This is the first and only book, so far, to deal with the causal basis of evolution from an epigenetic view. By revealing the epigenetic "user" of the "genetic toolkit", this book demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theory with a host of examples from the most varied fields of biology, by emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. Original and thought provoking--a radically new theory that overcomes the present difficulties of the theory of evolution Is the first and only theory that uses epigenetic mechanisms and principles for explaining evolution of metazoans Takes an integrative approach and shows a wide range of learning
Epigenetic Principles of Evolution, Second Edition, fully examines the causal basis of evolution from an epigenetic point-of-view. By revealing the epigenetic uses of the genetic toolkit, this work demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theoretical perspective with examples from varied fields of biology, emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. Users will find a broader view of the epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic structures, such as DNA methylation, histone modifications, and patterns of miRNA, sRNA, and mRNA expression. This second edition is thoroughly updated to reflect new evidence and developing theories in the field of evolutionary epigenetics. New and revised chapters speak to the epigenetic basis of heredity, epigenetic regulation of animal structure and homeostasis, neural manipulation of gene expression, central control of gametogenesis, epigenetic control of early development, the origin of epigenetic information, evolutionary changes in response to environmental stressors, epigenetics of sympatric evolution, and the epigenetics of the Cambrian explosion, among other topics. Adopts an integrative approach to examine the causal basis of evolution from an epigenetic point-of-view Features new and revised chapters which reflect novel experimental and observational evidence in the field of evolutionary epigenetics, as well as alternative theoretical approaches Offers a broad view of epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic mechanisms, such as DNA methylation, histone modifications, and patterns of miRNA, sRNA and mRNA expression
Building the Most Complex Structure on Earth provides readers with a basic biological education an easy and understandable introduction into a new epigenetic theory of development and evolution. This is a novel theory that describes the epigenetic mechanisms of the development and evolution of animals and explains the colossal evolution and diversification of animals from a new post-genetic perspective. Modern biology has demonstrated the existence of a common genetic toolkit in the animal kingdom, but neither the number of genes nor the evolution of new genes is responsible for the development and evolution of animals. The failure to understand how the same genetic toolkit is used to produce millions of widely different animal forms remains a perplexing conundrum in modern biology. The novel theory shows that the development and evolution of the animal kingdom are functions of epigenetic mechanisms, which are the competent users of the genetic toolkit. Provides a comprehensive view of the epigenetic aspects of reproduction, development, and evolution. Highly rigorous, but simple enough for readers with only a basic knowledge of biology.
Epigenetic Mechanisms of the Cambrian Explosion provides readers with a basic biological knowledge and epigenetic explanation of the biological puzzle of the Cambrian explosion, the unprecedented rapid diversification of animals that began 542 million years ago. During an evolutionarily instant of 10 million years, which represents only 0.3% of the time of existence of life on Earth, or less than 2% of the time of existence of metazoans, all of the 30 extant body plans, major animal groups (phyla) and several extinct groups appeared. The work helps address this phenomena and tries to answer remaining questions for evolutionary biology, epigenetics, and scientific researchers. The book recognizes and presents objective representations of alternative theories for epigenetic evolution in this period, with the author drawing on his epigenetic theory of evolution to explain the causal basis of the Cambrian explosion. Both empirical evidence and theoretical arguments are presented in support of this thought-provoking epigenetic theory. Explains the Cambrian explosion from an entirely epigenetic view Takes a causal rather than descriptive approach to the phenomenon Allows for a broad readership, including those with only a basic biological knowledge, while maintaining scientific rigor
Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.
"Epigenetic Principles of Evolution is a postgenetic treatment of the problem of metazoan evolution. It presents a radically novel epigenetic theory of evolution describing epigenetic mechanisms of evolutionary changes as they arise in the process of individual development. In seven chapters of Part 1 (Epigenetic Basis of Metazoan Heredity, pp. 21-216) the author introduces the reader to the epigenetic system of heredity - a function of the integrated control system. Cabej describes the dominant role of the epigenetic system of heredity in the processes of reproductive functions (chapter 3), in gametogenesis and in the process of the deposition of parental cytoplasmic factors (=epigenetic information) in gametes (chapter 4). In chapter 5 the author shows how the epigenetic information deposited in gametes in the form of maternal cytoplasmic factors determines the early embryonic development from the zygote stage to the phylotypic stage. A detailed description of the control of the postphylotypic stage of development, especially the formation of organs and organ systems, is presented in chapter 6 (p. 139-202). An outline of the main features of the epigenetic system of heredity and its relationship with the genetic system of heredity is provided in chapter 7 (203-216). Interactions between metazoan organisms and their environment, metazoan responses (especially behavioral responses) to changes in the environment and the ontogeny as a workshop of evolutionary change are dealt with in three chapters (8-10) of Part 2 (Neural-developmental premises of evolutionary adaptation, pp. 219-281). In Part 3 (chapters 11 and 12, pp. 285-339) the author deals with the mechanisms of developmental plasticity, the so-called circumevolutionary phenomena, and reveals the essential similarity between the transgenerational developmental plasticity and evolutionary change. In Part 4, Epigenetics of Metazoan Evolution (p. 341-623), the author deals in details with evolution of the control system (chapter 13, pp. 341-377), developmental mechanisms of evolutionary change in evolutionary modifications (chapter 14, pp. 379-501), evolution by loss/vestigialization of organs (chapter 15, pp. 501-541), evolution by reverting to ancestral structures (chapter 16, pp. 543-569). A special chapter is devoted to the role of the neural crest, a uniquely vertebrate structure of neural origin, in evolution of de novo metazoan structures. Evolutionary convergences and their evolutionary-epigenetic implications are discussed in chapter 18. Part 5 (p.645-732) is devoted to description of epigenetic mechanisms as determinants of species formation in sympatry. For all the cases of evolution of structures and species formation described in the book, the author presents both the conventional neoDarwinian explanation and the epigenetic explanation making it possible for the reader to assess the relative explanatory power of the genetic and epigenetic explanations. The book was published in 2008 by Albanet Publishing and contains 880 pages."--Amazon.
A pioneering proposal for a pluralistic extension of evolutionary theory, now updated to reflect the most recent research.
Principles of Evolution covers all aspects of the subject. Following an introductory section that provides necessary background, it has chapters on the evidence for evolution that cover the fossil record, DNA-sequence homologies, and protein homologies (evo-devo). It also includes a full history of life from the first universal common ancestor, through the rise of the eukaryote and on to the major groups of phyla. This section is followed by one on the mechanism of evolution with chapters on variation, selection and speciation. The main part of the book ends with a chapter on human evolution and this is followed by appendices that expand on the making of fossils, the history of the subject and creationism. What marks this book as different from others on evolution is its systems-biology perspective. This new area focuses on the role of protein networks and on multi-level complexity, and is used in three contexts. First, most biological activity is driven by such networks and this has direct implications for understanding evo-devo and for seeing how variation is initiated, mainly during embryogenesis. Second, it provides the natural language for discussing phylogenetics. Third, evolutionary change involves events at levels ranging from the genome to the ecosystem and systems biology provides a context for integrating material of this complexity. The book assumes a basic grounding in biology but little mathematics as the difficult subject of evolutionary population genetics is mainly covered qualitatively, with major results being discussed and used rather than derived. Principles of Evolution will be an interesting and thought-provoking text for undergraduates and graduates across the biological sciences.
Evolutionary science is critical to an understanding of integrated human biology and is increasingly recognised as a core discipline by medical and public health professionals. Advances in the field of genomics, epigenetics, developmental biology, and epidemiology have led to the growing realisation that incorporating evolutionary thinking is essential for medicine to achieve its full potential. This revised and updated second edition of the first comprehensive textbook of evolutionary medicine explains the principles of evolutionary biology from a medical perspective and focuses on how medicine and public health might utilise evolutionary thinking. It is written to be accessible to a broad range of readers, whether or not they have had formal exposure to evolutionary science. The general structure of the second edition remains unchanged, with the initial six chapters providing a summary of the evolutionary theory relevant to understanding human health and disease, using examples specifically relevant to medicine. The second part of the book describes the application of evolutionary principles to understanding particular aspects of human medicine: in addition to updated chapters on reproduction, metabolism, and behaviour, there is an expanded chapter on our coexistence with micro-organisms and an entirely new chapter on cancer. The two parts are bridged by a chapter that details pathways by which evolutionary processes affect disease risk and symptoms, and how hypotheses in evolutionary medicine can be tested. The final two chapters of the volume are considerably expanded; they illustrate the application of evolutionary biology to medicine and public health, and consider the ethical and societal issues of an evolutionary perspective. A number of new clinical examples and historical illustrations are included. This second edition of a novel and popular textbook provides an updated resource for doctors and other health professionals, medical students and biomedical scientists, as well as anthropologists interested in human health, to gain a better understanding of the evolutionary processes underlying human health and disease.
Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies
This book discusses the evidence for and against the heritability of acquired characters. Since it presents original and controversial arguments about the importance of epigenetic inheritance, this work provides a basis for discussion, modelling, and experimental investigation of the role of environmentally induced variation in evolution. Of interest to a broad range of biologists and other scientists. With a new Preface describing the impact of the hardback editionon subsequent research and a new Appendix of selected publications influenced by the book.