computational epigenetics and diseases

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Computational Epigenetics and Diseases
Author : N.A
Publisher : Academic Press
Release Date : 2019-02-06
ISBN 10 : 0128145145
Pages : 450 pages
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Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Exam Prep for: Computational Epigenetics and Diseases
Author : N.A
Publisher : N.A
Release Date :
ISBN 10 :
Pages : 329 pages
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Personalized Epigenetics
Author : Trygve Tollefsbol
Publisher : Academic Press
Release Date : 2015-04-28
ISBN 10 : 0128004363
Pages : 610 pages
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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Epigenetics in Cardiovascular Disease
Author : Yvan Devaux,Emma Louise Robinson
Publisher : Academic Press
Release Date : 2021-03-06
ISBN 10 : 012822259X
Pages : 498 pages
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Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

Epigenetics Methods
Author : Trygve Tollefsbol
Publisher : Academic Press
Release Date : 2020-07-08
ISBN 10 : 0128194154
Pages : 736 pages
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In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Epigenetics of the Immune System
Author : Dieter Kabelitz,Jaydeep Bhat
Publisher : Academic Press
Release Date : 2020-06-04
ISBN 10 : 0128179651
Pages : 384 pages
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Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Epigenetic Technological Applications
Author : Yujun George Zheng
Publisher : Academic Press
Release Date : 2015-05-30
ISBN 10 : 0128013273
Pages : 516 pages
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Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics

Epigenetics in Human Disease
Author : Trygve O. Tollefsbol
Publisher : Academic Press
Release Date : 2012
ISBN 10 : 0123884152
Pages : 577 pages
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Toxicology and Epigenetics
Author : Saura C. Sahu
Publisher : John Wiley & Sons
Release Date : 2012-08-23
ISBN 10 : 1118349067
Pages : 688 pages
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Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensionalcharacter of this emerging area of toxicology, describingcutting-edge molecular technologies to unravel epigenetic changes,the use of in vivo and in vitro models, as well asthe potential use of toxicological epigenetics in regulatoryenvironments. An international team of experts consider theinterplay between epigenetics and toxicology in a number of areas,including environmental, nutritional, pharmacological, andcomputational toxicology, nanomaterials, proteomics andmetabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact indevelopment and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight intothe current trends and future directions of research in thisrapidly expanding field for investigators, toxicologists, riskassessors and regulators in academia, industry and government.

Epigenetic Biomarkers and Diagnostics
Author : José Luis García-Giménez
Publisher : Academic Press
Release Date : 2015-12-07
ISBN 10 : 0128019212
Pages : 696 pages
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Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Bioinformatics for Diagnosis, Prognosis and Treatment of Complex Diseases
Author : Bairong Shen
Publisher : Springer Science & Business Media
Release Date : 2013-11-25
ISBN 10 : 9400779755
Pages : 220 pages
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The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc. Dr. Bairong Shen is Professor and Director of Center for Systems Biology, Soochow University; he is also Director of Taicang Center for Translational Bioinformatics.

Genetics and Genomics of Eye Disease
Author : Xiaoyi Raymond Gao
Publisher : Academic Press
Release Date : 2019-09-12
ISBN 10 : 0128167270
Pages : 383 pages
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Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. Offers thorough guidance on conducting genetic and genomic studies of eye disease Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling