Detection and Identification of Designer Drugs, a title in the Emerging Issues in Analytical Chemistry series, presents both an overview and a guide to techniques for anyone studying or engaging in designer drug analysis. Proliferation of the synthesis and use of designer drugs is a serious public health problem with social, economic and legal implications. Whether abuse is studied at the population level or the individual level, researchers need both background and highly detailed technical information on specific drugs and drug classes in order to combat the proliferation and highly damaging consequences of these substances. Author Brian F. Thomas provides a comprehensive discussion that emphasizes the potential threat to society, presents the ongoing challenges confronting the various laboratory approaches to detection and identification of new chemical entities and informs the development of improved analytical solutions for use in legislation, law enforcement and treatment. Summarizes the literature and evaluates the strengths and weaknesses of analytical methods for detecting and identifying designer drugs Offers authoritative information from author Brian F. Thomas, an expert with over 30 years of experience in the field Directs the reader to sources of further reading at the conclusion of each chapter Emphasizes the potential threat to society and presents ongoing challenges confronting various laboratory approaches to detection and identification of new chemical entities
|Author||: Teresa Kowalska,Mieczyslaw Sajewicz,Joseph Sherma|
|Publisher||: CRC Press|
|Release Date||: 2018-01-31|
|ISBN 10||: 1315313154|
|Pages||: 478 pages|
There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.
|Author||: Michael H. Baumann,Richard A. Glennon,Jenny L. Wiley|
|Release Date||: 2017-04-13|
|ISBN 10||: 3319524445|
|Pages||: 380 pages|
Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon.
|Author||: Wilfried M. A. Niessen,Ricardo A. Correa C.|
|Publisher||: John Wiley & Sons|
|Release Date||: 2017-01-03|
|ISBN 10||: 111929424X|
|Pages||: 416 pages|
Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
|Author||: Michael G. Bissell|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2012-09-24|
|ISBN 10||: 1455747874|
|Pages||: 240 pages|
This issue of Clinics in Laboratory Medicine, titled Toxicology Testing, includes the following topics; Progress in Clinical Toxicology Testing, The Prescription Drug Abuse Epidemic, Substance Abuse Among Healthcare Professionals, Pain Management Drug Testing, Ethanol Biomarkers, Newly-emerging Drugs of Abuse, Synthetic Cannabinoids, Synthetic Cathenones, Immunoassay Methodology in Drugs-of-abuse Testing, Toxicology Testing in Alternative Specimen Matrices, Principles and Procedures in Postmortem Toxicology, and Pharmacogenetics and the Future of Toxicology Testing. Advances in toxicology testing are paving the way for major improvements in the way scientists evaluate health risks posed by toxic chemicals. Toxicity tests help scientists better understand how the human body carries out normal functions that are key to maintaining health. Therefore, this topic is important to the field of Laboratory Medicine.
Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair. Unites an international team of leading experts to provide an update on the cutting-edge advances in the toxicological analysis of hair Demonstrates toxicological techniques relating to a variety of scenarios and exposure types Ideal resource for the further study of the psychoactive substances, drug-facilitated crimes, ecotoxicology, analytical toxicology, occupational toxicology, toxicity testing, and forensic toxicology Includes detailed instructions for the collection, preparation, and handling of hair, and how to best interpret results
|Author||: Amitava Dasgupta|
|Publisher||: Jones & Bartlett Learning|
|Release Date||: 2010|
|ISBN 10||: 9780763765897|
|Pages||: 230 pages|
The drug free workplace initiative was started in 1986 by President Ronald Reagan when he issued an executive order to develop guidelines for drug abuse testing for Federal Government employees. Since then, most state, government, and private employers have adopted the policy of a drug free workplace. Today, pre-employment drug testing is almost mandatory and passing the drug test is a condition for hire. A Health Educator's Guide to Understanding Drug Abuse Testing describes in layman’s language the process of testing for drugs and provides coverage of what potential employees are being tested for, how the tests are performed, and what foods and drugs may affect the test results and may jeopardize a person's chance of being hired. Written by a practicing toxicologist, this text gives health educators a solid foundation in the process of drug testing and helps them understand how different methods of cheating drug tests are rendered ineffectual.
|Author||: Amitava Dasgupta|
|Publisher||: Academic Press|
|Release Date||: 2019-01-10|
|ISBN 10||: 0128156082|
|Pages||: 560 pages|
Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians
|Author||: Barbara E. Gould,Ruthanna Dyer|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2014-04-11|
|ISBN 10||: 0323292402|
|Pages||: 736 pages|
A concise, easy-to-understand introduction to the fundamentals, Pathophysiology for the Health Professions, 4th Edition helps you learn to identify disease processes and disorders. Authors Barbara Gould and Ruthanna Dyer continue the tradition of a text known for its readability and vivid, full-color illustrations, updated with the latest research and clinical advances. Unique Challenge, Think About, and Emergency Treatment features help in applying the material to real-life situations. No matter which area in the healthcare field you may enter, this book provides essential preparation for conditions encountered in clinical practice. Concise and readable approach includes the information students need without overwhelming them, even if they have a limited scientific background. Unique Challenge feature asks "What can go wrong with this structure or system?" as a way to help students facilitate progress by using previously learned knowledge. Unique Think About boxes help with self-evaluation, test preparation, and review. Unique Emergency Treatment boxes list basic emergency measures; these can be modified to fit specific professions, established protocols, or practice settings. Research boxes discuss new developments, problem areas of pathophysiology, and complications associated with research. Warning Signs boxes summarize conditions that may develop in patients. Diagnostic tests and treatments are included for each of the major disorders. Case studies in each chapter provide a basis for discussion or can be used as an assignment. Study questions offer a self-assessment on the material in each chapter. Ready References in the appendix provide a quick lookup for anatomic terms, conversion tables, abbreviations and acronyms, diagnostic studies and tests, and more. A companion Evolve website includes web links, learning activities, content updates, and more. New content on the causes and trends related to disease, new drugs, technology, and treatment. Coverage of obesity and its complications, including an in-depth discussion of metabolic syndrome. Multiple disorder syndromes in the aged client. DNA, genetics and the Human Genome Project with current research on protein pathways in health (proteomics) and the implications for drug treatment and disease causation. Coverage of autism. Updated content on the H1N1 virus and communicable diseases; HIV, cancer causation, and immunology; and substance abuse to reflect common practices in the use of illicit (street) drugs as well as abuse of prescription medications. Case studies revised to emphasize chronic diseases, prevention, and acute care, and to apply to a wider range of health professions. Appendices reorganized for improved reference and lookup.
Over the last decade, and particularly during the recent five years, a rapidly increasing number of novel psychoactive substance (NPSs), often marketed as “designer drugs”, “legal highs”, “herbal highs”, “research or intermediate chemicals” and “laboratory reagents”, has appeared on the drug market in an effort to bypass controlled substance legislation. NPSs encompass a wide range of different compounds and drug classes but had been dominated by synthetic cannabinomimetics and psychostimulatory synthetic cathinones, so-called β-keto amphetamines. Compounds from the later class were first detected in Europe in 2004, and since then 103 new cathinones have been identified and reported to the European Monitoring Centre for Drugs and Drug Addiction, with 57 during the last two years. Synthetic cathinones – novel addictive and stimulatory psychoactive substances is the first publication of this kind that provides readers with background on chemical structures, detection, prevalence and motivation of use of the very popular group of NPSs. This book also presents comprehensive overview of the mechanisms of action, pharmacological activity, and main metabolic pathways of synthetic cathinones, followed by a detailed discussion of the acute and chronic toxicity associated with the use of these substances. Written by international experts in the field, this multi-authored book is a valuable reference not only for scientists, clinicians and academics, but also for readers representing different professional background who are involved in educational-prophylactic activities directed to harm reduction of psychoactive compounds.
This book focuses on a marvel approach that blends chemistry with forensic science and is used for the examination of controlled substances and clandestine operations. The book will particularly interest forensic chemists, forensic scientists, criminologists, and biochemists.
|Author||: Genevieve Pagalilauan|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2014-08-28|
|ISBN 10||: 0323323324|
|Pages||: 321 pages|
This issue of the Medical Clinics of North America is devoted to Psychiatric Diagnosis and Management in Primary Care and is edited by Dr. Genevieve Pagalilauan. Articles in this issue include: Psychopharmacology; Office-based Screening of Common Psychiatric Conditions; Depression; Anxiety Disorders; Bipolar Disorder; Borderline Personality Disorder; Grief Reaction, Adjustment Disorder, Seasonal Affective Disorder; Somatiform Disorders; Addiction Disorders; Sleep disorders; Geriatric Psychiatry; Autism Spectrum Disorders in Adults; and Medical Conditions with Neuropsychiatric Manifestations.
Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials. Features accessible language for healthcare and safety professionals who are not experts in laboratory procedures Provides examples from clinical and everyday situations Explains how to interpret laboratory results and the latest genetic factors regarding drug and alcohol abuse
An increasing number of novel psychoactive drugs are currently available and sold as 'legal highs' or 'research chemicals'. These New Psychoactive Substances (NPS) constitute a broad range of hundreds of natural and synthetic drugs, including synthetic cannabinoids, synthetic cathinones, synthetic opioids and other classes, which use has resulted in a significantly growing number of intoxication and mortality, as reported by emergency and poison centres from all over the world. Definition of “NPS” includes any substance that has recently become available and has been designed purposely to replace illegal drugs, although not necessarily of new synthesis. Use of NPS is dramatically increased in the last decade and represents a serious risk for the public health. Their ever-evolving chemical structure, the possibility to distribute in real time through the Internet and social networks information about their use and effects have dramatically challenged public health and drug policies internationally. NPS recently attracted great attention, but most are still unregulated and proposed online as legal alternatives to traditional illicit drugs. Unfortunately, this area is still poorly investigated and very limited information are available so far on their nature and potential risks. The phenomenon of NPS requires multi-national and multi-disciplinary collaborations to improve our knowledge on this changing drug market, to share information and define good practices at a global level. Political and educational efforts are indispensable to regulate this mutable scenario and to inform the public about health consequences of NPS use. Clinicians and emergency staff should be aware that NPS may cause severe health consequences and unexpected adverse effects, and be informed on how to recognized and treat specific intoxication cases. Considering the widespread use of NPS and paucity of information about their toxicology and pharmacology, this Research Topic will be useful to understand the new trends in the scenario of drug use, abuse and addiction to inform professionals and general public about the health problems caused by NPS and to help drug-control policies to adopt suitable control measures.
|Author||: Marc Galanter,Herbert D. Kleber,Kathleen T. Brady|
|Publisher||: American Psychiatric Pub|
|Release Date||: 2015-04-01|
|ISBN 10||: 1585625183|
|Pages||: 980 pages|
No other text available today offers what The American Psychiatric Publishing Textbook of Substance Abuse Treatment can: completely updated treatment information on a broad range of substance use disorders that is consistent with the new DSM-5 classification and thus reflective of how psychiatry is practiced today. Designed for researchers and mental health professionals ranging from trainee to licensed practitioner, the book is also appropriate for a diverse array of rehabilitation settings, from inpatient to community-based treatment. Full coverage is provided on 12-step programs, as well, including the latest outcomes research. Much of the material is new to this edition: A chapter has been added on science in the treatment of substance abuse, in which the authors discuss the history of scientific intervention in substance abuse and explore what happens to the brain when addicting drugs are consumed, review animal models and imaging techniques, and discuss current progress in the science of addiction. Chapters have been added on screening and brief intervention, reflecting the development of brief screening tools and research on the efficacy of interventions, and the role of "recovery" in chronic care disease management -- specifically what the treatment models for alcohol dependence and for diabetes can effectively borrow from each other. A new chapter focuses on the treatment of alcohol intoxication and withdrawal -- the first steps in treatment of alcohol use disorder. Two chapters on marijuana -- one on the neurobiology and one addressing treatment have been added. Given the accelerating trend toward decriminalization and legalization of this substance, clinicians will find this information of increasing importance. The section on substance use issues among gay men and lesbians has been expanded to include bisexual and transgender people in recognition of increased diversity among the population. Well-structured, with topics that follow logically and many practical, treatment-oriented features, such as quick reference tables and lists of recommended readings, The American Psychiatric Publishing Textbook of Substance Abuse Treatment is a classic that will enhance the education and practice of clinicians.
Chromatographic & Electrophoretic Techniques, Fourth Edition, Volume I: Paper and Thin Layer Chromatography presents the methods of paper and thin layer chromatography. This book discusses the practical approach in the application of paper and thin layer chromatography techniques in the biological sciences. Organized into 18 chapters, this edition begins with an overview of the clinical aspects related to the detection of those metabolic diseases that can result in serious illness presenting in infancy and early childhood. This text then discusses the three major types of screening for inherited metabolic disorders in which paper or thin-layer chromatography are being used, including screening the healthy newborn population, screening the sick hospitalized child, and screening mentally retarded patients. Other chapters consider the procedures for thin layer chromatography. This book discusses as well the complexity of amino acid mixtures present in natural products. The final chapter deals with the detection of synthetic basic drugs. This book is a valuable resource for chemists and toxicologists.
Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
|Author||: Mark A. Rothstein|
|Publisher||: Bna Books|
|Release Date||: 1989|
|Pages||: 296 pages|
|Author||: Richard B. Silverman|
|Release Date||: 2012-12-02|
|ISBN 10||: 0080571239|
|Pages||: 422 pages|
This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications