cellular response to biomaterials

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Cellular Response to Biomaterials
Author : Lucy Di Silvio
Publisher : Elsevier
Release Date : 2008-12-22
ISBN 10 : 184569547X
Pages : 648 pages

The response of cells to biomaterials is critical in medical devices. Traditionally inert biomaterials were used to minimise the reaction in cells in contact with the material. However, it has been realised that specific cell responses may be beneficial in such areas as encouraging adhesion, healing or cell multiplication. Cellular response to biomaterials discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. Part one discusses cell responses to a variety of polymers and ceramics with chapters on such topics as degradable polymers and biocompatibility. Part two covers cell responses and regenerative medicine with coverage of themes such as vascular grafts, nerve repair and Bioglass®. Part three examines the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion and surface modification of titanium implants. With its distinguished editor and team of international contributors, Cellular response to biomaterials is an essential read for those researching or studying medical devices in industry and academia. Examines the response of cells to a wide range of biomaterials targeted at specific medical applications Discusses cell responses and regenerative medicine with specific chapters on vascular grafts and nerve repair Assesses the effect of surfaces and proteins on cell response including the influence of plasma proteins on cell adhesion and surface modification of titanium implants

Biomaterials and Immune Response
Author : Nihal Engin Vrana
Publisher : CRC Press
Release Date : 2018-07-20
ISBN 10 : 1351377558
Pages : 249 pages

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Host Response to Biomaterials
Author : Stephen F Badylak
Publisher : Academic Press
Release Date : 2015-05-08
ISBN 10 : 0128005009
Pages : 460 pages

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Handbook of Biomaterials Biocompatibility
Author : Masoud Mozafari
Publisher : Woodhead Publishing Limited
Release Date : 2020-06
ISBN 10 : 9780081029671
Pages : 625 pages

Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials

Cell and Material Interface
Author : Nihal Engin Vrana
Publisher : CRC Press
Release Date : 2018-09-03
ISBN 10 : 1482256134
Pages : 270 pages

A significant portion of biomedical applications necessitates the establishment of an interface between the cells of the patient and the components of the device. In many cases, such as in implants and engineered tissues, the interaction of the cells with the biomaterial is one of the main determinants of the success of the system. Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies explores this interaction and its control at length scales ranging from the nano to the macro. Featuring contributions from leading molecular biologists, chemists, and material scientists, this authoritative reference: Presents practical examples of cell and material interface-based applications Reflects the interdisciplinary nature of bioengineering, covering topics such as biosensing, immunology, and controlled delivery Explains the role of the cell and material interface in the context of cardiac and skin tissue engineering, nanoparticles, natural polymers, and more Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies addresses concepts essential to biomaterial production methods and cell and material interactions. The book provides a solid starting point for elucidating and exploiting the different aspects of cellular interactions with materials for biomedical engineering.

The Immune Response to Implanted Materials and Devices
Author : Bruna Corradetti
Publisher : Springer
Release Date : 2016-11-30
ISBN 10 : 3319454331
Pages : 241 pages

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Immunomodulatory Biomaterials
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Release Date : 2021-07-01
ISBN 10 : 0128214562
Pages : 345 pages

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair
Author : Mario Barbosa,M Cristina L Martins
Publisher : Woodhead Publishing
Release Date : 2017-09-25
ISBN 10 : 008100852X
Pages : 390 pages

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers

Oxidative Stress and Biomaterials
Author : Thomas Dziubla,D Allan Butterfield
Publisher : Academic Press
Release Date : 2016-05-31
ISBN 10 : 0128032707
Pages : 404 pages

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Biomaterials Science
Author : Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
Publisher : Elsevier
Release Date : 2004-08-18
ISBN 10 : 008047036X
Pages : 864 pages

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. Provides comprehensive coverage of principles and applications of all classes of biomaterials Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites Endorsed by the Society for Biomaterials

Bio-Implant Interface
Author : J.E. Ellingsen,S.P. Lyngstadaas
Publisher : CRC Press
Release Date : 2003-04-29
ISBN 10 : 1135508216
Pages : 464 pages

Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning

In Situ Tissue Regeneration
Author : Sang Jin Lee,Anthony Atala,James J Yoo
Publisher : Academic Press
Release Date : 2016-07-17
ISBN 10 : 012802500X
Pages : 458 pages

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry