dendrimer based nanotherapeutics

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Dendrimer-Based Nanotherapeutics
Author : Prashant Kesharwani
Publisher : Academic Press
Release Date : 2021-04-27
ISBN 10 : 0128212519
Pages : 484 pages

Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields. Discusses various routes such as oral, pulmonary, transdermal, delivery and local administration of dendrimer delivery of bioactive Explores a wide range of applications of dendrimer-based drug delivery using the latest advancements in nanomedicine Provides the most recent research on dendrimers as well as context and background, providing a useful resource for all levels of researcher

Pharmaceutical Applications of Dendrimers
Author : Hitesh Kulhari,Abhay Singh Chauhan
Publisher : Elsevier
Release Date : 2019-11-15
ISBN 10 : 9780128145272
Pages : 500 pages

Dendrimers are engineered nano-sized macromolecule with a high degree of molecular uniformity, narrow size distribution, tunable size, multivalency and high surface functionality. These favourable characteristics make dendrimers effective drug delivery carriers. As a result, dendrimers have demonstrated wide applicability in nanopharmaceuticals Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in solubilisation of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. Dendrimers have been successfully used as a solubility enhancer and drug delivery carrier. Dendrimer-based formulations have also been used for transfection or gene delivery. Diagnostic applications of dendrimers include MRI contrast agent and imaging of diseased areas. In addition, dendrimers such as PPI and PAMAM are reported to possess anti-inflammatory, antimicrobial and antiviral activities. In past five years, photosensitizers such as rose Bengal and protoporphyrin IX have also been delivered using PAMAM and PPI dendrimers for the treatment of cancer. These important and emerging uses are discussed here in detail. This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery. Explores the role of dendrimers in the design of dendritic nanoplateforms for targeted drug and gene delivery systems Discusses the potential of dendrimers in preformulation and formulation development Addresses the clinical and regulatory challenges in the development of dendrimer-based formulations

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer
Author : Prashant Kesharwani
Publisher : Academic Press
Release Date : 2019-01-26
ISBN 10 : 0128163674
Pages : 340 pages

Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers

Dendrimer-based Nanomedicine
Author : István J. Majoros,James R. Baker (Jr.)
Publisher : N.A
Release Date : 2008
ISBN 10 : 9780367806088
Pages : 407 pages

In recent decades, dendrimers ? free-shaped synthetic macromolecules ? have garnered a great deal of scientific interest because of their unique molecular nanostructure. Used in a variety of scientific applications, dendrimers are now widely regarded as a safer, more precise and more effective way to practice medicine.This book compiles and details cutting-edge research in science and medicine from the interdisciplinary team of the Michigan Nanotechnology Institute for Medicine and Biological Sciences, which is currently revolutionizing drug delivery techniques through the development of engineered nanodevices. Edited by Istvan J. Majoros and James R. Baker Jr, two prominent nanotechnology researchers, this book will appeal to anyone involved in nanotechnology, macromolecular science, cancer therapy or drug delivery research.

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics
Author : Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye
Publisher : Academic Press
Release Date : 2019-07-08
ISBN 10 : 0128173319
Pages : 432 pages

Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Polymeric Nanomaterials in Nanotherapeutics
Author : N.A
Publisher : Elsevier
Release Date : 2018-10-26
ISBN 10 : 0128139331
Pages : 558 pages

Polymeric Nanomaterials in Nanotherapeutics describes how polymeric nanosensors and nanorobotics are used for biomedical instrumentation, surgery, diagnosis and targeted drug delivery for cancer, pharmacokinetics, monitoring of diabetes and healthcare. Key areas of coverage include drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy tissues and cells. The book demonstrates how these are applied to dental work, wound healing, cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, metabolic diseases, and more. Methods of administration discussed include oral, dental, topical and transdermal, pulmonary and nasal, ocular, vaginal, and brain drug delivery and targeting. Drug delivery topics treated in several subchapters includes materials for active targeting and cases study of polymeric nanomaterials in clinical trials. The toxicity and regulatory status of therapeutic polymeric nanomaterials are also examined. The book gives a broad perspective on the topic for researchers, postgraduate students and professionals in the biomaterials, biotechnology, and biomedical fields. Shows how the properties of polymeric nanomaterials can be used to create more efficient medical treatments/therapies Demonstrates the potential and range of applications of polymeric nanomaterials in disease prevention, diagnosis, drug development, and for improving treatment outcomes Accurately explains how nanotherapeutics can help in solving problems in the field through the latest technologies and formulations

Author : Ezharul Hoque Chowdhury
Publisher : CRC Press
Release Date : 2016-04-21
ISBN 10 : 1498707521
Pages : 336 pages

The emergence of nanotherapeutics is attributable to the integration of nanotechnology, recombinant DNA technology, and synthetic organic chemistry with medicine for treating critical human diseases in a more efficient and specific molecular approach than therapy with conventionally-designed and formulated drugs. Nanotherapeutics: From Laboratory to Clinic comprehensively discusses the current shortcomings for delivery of classical (small) drugs, macromolecular therapeutics, and recombinant vaccine via the common intravascular and extravascular routes. The book describes the synthetic/chemical engineering methods as well as recombinant, hybridoma, and phage display technologies to fabricate different types of nanoparticulate carriers and drugs. It also reveals the diversified approaches undertaken by harnessing nanotechnology to overcome the multistep extracellular and intracellular barriers and to facilitate the development of novel strategies for therapeutic delivery and imaging. The author elaborates on the preclinical and clinical trials of potential nanoparticle-based products in animal models and patients and the approval/commercialization of nanotherapeutics, addressing all relevant human diseases. A focus on the above issues in a concise but illustrative manner fills the gap between the laboratory findings originating from the research on identification of cellular and systemic barriers of classical and macromolecular drugs along with development of strategies for fabrication and testing of nanotherapeutics, and the clinical outcomes emanating from the testing of the selected potential nanotherapeutics on patients of particular diseases. The book also fills a gap in the existing literature between the design and development of diversified nanotherapeutics for various purposes and the investigation and evaluation of potential barriers and resultant therapeutic efficacy of those nano-medicine formulations.

Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release Date : 2017-05-03
ISBN 10 : 0323527264
Pages : 372 pages

Multifunctional Systems for Combined Delivery, Biosensing, and Diagnostics explores how multifunctional nanocarriers are being used in combined delivery and diagnostics in contemporary medicine. Particular attention is given to efforts to i) reduce the side effects of therapeutic agents, ii) increase the pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. The chapters focus on applications of nanostructured materials and nanocarriers, highlighting how these can be used effectively in both diagnosis and delivery. This applied focus makes the book an important reference source for those wanting to learn more about how specific nanomaterials and nanotechnology systems can help to solve drug delivery and diagnostics problems. This book is a valuable resource for materials scientists, bioengineers, and medical researchers who are looking for an applications-oriented guide on how nanotechnology and nanomaterials can be used effectively throughout the medical treatment process, from diagnosis to treatment. Explores the benefits of using a variety of nanomaterials as drug delivery agents Explains how nanocarriers can reduce the side effects of therapeutic agents Provides an analysis of the pros and cons of using specific nanocarriers to solve particular diagnosis and delivery problems

Author : Gil Gonçalves,Gerard Tobias
Publisher : Springer
Release Date : 2018-07-03
ISBN 10 : 3319898787
Pages : 455 pages

This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
Publisher : Woodhead Publishing
Release Date : 2017-04-04
ISBN 10 : 0081005636
Pages : 256 pages

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Nanotechnology Based Approaches for Tuberculosis Treatment
Author : Prashant Kesharwani
Publisher : Academic Press
Release Date : 2020-06-10
ISBN 10 : 0128226110
Pages : 284 pages

Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers

Nanoparticulate Drug Delivery Systems
Author : Raj K. Keservani,Anil K. Sharma
Publisher : CRC Press
Release Date : 2019-01-23
ISBN 10 : 1351137247
Pages : 422 pages

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.