Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
This unique book presents an up-to-date discussion of clinical disorders of the pituitary gland in children with specific emphasis on state-of-the-art diagnostic and treatment modalities, highlighting the newest scientific advances in genomics and molecular biology that clinician-scientists caring for children need to know. Chapters focus on the current knowledge base in genomics, pathophysiology, diagnosis, and medical and surgical management, organized into thematic sections. Part I discusses embryologic and genetic disorders, including genomics and congenital disorders of the pituitary. Part II presents acquired pituitary disorders, such as prolactinomas, Cushing's Disease, and both hormone secreting and non-secreting pituitary tumors. Subsequent sections cover posterior pituitary disorders, such as diabetes insipidus, functional hormone deficiencies of the hypothalamic-pituitary axis, including delayed puberty and pubertal disorders and growth hormone disorders, neuro-opthalmic disease, CNS radiation, childhood cancer treatment and traumatic brain injury. Authoritative and comprehensive, Pituitary Disorders of Childhood will serve as a precise guide for clinical endocrinologists and will guide future investigation into translational and clinical research on the pediatric pituitary.
Concise, Authoritative Answers on Every Aspect of Inpatient and Outpatient Care! Includes free access to CMDT online, a $79(U.S.) value! Now celebrating 45 years, CMDT delivers authoritative, timely coverage of more than 1,000 common diseases and disorders along with a clear synopsis of treatment and diagnosis. Utilizing a "find it now" format and made even more accessible by a detailed index, CMDT covers almost every aspect of general medicine with an emphasis on practical clinical diagnosis and patient management. Within its pages, readers will find a meticulous presentation of every major primary care topic, including: gynecology, ophthalmology, psychiatry, neurology, obstetrics, dermatology, otolaryngology, toxicology, and urology -- all from one of the world's most respected editorial boards.
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Provides detailed information on diagnostic radiology contributing to the broad field of imaging. Entries are written by leading experts and will provide basic and clinical scientists in academia, practice and industry with valuable information about the field of diagnostic imaging.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The #1 annual internal medicine guide that clinicians turn to first―extensively revised and updated CURRENT Medical Diagnosis & Treatment is the most comprehensive, reliable, and timely reference available to answer common questions that arise in everyday clinical practice. Written by clinicians renowned in their respective fields, this trusted classic offers expert advice on all aspects of outpatient and inpatient medical care. You’ll find authoritative, evidence-based coverage of more than 1,000 diseases and disorders including concise, yet thorough synopsis of diagnosis and treatment. Presented in full-color, this single source reference has been fully updated with the latest developments and breakthroughs in medicine, guidelines, references, drug prices, and more. This essential clinical companion features: • A strong emphasis on the practical aspects of clinical diagnosis and patient management • Detailed review of all internal medicine disciplines, including geriatrics, preventive medicine, and palliative care, plus gynecology and obstetrics, dermatology, ophthalmology, neurology, psychiatry, and more • An annual update on HIV/AIDS and other new, emerging viral infections • Specific information regarding disease prevention and prognosis • Medication treatment tables, with indexed trade names and updated prices • Key recent references on each topic with PMID numbers for quick online access • Many full-color photographs, tables, figures and other illustrations Here are some of the many updates and additions: • Extensive updating of tables and images • New FDA-approved medication for multiple sclerosis • New summary of recommended FDA treatment regimens for hepatitis C • U.S. Preventive Services Task Force recommendations for osteoporosis, prostate cancer, ovarian cancer, and cervical cancer • Extensive update of immune modulation therapy and adjuvant treatments of breast cancer • Targeted therapies for advanced non-small cell lung cancers • Thoroughly revised chapter on viral and rickettsial infections, including recent measles, polio, and acute flaccid paralysis outbreaks, and on related immunizations • Clarification of the appropriate role of opioids and buprenorphine formulations in chronic pain management • Revised section on health care for sexual and gender minority patients • Information on new biologic agents for asthma, and many other disorders
|Publisher||: Academic Press|
|Release Date||: 2019-02-15|
|ISBN 10||: 0128167246|
|Pages||: 300 pages|
G Protein Signaling Pathways in Health and Disease, Volume 161 in the Progress in Molecular Biology and Translational Science series, provides informative and exciting monographs on a wide variety of research topics related to G Protein Signaling Pathways in Health and Disease. The series gives in-depth knowledge on the important molecular biological aspects of organismal physiology and function, along with insights on how this knowledge can be applied to understand and ameliorate human disease. This updated release covers Diseases associated with mutations in CNGA3, Mutations in arrestins, Diseases caused by mutations in GPR101, Diseases caused by mutations in lutropin receptor, and much more. Comprises 15-20 chapters, providing substantial coverage on a given topic Contains ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided in each chapter Provides a comprehensive guide to the latest information available on prions, viruses, bacteria, and eukaryotes
This book presents, in a stepwise and interactive fashion, approximately 75 cases that reflect the wide spectrum of pathology encountered in this region. Each case description commences with a concise clinical scenario. High-quality radiologic, laboratory, and histopathologic images depicting the differentiating features of the lesion subtype in question are then presented, and key operative and clinical management pearls are briefly reviewed. The interdisciplinary nature of this easy-to-use color atlas and textbook reflects the fact that the management of patients with sellar and parasellar lesions is itself often interdisciplinary. The format is unique in that no similar interdisciplinary book is available on lesions of this region of the brain. Atlas of Sellar and Parasellar Lesions: Clinical, Imaging, and Pathologic Correlations is of great value for practitioners and trainees in a range of medical specialties, including radiology, neurology, endocriniology, pathology, oncology, radiation oncology, and neurosurgery.
The World Health Organization estimated that each year there are more than 13 million deaths caused by environmental causes. Exposure to endocrine disrupting chemicals (EDCs) during development may cause long-term health outcomes. This book, Endocrine Disruptors, includes eight chapters that illustrate potential endocrine-disrupting activities in water, sediments, crops, animals, and humans. This book assesses the relationship between the EDCs and development, reproduction, or obesity. Finally, detection of the levels of EDCs by autobioluminescent cellular bioreporters is discussed. Scientists, physicians, neuroendocrinologists, neurotoxicologists, and lay readers who have engaged in EDC studies or practice will discover that this book offers insight into all areas of EDC research.
The second edition of the Atlas of Cancer highlights the major features of current cancer management, and clearly presents fundamental facts regarding our understanding of the etiology and pathophysiology of malignant disease.
|Author||: Thomas H. Ollendick,Carolyn S. Schroeder|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2003-07-31|
|ISBN 10||: 9780306474903|
|Pages||: 748 pages|
One volume-reference work with approximately 300 entries Each entry will contain 5-8 references Entries will kept under 7 pages, with limited references and cross-referenced to 5 other topics in the encyclopdia
The manuscripts in this volume were contributed by the speakers invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The meeting was organized to commemorate the description of acromegaly by the French physician Pierre Marie, in 1886. The members of the Scientific Committee spent many hours assisting us in ensuring an outstanding meeting. The support of Serono Symposia, USA in all phases of the planning and execution of the meeting was sincerely appreciated and was highly professional. Special recognition roust be extended to Professor Roger Guillemin of the Salk Institute, whosp interest in medical history led him to devote a great deal of time and personal expense in obtaining information about the life of Pierre Marie. Dr. GuilIemin's presentation on the life and times of Marie was an extraordinary overview of the cultural, social, and scientific backgrounds in which Marie came to describe the disease, acromegaly. Dr. Guillemin' s findings, which were presented at the main banquet in a splendid audiovisual presentation, were clearly the highlight of the meeting and will long be remembered by the attendees. We were also honored by the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her address at the banquet, Dr. Granier provided several delightful and intimate vignettes concerning Pierre Marie, using old family records and photographs. The Scientific Committee wishes to extend its gratitude to Dr. Granier for adding immeasurably to the historical atmosphere of the meeting.
A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.
|Author||: Woods Hutchinson|
|Release Date||: 1900|
|Pages||: 109 pages|
In Loving Large, Patti M. Hall confronts gigantism, an ultra-rare, infamous, and stigmatizing disease that threatens her young son’s life and future. With wit, candour, and hilarity, she endures the harrowing medical odyssey with her two sons and learns to thrive in the aftermath.
“A very funny [memoir] about the frailties of the flesh, the absurdities of modern medicine, and how to stay sane amid it all” (Dave Eggers). Raucous family memoir meets medical adventure in this “winning literary debut” that explores the public and private theaters of illness (The New York Times Book Review). After a pituitary tumor bursts in Mike Scalise’s brain (diagnosed, by of all people a physician named Dr. Sunshine), it leaves him with a hole in head, and the hormone disorder acromegaly at age twenty-four. He also faces the exasperating challenge of navigating a new, alien world of illness maintenance among family, friends, and spouse. However, it’s his mother, who has a chronic heart condition and a flair for drama, who becomes a complicated model as she competes with her son for the status of “best sick person.” “Captur[ing] all the fright of a medical calamity and the humor and grace necessary to survive it (Kirkus Reviews), “Mike Scalise’s startling and slyly hilarious memoir is a heartfelt reminder of how astonishing, how terrifying, how absurd it is to be a body. An essential book for those who’ve lived through catastrophe, or only imagined it” (Alexandra Kleeman, author of You Too Can Have a Body Like Mine).