companion and complementary diagnostics

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Companion and Complementary Diagnostics
Author : Jan Trøst Jørgensen
Publisher : Academic Press
Release Date : 2019-05-08
ISBN 10 : 0128135409
Pages : 508 pages
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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

Companion and Complementary Diagnostics
Author : Jan Trøst Jørgensen
Publisher : Academic Press
Release Date : 2019-04-15
ISBN 10 : 9780128135396
Pages : 305 pages
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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

Companion Diagnostics (CDx) in Precision Medicine
Author : Il-Jin Kim
Publisher : CRC Press
Release Date : 2019-03-06
ISBN 10 : 1000007219
Pages : 256 pages
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There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

Predictive Biomarkers in Oncology
Author : Sunil Badve,George Louis Kumar
Publisher : Springer
Release Date : 2018-12-06
ISBN 10 : 3319952285
Pages : 642 pages
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“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.

An R Companion to Applied Regression
Author : John Fox,Sanford Weisberg
Publisher : SAGE Publications
Release Date : 2018-09-27
ISBN 10 : 1544336454
Pages : 608 pages
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An R Companion to Applied Regression is a broad introduction to the R statistical computing environment in the context of applied regression analysis. John Fox and Sanford Weisberg provide a step-by-step guide to using the free statistical software R, an emphasis on integrating statistical computing in R with the practice of data analysis, coverage of generalized linear models, and substantial web-based support materials. The Third Edition has been reorganized and includes a new chapter on mixed-effects models, new and updated data sets, and a de-emphasis on statistical programming, while retaining a general introduction to basic R programming. The authors have substantially updated both the car and effects packages for R for this edition, introducing additional capabilities and making the software more consistent and easier to use. They also advocate an everyday data-analysis workflow that encourages reproducible research. To this end, they provide coverage of RStudio, an interactive development environment for R that allows readers to organize and document their work in a simple and intuitive fashion, and then easily share their results with others. Also included is coverage of R Markdown, showing how to create documents that mix R commands with explanatory text.

Consumer Health Informatics
Author : Deborah Lewis,Gunther Eysenbach,Rita Kukafka,P. Zoe Stavri,Holly Jimison
Publisher : Springer Science & Business Media
Release Date : 2006-03-30
ISBN 10 : 0387276521
Pages : 258 pages
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According to the Pew Foundation’s "Internet in American Life Study," over 60 million Americans per year use the Internet to search for health information. All those concerned with healthcare and how to obtain personally relevant medical information form a large additional target group Many Medical Informatics programs–both in the United States and abroad–include a course in Consumer Health Informatics as part of their curriculum. This book, designed for use in a classroom, will be the first textbook dedicated solely to the specific concerns of consumer health informatics Consumer Health Informatics is an interactive text; filled with case studies and discussion questions With international authorship and edited by five leaders in the field, Consumer Health Informatics has tapped some of the best resources in informatics today

Diagnosis and Management of Lameness in the Horse - E-Book
Author : Michael W. Ross,Sue J. Dyson
Publisher : Elsevier Health Sciences
Release Date : 2010-11-11
ISBN 10 : 1437711766
Pages : 1424 pages
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Covering many different diagnostic tools, this essential resource explores both traditional treatments and alternative therapies for conditions that can cause gait abnormalities in horses. Broader in scope than any other book of its kind, this edition describes equine sporting activities and specific lameness conditions in major sport horse types, and includes up-to-date information on all imaging modalities. This title includes additional digital media when purchased in print format. For this digital book edition, media content may not be included. Cutting-edge information on diagnostic application for computed tomography and magnetic resonance imaging includes the most comprehensive section available on MRI in the live horse. Coverage of traditional treatment modalities also includes many aspects of alternative therapy, with a practical and realistic perspective on prognosis. An examination of the various types of horses used in sports describes the lameness conditions to which each horse type is particularly prone, as well as differences in prognosis. Guidelines on how to proceed when a diagnosis cannot easily be reached help you manage conditions when faced with the limitations of current diagnostic capabilities. Clinical examination and diagnostic analgesia are given a special emphasis. Practical, hands-on information covers a wide range of horse types from around the world. A global perspective is provided by a team of international authors, editors, and contributors. A full-color insert shows thermography images. Updated chapters include the most current information on topics such as MRI, foot pain, stem cell therapy, and shock wave treatment. Two new chapters include The Biomechanics of the Equine Limb and its Effect on Lameness and Clinical Use of Stem Cells, Marrow Components, and Other Growth Factors. The chapter on the hock has been expanded substantially, and the section on lameness associated with the foot has been completely rewritten to include state-of-the-art information based on what has been learned from MRI. Many new figures appear throughout the book.

A Personal History of Nuclear Medicine
Author : Henry N. Wagner
Publisher : Springer Science & Business Media
Release Date : 2007-12-23
ISBN 10 : 1846280729
Pages : 299 pages
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A Personal History of Nuclear Medicine is an account of how nuclear medicine developed, and its basic philosophy in the past, present and future. The book outlines the history of the development of nuclear medicine as experienced by the author and describes the hurdles that nuclear medicine has had to face, in view of the perception of risk of radiation. It also explains how nuclear medicine solves medical problems in clinical practice and how it has contributed to a new definition of disease. The book concludes with future projections of the likely developments in this area in the next 50 years. Target market: nuclear medicine professionals as well non-nuclear medicine physicians and the public

Diagnostic Molecular Biology
Author : Chang-Hui Shen
Publisher : Academic Press
Release Date : 2019-04-02
ISBN 10 : 012802867X
Pages : 471 pages
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Diagnostic Molecular Biology describes the fundamentals of molecular biology in a clear, concise manner to aid in the comprehension of this complex subject. Each technique described in this book is explained within its conceptual framework to enhance understanding. The targeted approach covers the principles of molecular biology including the basic knowledge of nucleic acids, proteins, and genomes as well as the basic techniques and instrumentations that are often used in the field of molecular biology with detailed procedures and explanations. This book also covers the applications of the principles and techniques currently employed in the clinical laboratory. • Provides an understanding of which techniques are used in diagnosis at the molecular level • Explains the basic principles of molecular biology and their application in the clinical diagnosis of diseases • Places protocols in context with practical applications

A Classical Introduction to Cryptography Exercise Book
Author : Thomas Baigneres,Pascal Junod,Yi Lu,Jean Monnerat,Serge Vaudenay
Publisher : Springer Science & Business Media
Release Date : 2007-08-06
ISBN 10 : 038728835X
Pages : 254 pages
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TO CRYPTOGRAPHY EXERCISE BOOK Thomas Baignkres EPFL, Switzerland Pascal Junod EPFL, Switzerland Yi Lu EPFL, Switzerland Jean Monnerat EPFL, Switzerland Serge Vaudenay EPFL, Switzerland Springer - Thomas Baignbres Pascal Junod EPFL - I&C - LASEC Lausanne, Switzerland Lausanne, Switzerland Yi Lu Jean Monnerat EPFL - I&C - LASEC EPFL-I&C-LASEC Lausanne, Switzerland Lausanne, Switzerland Serge Vaudenay Lausanne, Switzerland Library of Congress Cataloging-in-Publication Data A C.I.P. Catalogue record for this book is available from the Library of Congress. A CLASSICAL INTRODUCTION TO CRYPTOGRAPHY EXERCISE BOOK by Thomas Baignkres, Palcal Junod, Yi Lu, Jean Monnerat and Serge Vaudenay ISBN- 10: 0-387-27934-2 e-ISBN-10: 0-387-28835-X ISBN- 13: 978-0-387-27934-3 e-ISBN- 13: 978-0-387-28835-2 Printed on acid-free paper. O 2006 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now know or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if the are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America.

Flexibility: A Concise Guide
Author : Laurence E. Holt,Thomas E. Pelham,Jason Holt
Publisher : Springer Science & Business Media
Release Date : 2008-01-07
ISBN 10 : 160327104X
Pages : 162 pages
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Here is a definitive guide to flexibility that revises the conceptual framework of the field. From the conceptual foundations of research to the practical applications of stretching techniques in a number of domains, this book provides a fresh perspective on flexibility, one that challenges current thinking and professional practice. It covers all major types of flexibility technique and training, with an emphasis on when and how to use each method safely and effectively. Specific applications to rehabilitation, sport, fitness, and dance make this book an invaluable resource for all practitioners and professionals in the field of human movement.

Bayesian Ideas and Data Analysis
Author : Ronald Christensen,Wesley Johnson,Adam Branscum,Timothy E Hanson
Publisher : CRC Press
Release Date : 2011-07-07
ISBN 10 : 1439803552
Pages : 516 pages
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Emphasizing the use of WinBUGS and R to analyze real data, Bayesian Ideas and Data Analysis: An Introduction for Scientists and Statisticians presents statistical tools to address scientific questions. It highlights foundational issues in statistics, the importance of making accurate predictions, and the need for scientists and statisticians to collaborate in analyzing data. The WinBUGS code provided offers a convenient platform to model and analyze a wide range of data. The first five chapters of the book contain core material that spans basic Bayesian ideas, calculations, and inference, including modeling one and two sample data from traditional sampling models. The text then covers Monte Carlo methods, such as Markov chain Monte Carlo (MCMC) simulation. After discussing linear structures in regression, it presents binomial regression, normal regression, analysis of variance, and Poisson regression, before extending these methods to handle correlated data. The authors also examine survival analysis and binary diagnostic testing. A complementary chapter on diagnostic testing for continuous outcomes is available on the book’s website. The last chapter on nonparametric inference explores density estimation and flexible regression modeling of mean functions. The appropriate statistical analysis of data involves a collaborative effort between scientists and statisticians. Exemplifying this approach, Bayesian Ideas and Data Analysis focuses on the necessary tools and concepts for modeling and analyzing scientific data. Data sets and codes are provided on a supplemental website.