energy metabolism in heart failure

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Cardiac Energy Metabolism in Health and Disease
Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Release Date : 2014-08-22
ISBN 10 : 1493912275
Pages : 295 pages
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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release Date : 2019-08-08
ISBN 10 : 2889459381
Pages : 89 pages
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The Scientist's Guide to Cardiac Metabolism
Author : Michael Schwarzer,Torsten Doenst
Publisher : Academic Press
Release Date : 2015-11-04
ISBN 10 : 0128026146
Pages : 240 pages
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The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release Date : 2019-08-08
ISBN 10 : 2889459381
Pages : 89 pages
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ATP and the Heart
Author : Joanne S. Ingwall
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
ISBN 10 : 1461510937
Pages : 244 pages
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ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.

Mitochondrial Diseases
Author : Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publisher : BoD – Books on Demand
Release Date : 2018-08-29
ISBN 10 : 1789236746
Pages : 496 pages
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Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Heart Failure: A Companion to Braunwald's Heart Disease E-book
Author : Douglas L. Mann
Publisher : Elsevier Health Sciences
Release Date : 2010-11-11
ISBN 10 : 1437703631
Pages : 928 pages
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Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care

Myocardial Energy Metabolism
Author : J.W. de Jong
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
ISBN 10 : 9400913192
Pages : 310 pages
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The Failing Heart
Author : Naranjan S. Dhalla
Publisher : Raven Press
Release Date : 1995
ISBN 10 :
Pages : 524 pages
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(Proc./Intl Conf. 5/94) Topics inc. atrial defibrillation & congestive heart failure trmt of symptomatic heart failure.

Cardiac Metabolism in Health and Disease
Author : Salah Abdel-aleem,James E. Lowe
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
ISBN 10 : 1461556872
Pages : 202 pages
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This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews focused in the field of cardiac metabolism and its regulation under normal and disease conditions. These papers cover many areas under intensive and rapid development such as the regulation of fatty acid oxidation in the heart, the role of cardiac glycogen during ischemia, the role of CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy, cardiac protection through regulation of energy production, the role of fatty acid binding protein under normal and pathological conditions, and several other important topics in this area of research. We hope that this special issue of Molecular and Cellular Biochemistry provides an up-to-date source of information for scientists and clinicians interested in the mechanism by which cardiac metabolism is regulated in health and disease and the mechanistic relationship between disturbances in cardiac metabolism and the genesis of cardiovascular diseases.

Post-Genomic Cardiology
Author : José Marín-García
Publisher : Academic Press
Release Date : 2011-04-28
ISBN 10 : 9780080554549
Pages : 688 pages
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Recent advances in molecular and cellular biology have markedly changed our understanding of the heart, and this is having tremendous ramifications for the clinician. This unique reference offers a comprehensive and critical evaluation of this contribution in the field of cardiovascular molecular medicine providing the reader with a sense of new directions in which molecular medicine might be applied. It begins with a detailed primer that makes readily accessible recent molecular, genetic and cellular techniques. Rounding out the coverage of this exciting field are critical and comprenhesive discussions on the use of molecular, genetic and cellular techniques used to identify the etiology and pathophysiology of specific cardiac diseases. * Discusses diagnostic and therapeutic options available not only in the adult and aging individuals but also in infants/children * Numerous illustrations and flow-charts * Explans cutting-edge molecular techniques, including analysis of mitochondria, their role in cardiac dysfunction and updated analysis of Cardioprotection and Metabolic Syndrome * Presentation of recent translational studies for the treatment of cardiovascular diseases is included (e.g., gene therapy, pharmacological treatments and stem cell transplantation)

The Sinatra Solution
Author : Stephen T. Sinatra
Publisher : Basic Health Publications, Inc.
Release Date : 2007-10
ISBN 10 : 9781591202165
Pages : 253 pages
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A board-certified cardiologist discusses the importance of energy metabolism on cardiovascular health and the positive impact three energy-supplying nutrients--CoQ10, Carnitine, and Ribose--have on the cardiovascular system.

Cellular and Molecular Pathobiology of Cardiovascular Disease
Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Release Date : 2013-12-23
ISBN 10 : 0124055257
Pages : 338 pages
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Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Acute Heart Failure
Author : Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo
Publisher : Springer Science & Business Media
Release Date : 2009-12-24
ISBN 10 : 9781846287824
Pages : 931 pages
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For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.

Oxford Textbook of Heart Failure
Author : Theresa A. McDonagh,Roy S. Gardner,Andrew L. Clark,Henry Dargie
Publisher : Oxford University Press
Release Date : 2011-07-14
ISBN 10 : 0199577722
Pages : 641 pages
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The Oxford Textbook of Heart Failure takes the reader from an understanding of the basic mechanisms of heart failure, through to an appreciation of the complexities of heart failure management and the improvements possible with good treatment. Written by internationally renowned leaders in the field, this definitive textbook comprehensively covers all aspects necessary to manage a patient with heart failure, and is essential reading for consultant cardiologists, those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses. The online version of the Oxford Textbook of Heart Failure contains the full text of the print edition (which can be browsed by the contents list or searched), links from references in the text to external sources (via PubMed, ISI, and CrossRef), and over 300 figures and illustrations from the print edition, downloadable into PowerPoint.

Heart Failure: A Companion to Braunwald's Heart Disease E-Book
Author : G. Michael Felker,Douglas L. Mann
Publisher : Elsevier Health Sciences
Release Date : 2019-02-06
ISBN 10 : 0323609880
Pages : 784 pages
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Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment
Author : Scott D Mendelson
Publisher : Academic Press
Release Date : 2007-12-19
ISBN 10 : 9780080556529
Pages : 224 pages
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Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

Metabolism and Nutrition for the Surgical Patient, Part II, An Issue of Surgical Clinics - E-Book
Author : Stanley Dudrick
Publisher : Elsevier Health Sciences
Release Date : 2011-08-28
ISBN 10 : 145570928X
Pages : 272 pages
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This Surgical Clinics issue is Part 2 of a special two part issue on nutrition and metabolism of the surgical patient, co-guest edited by Dr. Stanley Dudrick, a pioneer in total parenteral nutrition. Part 2, guest edited by Dr. Dudrick and Dr. Juan Sanchez present topics on nutrition and metabolism for the chronically ill patient. Topics will include: nutrition management of acute and chronic pancreatitis, surgical treatment of patients with diabetes mellitus, nutrition management of geriatric surgical patients, nutrients, routes of delivery and immunocompetence, immunologic functions and aspects of the alimentary tract related to feeding, overview of enteral and parenteral feeding access techniques, dietary, metabolic and surgical management of obese patients, historical highlights of the development of total parenteral nutrition, nutrition support of patients with cardiovascular disease, genomic and epigenomic aspects of nutrition and metabolism in surgical patients, nutrition support of patients with inflammatory bowel disorders of the small intestine, colon and rectum, nutrition support of patients with cancer, home parenteral nutrition for intestinal failure, and more.

Biophysics of the Failing Heart
Author : R. John Solaro,Jil C. Tardiff
Publisher : Springer Science & Business Media
Release Date : 2013-08-13
ISBN 10 : 146147678X
Pages : 253 pages
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Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

Heart Failure
Author : José Marín-García
Publisher : Springer Science & Business Media
Release Date : 2010-06-23
ISBN 10 : 1607611473
Pages : 470 pages
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Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.