. Haddad, MD
Publisher : Demos Medical Publishing
Release Date : 2010-11-23
ISBN 10 : 1617050121
Pages : 288 pages

Head and neck cancer is a very common cancer worldwide with an estimated 500,000 individuals diagnosed each year. In the United States an average of 39,000 new cases are reported each year representing between 3 to 5% of all new cancer cases diagnosed annually. Head and neck cancers are more common in men and in individuals over the age of 50. The treatment of head and neck cancer is extremely challenging and involves insight and expertise from multiple disciplines. Multidisciplinary Management of Head and Neck Cancer is a comprehensive textbook looking at different aspects of head and neck cancer, including the diagnosis, treatment and outcomes for patients with this disease. The chapters written by world-renowned experts cover the entire discipline of head and neck oncology and include discussion of the role of HPV infections, advances in radiotherapy, new surgical techniques, novel agents in thyroid therapy and more. The book is designed to be both practical and comprehensive for the physicians treating this complex disease. Features of Multidisciplinary Management of Head and Neck Cancer include: A chapter on the role of HPV infections in head and neck cancer A chapter on new advances in radiotherapy for head and neck cancer, including review IMRT, new standards and potential pitfalls Detailed discussion of the role of chemotherapy in head and neck cancer, including commonly used drugs and how to combine them with radiotherapy to improve patient outcomes Detailed discussion on incorporating novel agents with radiotherapy Detailed discussion of novel therapeutics in head and neck cancer, including new drugs and biologics

Clinical Radiation Oncology E-Book
Author : Leonard L. Gunderson,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release Date : 2011-09-16
ISBN 10 : 1455726036
Pages : 1660 pages

With thorough updates throughout, Clinical Radiation Oncology provides the most comprehensive, authoritative, and up-to-date information available for treating patients with cancer. From a multidisciplinary perspective, this new edition, edited by Drs. Leonard L. Gunderson and Joel E. Tepper, examines the therapeutic management of specific disease sites based on both single-modality and combined-modality approaches - providing you with the well-rounded, cutting-edge guidance you need to offer the most effective treatments. A consistent chapter format, full-color design, and access to the full text at make reference fast and easy. It is an ideal resource for mastering the latest, most effective techniques and modalities! Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors –many of whom are new to this edition – affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at, along with references, additional images and tables, video clips and more! Stay current with comprehensive updates throughout that include a new chapter on survivorship issues, and additional video clips on treatments such as prostate and penile cancer brachytherapy. Improve outcomes by providing the most effective treatment for each patient with expanded coverage of new modalities and treatment regimens. Understand and comply with the latest staging guidelines.

Otolaryngology--head and Neck Surgery
Author : Charles William Cummings
Publisher : Mosby Incorporated
Release Date : 1989
ISBN 10 :
Pages : 407 pages

Radiation Oncology E-Book
Author : James D. Cox,Kie Kian Ang
Publisher : Elsevier Health Sciences
Release Date : 2009-10-29
ISBN 10 : 0323076602
Pages : 1088 pages

Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference. Guides you through the use of the newest radiation oncology techniques, including principles of proton therapy and new developments in intensity-modulated radiotherapy (IMRT). Incorporates evidence from randomized clinical trials whenever possible to validate clinical recommendations. Presents full-color images throughout to match the images that you see in practice. Extensive use of "combination" imaging presents a complete picture of how to more precisely locate and target the radiotherapy field.

Abeloff's Clinical Oncology E-Book
Author : John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release Date : 2013-09-12
ISBN 10 : 1455728810
Pages : 2224 pages

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Contouring in Head and Neck Cancer
Author : Peter C. Levendag
Publisher : Elsevier,Urban&FischerVerlag
Release Date : 2009
ISBN 10 : 9783437599040
Pages : 254 pages

Introduction to the Cellular and Molecular Biology of Cancer
Author : Margaret Knowles,Peter Selby
Publisher : OUP Oxford
Release Date : 2005-07-28
ISBN 10 : 9780191513817
Pages : 554 pages

. What is cancer?, L.M. Franks and Margaret A. Knowles. 2. The causes of cancer, Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key. 3. Inherited Susceptibility to Cancer, D. Timothy Bishop. 4. DNA Repair and Cancer, Beate Koberle, John P. Wittschieben, and Richard D. Wood. 5. Epigenetic Events in Cancer, Jonathan C. Cheng and Peter A. Jones. 6. Molecular Cytogenetics of Cancer, Denise. Sheer and Janet Shipley. 7. Oncogenes, Margaret A. Knowles. 8. Tumour suppressor genes, Sonia Lain and David P. Lane. 9. The cancer cell cycle, Chris J. Norbury. 10. Cellular immortalization and telomerase activation in cancer, Robert F. Newbold. 11. Growth factors and their signalling pathways in cancer, Sally A. Prigent. 12. Apoptosis: molecular physiology and significance for cancer therapeutics, Dean A. Fennell. 13. Mechanisms of Viral Carcinogenesis, Paul Farrell. 14. Cytokines and Cancer, Peter W. Szlosarek and Frances R. Balkwill. 15. Hormones and cancer, Charlotte L. Bevan. 16. The spread of tumours, Ian Hart. 17. Angiogenesis, K.Tahtis and R.Bicknell. 18. Stem cells, heamopoiesis, and leukaemia, Mel Greaves. 19. Animal models of cancer, Jos Jonkers and Anton Berns. 20. The immunology of cancer, Peter C. L. Beverley. 21. The molecular pathology of cancer, Tatjana Crnogorac-Jurcevic, Richard Poulsom, and Nicholas R. Lemoine. 22. From transcriptome to proteome, Silvana Debernardi, Rachel Craven, Bryan D. Young, and Rosamonde E. Banks. 23. Local treatment of cancer, Ian S. Fentiman. 24. Chemotherapy, D.R. Camidge and D.I. Jodrell. 25. Radiotherapy and molecular radiotherapy, Anne Kiltie. 26. Monoclonal antibodies and therapy, T. Geldart, M.J. Glennie, and P.W.M. Johnson. 27. Immunotherapy of cancer, Andrew M. Jackson and Joanne Porte. 28. Cancer gene therapy, John David Chester. 29. Screening, Peter Sasieni and Jack Cuzick. 30. Conclusions and prospects, Peter Selby and Margaret A Knowles.

International Journal of Radiation Oncology, Biology, Physics
Author : N.A
Publisher : N.A
Release Date : 1986
ISBN 10 :
Pages : 329 pages

Radiation Therapy for Head and Neck Neoplasms
Author : Chiu-Chen Wang
Publisher : Year Book Medical Pub
Release Date : 1990
ISBN 10 :
Pages : 426 pages

Normal Tissue Reactions in Radiotherapy and Oncology
Author : Wolfgang Dörr,Wolfgang Dörr (Prof. Dr.),Rita Engenhart-Cabillic,Jörg S. Zimmermann
Publisher : Karger Medical and Scientific Publishers
Release Date : 2002
ISBN 10 : 3805572840
Pages : 206 pages

This volume covers all aspects of side effects in radio-oncological treatment of tumors, and of combined, multi-modal therapies. Recent developments as well as future perspectives in radiation biology of acute and late responding normal tissues are included. Special focus is given to more general treatment effects, such as anaemia, fatigue and impairment of quality of life, and post-treatment rehabilitation requirements. The book illuminates forensic aspects of radiation therapy and related complications; it further exemplifies incidence, documentation, and clinical management approaches for side effects as well as novel cyto-/tissue-protective strategies. Particular features of side effects after stereotactic or radiosurgical treatment of brain tumors, unconventional irradiation protocols for head and neck tumors, and conformal radiotherapy for prostate tumors are illustrated and followed by discussions of an optimization of physical treatment planning, e.g. by intensity modulation techniques. Bringing together medical, biological, molecular and physical expertise, research in the field of radiation-induced side effects is a true interdisciplinary effort. This publication will therefore be of great value to biologists, physicists and physicians of all disciplines involved in radio-oncological and multi-modal tumor therapy.

Management of Head and Neck Cancer
Author : Rodney R. Million,Nicholas J. Cassisi
Publisher : Lippincott Williams & Wilkins
Release Date : 1984
ISBN 10 :
Pages : 681 pages

Basic Science of Oncology, Fifth Edition
Author : Ian F. Tannock
Publisher : McGraw Hill Professional
Release Date : 2013-07-31
ISBN 10 : 0071745203
Pages : 575 pages

Basic Science of Oncology, 5e is an engaging state-of-art review of cancer causation, cancer biology, and the biology underlying cancer treatment. The fifth edition features critical updates in all areas of the fast-moving field of cancer care

Head and Neck Cancer, Volume III
Author : Jonas T. Johnson,Mukund S. Didolkar
Publisher : N.A
Release Date : 1993
ISBN 10 :
Pages : 997 pages

Aims to provide comprehensive coverage of head and neck cancer in a single volume. Topics examined include adjuvant chemotherapy, biologic modifiers and host responses, and molecular biologic aspects of the oncogenic process. Chemoprevention of the carcinogenetic process is also explored.

Squamous Cell Head and Neck Cancer
Author : David J. Adelstein
Publisher : Springer Science & Business Media
Release Date : 2007-11-06
ISBN 10 : 1592599389
Pages : 358 pages

Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.