The rise in the incidence of health problems such as reproductive disorders and testicular and breast cancer has been linked by some to endocrine disrupting chemicals in the environment. The role of food in transmitting these chemicals is uncertain and a topic of considerable research. This important book addresses key topics in this area. The first part of the book reviews the impacts of endocrine disrupting chemicals on health and behaviour, with chapters on the effect of dietary endocrine disruptors in such areas as the developing foetus, cancer and bone health. Parts two and three focus on the origin and analysis of endocrine disruptors in food products and risk assessment. Topics addressed include surveillance, analysis techniques such as biosensors, exposure assessment and the relevance of genetics, epigenetics and genomic technologies to the study of endocrine disrupting chemicals. Concluding chapters discuss examples of selected endocrine disrupting chemicals associated with food, such as dioxins, polychlorinated biphenyls and brominated flame retardants, bisphenol A and phytoestrogens and phytosterols. With its distinguished editor and international team of contributors, Endocrine-disrupting chemicals in food is an essential reference for all those concerned with ensuring the safety of food. Reviews the impacts of endocrine disrupting chemicals on health and behaviour including cancer and reproductive disorders Addresses the origin and analysis of endocrine disruptors with chapters on surveillance and analysis techniques Examines the relevance of genetics, epigenetics and genomic technologies to endocrine disrupting chemicals
Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
|Author||: Leo M. L. Nollet|
|Publisher||: John Wiley & Sons|
|Release Date||: 2011-06-09|
|ISBN 10||: 0470961848|
|Pages||: 504 pages|
Analysis of Endocrine Disrupting Compounds in Food provides a unique and comprehensive professional reference source covering most of the recent analytical methodology of endocrine disrupting compounds in food. Editor Nollet and his broad team of international contributors address the most recent advances in analysis of endocrine disrupting chemicals in food. While covering conventional (typically lab-based) methods of analysis, the book focuses on leading-edge technologies that recently have been introduced. The book looks at areas such as food quality assurance and safety. Issues such as persistent organic pollutants, monitoring pesticide and herbicide residues in food, determining heavy and other metals in food and discussing the impacts of dioxins, PCBs, PCDFs and many other suspected chemicals are covered. The book discusses the relationship between chemical compounds and hormone activity. What are the health impacts of different chemical compounds for men and animals? How are these compounds entering in foodstuffs? Analysis of Endocrine Disrupting Compounds in Food offers the food professional what its title promises – a compendium of sample preparation and analysis techniques of possible endocrine disrupting compounds in food. Special Features: Uniquely concentrates on analysis and detection methods of EDCs in foodstuffs Extensive coverage of the main types of globally available analytical techniques and methodologies Fully detailed properties, sample procedures, and analysis steps for each EDC Renowned editor Leo Nollet leads a broad team of international experts
A concise and engaging overview of endocrine disruptionphenomena that brings complex concepts within the reach ofnon-specialists For most of the last decade, the science of endocrine disruptionhas evolved with more definitive evidence of its damaging potentialto health and environment. This book lists the major environmentalchemicals of concern and their mechanism of endocrine disruptionincluding remedial measures for them. Divided into three parts, Endocrine Disruptors in theEnvironment begins with an overview of the endocrine system andendocrine disruptors, discussing their salient features andpresenting a historical perspective of endocrine disruptionphenomena. It then goes on to cover hormone-signaling mechanisms,followed by various broad classes of putative endocrine disruptors,before introducing readers to environmental epigeneticmodifications. Part two of the book focuses on removal processes ofvarious EDCs by biotic and abiotic transformation/degradation. Thelast section consists of four chapters embracing themes on findingsolutions to environmental EDCs—including their detection,regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first bookto detail the endocrine effects of several known environmentalcontaminants and their mechanism of endocrine disruption.Additionally, it: Covers both the chemistry and biology of endocrine disruptionand compiles almost all the known endocrine disruptingenvironmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCsincluding scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoidingendocrine disruption in the designing and screening for saferchemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list ofacronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal bookfor environmental chemists and endocrine toxicologists,developmental biologists, endocrinologists, epidemiologists,environmental health scientists and advocates, and regulatoryofficials tasked with risk assessment in environment and healthareas.
|Author||: Alberto Mantovani,Alexandra Fucic|
|Publisher||: Royal Society of Chemistry|
|Release Date||: 2020-12-08|
|ISBN 10||: 1839160837|
|Pages||: 518 pages|
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.
This volume covers a selection of important research in the multifaceted field of food toxicology. With more than seven billion people in the world today and counting, advances in food toxicology have a direct bearing on food safety issues that are of concern to all humanity for the foreseeable future. Massive globalization, industrialization, and commercialization have affected every aspect of food production, the food supply chain, and food consumption. This informative volume offers the global perspectives of scientists in important areas related to biomarkers and nanosensors in food toxicology, toxicology of nanomaterials, chemicals in sanitation and packaging, additives, mycotoxins, endocrine disruptors, radionuclides, toxic metals, and waste-burning residues in food. The book also emphasizes regulatory toxicology and includes an interesting example case study. The challenge of sustainable and safe food for everyone needs a multidisciplinary and multi-sectorial approach from related industries and governments alike. Food chemical safety is an underappreciated aspect of consumer safety, and this volume seeks to help fill that gap by providing informative research for food scientists and researchers and many others.
A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
This book, Environmental Health Risk - Hazardous Factors to Living Species, is intended to provide a set of practical discussions and relevant tools for making risky decisions that require actions to reduce environmental health risk against environmental factors that may adversely impact human health or ecological balances. We aimed to compile information from diverse sources into a single volume to give some real examples extending concepts of those hazardous factors to living species that may stimulate new research ideas and trends in the relevant fields.
This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.
In today's world, everyone carries a toxic load of dozens of industrially produced chemicals in their bloodstream. Not only do these adversely affect the health of adults and children, but also, and more worryingly, they damage the development of unborn infants. The amniotic fluid of pregnant women has been found to contain a variety of chemicals, such as pesticides, plasticizers, disinfectant products, flame-retardants, surfactants and UV filters, many of which interfere with fetal physiology, especially thyroid hormone action. Thyroid hormone is vital for brain development, particularly for the fetus during pregnancy and for toddlers. In fact, children born to women who lack this thyroid hormone (or who are unwittingly exposed to thyroid-disrupting chemicals) have lower IQs and more neurodevelopmental problems. Evolution of the human brain has involved multiple changes and processes dependent on thyroid hormone. The urgent question thus arises: Is chemical pollution poisoning brain development and reversing evolution's most outstanding achievement: the human brain? And if so, as this book convincingly illuminates, what can be done about it both collectively and individually? Toxic Cocktail provides a clear view of how many environmental chemicals interfere with brain development. As a result, this book looks at how we define and test IQ, the evidence for IQ loss, and how chemical pollution and thyroid hormone disruption can be actors in this process, as well as increasing neurodevelopmental disease risk.
This edited book, Emerging Pollutants in the Environment Current and Further Implications, includes overviews by significant researchers on the topic of emerging pollutants toxicology, which covers the hazardous effects of common emerging xenobiotics employed in our every day anthropogenic activities. We hope that this book will meet the expectations and needs of all those who are interested in the negative implications of several emerging pollutants on living species.
Enables researchers to assess the effects of endocrine disrupters as well as comply with new environmental regulations Endocrine disrupters are chemicals—both man-made and natural—that interfere with the body's endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up-to-date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine-disrupting chemicals. Endocrine Disrupters is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including: Crustaceans and mollusks Insects Fish Amphibians and reptiles Birds and mammals Moreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost. Each chapter is written by one or more international experts in ecotoxicology, offering readers step-by-step guidance for implementing each method based on the latest research and the authors' firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers' comments. References at the end of each chapter guide readers to the literature in the field. Endocrine Disrupters is recommended for scientists who need to test chemicals for possible endocrine-disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemicals can be safely marketed.