Exercise and Sports Epigenetics: Concepts, Methods, and Current Research explains fundamental epigenetic processes and how these are altered by exercise and sports. After a brief review of fundamental epigenetic biology, this all-new volume in the Translational Epigenetics series offers step-by-step instruction in how epigenetic factors are investigated for their influence over exercise related traits of human physiology, disease, and injury. The current state of knowledge in the field and recent findings are discussed in-depth, illuminating how exercise and sports performance may epigenetically modify our physiology, disease and injury risks, and how this knowledge can be applied in personalized exercise approaches, diagnostics, and treatment. This book also explores the shortcomings of explaining exercise related phenomena using only genomics and traditional biochemical techniques, setting the scene for a paradigm shift in exercise biology. In addition, over a dozen international specialists contribute chapters on exercise and sports epigenetics, and their influence over metabolism, obesity, aging, immunity, and neurological disease, as well as the epigenetic impacts of concussions and sports doping. A concluding chapter discusses ongoing themes in the field and outlooks for future research. Thoroughly examines fundamental concepts in exercise and sports epigenetics, methods for new research, and known impacts for human physiology, disease, and clinical outcomes Discusses exercise and sports epigenetics in relation to metabolism, obesity, aging, immunity, and neurological disease, concussion, and sports doping, among other topics Features chapter contributions from international experts in the field
Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions is the first reference volume to offer a holistic examination of omics-driven advances across different aspects of exercise and sports physiology, biochemistry, sports medicine, psychology, anthropology, and sports nutrition; and highlighting the opportunities towards advance personalized training and athlete health management. More than 70 international experts from 14 countries have discussed key exercise and sport-related themes through the prism of genomics, epigenomics, transcriptomics, proteomics, metabolomics, telomere biology, talent in sport, individual differences in response to regular physical activity, that in the future may empower coaches, sports physicians, fitness experts, genetic counselors, and translational scientists to employ various omics data and approaches in improving health and physical performance of people participating in sports and exercise activities. Contributors address current knowledge of genetic influence on athletic performance, individual responses to exercise training, as well as the genetics of musculoskeletal phenotypes, exercise-related injuries, flexibility, and neurodegenerative disorders in athletes. Finally, performance-related and psychological traits associated with epigenetic, transcriptomic and metagenomic biomarkers are also considered, along with nutritional and pharmacogenomic aids in sports medicine and personalized nutrition. Effectively synthesizes key themes across molecular aspects of exercise and sports sciences Provides a knowledge base for future translation of omics solutions to talent identification, individualized training, and nutrition Features contributions from international experts (researchers and clinicians) in the subject area
|Author||: J. Timothy Lightfoot,Monica J. Hubal,Stephen M. Roth|
|Release Date||: 2019-03-14|
|ISBN 10||: 1351380168|
|Pages||: 514 pages|
Technological advances over the last two decades have placed genetic research at the forefront of sport and exercise science. It provides potential answers to some of contemporary sport and exercise’s defining issues and throws up some of the area’s most challenging ethical questions, but to date, it has rested on a fragmented and disparate literature base. The Routledge Handbook of Sport and Exercise Systems Genetics constitutes the most authoritative and comprehensive reference in this critical area of study, consolidating knowledge and providing a framework for interpreting future research findings. Taking an approach which covers single gene variations, through genomics, epigenetics, and proteomics, to environmental and dietary influences on genetic mechanisms, the book is divided into seven sections. It examines state-of-the-art genetic methods, applies its approach to physical activity, exercise endurance, muscle strength, and sports performance, and discusses the ethical considerations associated with genetic research in sport and exercise. Made up of contributions from some of the world’s leading sport and exercise scientists and including chapters on important topical issues such as gene doping, gender testing, predicting sport performance and injury risk, and using genetic information to inform physical activity and health debates, the handbook is a vital addition to the sport and exercise literature. It is an important reference for any upper-level student, researcher, or practitioner working in the genetics of sport and exercise or exercise physiology, and crucial reading for any social scientist interested in the ethics of sport.
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine
In the past century, nearly all of the biological sciences have been directly affected by discoveries and developments in genetics, a fast-evolving subject with important theoretical dimensions. In this rich and accessible book, Paul Griffiths and Karola Stotz show how the concept of the gene has evolved and diversified across the many fields that make up modern biology. By examining the molecular biology of the 'environment', they situate genetics in the developmental biology of whole organisms, and reveal how the molecular biosciences have undermined the nature/nurture distinction. Their discussion gives full weight to the revolutionary impacts of molecular biology, while rejecting 'genocentrism' and 'reductionism', and brings the topic right up to date with the philosophical implications of the most recent developments in genetics. Their book will be invaluable for those studying the philosophy of biology, genetics and other life sciences.
|Author||: Italia Di Liegro|
|Release Date||: 2020-05-12|
|ISBN 10||: 3039284800|
|Pages||: 170 pages|
From an evolutionary perspective, our species has relied upon physical activity for most of its history to survive and has had to escape from predators, to scavenge for food, and to use physique to work or build necessary means for everyday life. Physical activity has been part of our evolution and progress since the very beginning and, consequently, our entire body has been programmed to be active physically. In the last 20 years, scientific research has increasingly shown that our ancient survival principle has beneficial effects not only on the cells and organs involved in physical activities but on the metabolism of the entire organism, influencing the homeostasis and integration of all bodily functions, likely stimulating the production of hormones and other regulatory molecules, with each affecting vital signalling pathways. Most of the web of factors involved in molecular signalling upon exercise are suspected to be centrally controlled by the brain, which has been reported to be deeply modified by physical activity. Such complexity requires a multifaceted approach to shed light on the molecular interactions that occur between physical activity and its outcome at a cellular level.
Physical activity is vital for good health. It has an established strong evidence base for its positive effects on functional capacity, reducing the risk of many chronic diseases, and promoting physical, mental and social well-being. Furthermore, these benefits are evident across a diversity of ages, groups and populations. The need for these benefits in current societies means that exercise practitioners, professional bodies, institutions, health authorities and governments require high quality evidence to establish appropriate exercise guidelines, implementation strategies and effective exercise prescription at individual, group and population levels. Research Methods in Physical Activity and Health is the first book to comprehensively present the issues associated with physical activity and health research and outline methods available along with considerations of the issues associated with these methods and working with particular groups. The book outlines the historical and scientific context of physical activity and health research before working through the full research process, from generating literature reviews and devising a research proposal, through selecting a research methodology and quantifying physical activity and outcome measures, to disseminating findings. Including a full section on conducting research studies with special populations, the book includes chapters on: Observational and cross-sectional studies; Interviews, questionnaires and focus groups; Qualitative and quantitative research methods; Epidemiological research methods; Physical activity interventions and sedentary behaviour; and Working with children, older people, indigenous groups, LGBTI groups, and those with physical and mental health issues. Research Methods in Physical Activity and Health is the only book to approach the full range of physical activity research methods from a health perspective. It is essential reading for any undergraduate student conducting a research project or taking applied research modules in physical activity and health, graduate students of epidemiology, public health, exercise psychology or exercise physiology with a physical activity and health focus, or practicing researchers in the area.
Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies
The New York Times bestseller – with a new afterword about early specialization in youth sports – by the author of Range: Why Generalists Triumph in a Specialized World. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration of athletic success and the so-called 10,000-hour rule, David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving it. Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.
Explores the Newly Discovered Link Between Nutrition and EpigeneticsCurrent research suggests that nutrients are more than just food components and that certain nutrients can impact the expression of genes that lead to the development of chronic diseases. With contributions from experts in both fields, Nutrients and Epigenetics examines the epigene
Sports, Society, and Technology: Bodies, Practices, and Knowledge Production addresses the complex entanglements of science, technology, and sporting cultures. The collection explores themes around human and non-human actants, knowledge formations and processes, and the materiality and multiplicity of bodies through an engagement with the interdisciplinary fields of Sport Studies and Science and Technology Studies. Representing a range of methodological, theoretical, and disciplinary approaches, contributors interrogate the social, cultural, political, and historical intersections of an ever-expanding techno-scientific sporting landscape – from true bounce and brain trauma to exercise physiology, metrics, and esports, and from feminist technoscience, whey protein, and epigenetics to sickle cell screening and testosterone regulation.
Physiology of Sport and Exercise, Seventh Edition With Web Study Guide, continues its legacy as a top physiology textbook and favorite of instructors and students alike. Combining research with extensive visual aids, this resource offers a simple way for students to develop an understanding of the body’s abilities to perform various types and intensities of exercise and sport, to adapt to stressful situations, and to improve its physiological capacities. Written by a team of distinguished researchers, all past presidents of the American College of Sports Medicine, this seventh edition has been updated based on the most recent position stands, standards, and guidelines in the field of sport and exercise physiology. Throughout the text, updated photos join with the superb illustrations and medical artwork to clarify difficult concepts and illustrate how the body performs. Digital components found in the web study guide now include 26 animations that offer a dynamic way to experience physiological concepts, and 66 audio clips that provide explanations of complex physiological processes to aid students’ understanding of important illustrations in the text. Leaders in the field discuss recent developments and real-world applications in 27 video clips to help students connect theoretical and practical concepts. Corresponding icons throughout the text notify students when digital elements are available to complement the materials. In addition to the expanded digital components, Physiology of Sport and Exercise, Seventh Edition, features new and updated content based on the latest research in the field: Additional information on overtraining and exercise addiction Expanded content on fatigue and mobility in aging New sections on epigenetics, bioinformatics, and neuromuscular function New information on exercise genomics New Research Perspectives emphasizing emerging findings in the field, and a new Research Perspectives Finder to help students locate key content quickly Ease of reading has been the standout feature of this popular text. The seventh edition continues to offer comprehensive coverage of the complex relationship between human physiology and exercise while maintaining an engaging and student-friendly tone. Unique learning features paired with an accessible layout, including chapter-opening outlines and review boxes throughout each chapter, will help students focus on the major concepts addressed. Study questions and a list of key terms at the end of the chapter increase students’ opportunities for recall and self-testing. A comprehensive glossary and lists of common abbreviations and conversions provide easy reference for students as they complete labs and assignments. To foster an enriched learning experience, both students and instructors can take advantage of the web-based ancillaries that accompany the text. In addition to animations, videos, and audio clips, the web study guide includes comprehension quizzes to provide immediate feedback to students on their knowledge retention as well as end-of-unit mastery checks that students can use for evaluating their progress. Instructors are provided with access to an instructor guide, test package, ready-to-use chapter quizzes, and a presentation package plus image bank. The presentation package includes PowerPoint slides with key points and content, which can be modified to suit a variety of class structures. An image bank features all of the graphics, artwork, and content photos from the text for easy insertion into tests, quizzes, handouts, and other course materials. Digital extras—composed of the animations, videos, and audio clips that students find in the web study guide—bolster comprehension of challenging concepts. Physiology of Sport and Exercise has been a pivotal textbook of the engaging field of exercise physiology. Through dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content enriched with visual supplements, students and instructors will find this an invaluable resource for their continued education.