breaking tolerance to pancreatic cancer unresponsiveness to chemotherapy

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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Author : Ganji Purnachandra Nagaraju
Publisher : Academic Press
Release Date : 2019-02-26
ISBN 10 : 0128176628
Pages : 223 pages

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Theranostic Approach for Pancreatic Cancer
Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publisher : Academic Press
Release Date : 2019-08-19
ISBN 10 : 0128194588
Pages : 410 pages

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Improving the Therapeutic Ratio in Head and Neck Cancer
Author : N.A
Publisher : Academic Press
Release Date : 2019-10-04
ISBN 10 : 0128178698
Pages : 376 pages

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
Author : N.A
Publisher : Academic Press
Release Date : 2019-11-07
ISBN 10 : 0128141417
Pages : 394 pages

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner Describes the involvement of efflux pumps in cancer resistance in different cancer types Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance

Therapeutic Strategies to Overcome ALK Resistance in Cancer
Author : Luc Friboulet
Publisher : Academic Press
Release Date : 2021-01-18
ISBN 10 : 0128217790
Pages : 216 pages

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

A Theranostic and Precision Medicine Approach for Female-Specific Cancers
Author : Rama Rao Malla,Ganji Purnachandra Nagaraju
Publisher : Academic Press
Release Date : 2020-11-06
ISBN 10 : 0128226927
Pages : 318 pages

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Role of Transcription Factors in Gastrointestinal Malignancies
Author : Ganji Purnachandra Nagaraju,Pallaval Veera Bramhachari
Publisher : Springer
Release Date : 2018-03-27
ISBN 10 : 9811067287
Pages : 513 pages

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy
Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
Release Date : 2013-07-04
ISBN 10 : 1461470706
Pages : 260 pages

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Critical Dietary Factors in Cancer Chemoprevention
Author : Mohammad Fahad Ullah,Aamir Ahmad
Publisher : Springer
Release Date : 2015-10-06
ISBN 10 : 3319214616
Pages : 373 pages

This book focuses on the prophylactic potential of diet-derived factors in primary prevention of cancer. It is written by a group of highly reputed experts in the area of dietary agents and cancer chemoprevention. The translational potential of dietary factors from epidemiological, laboratory and clinical studies as prevention strategy in normal and risk populations is highlighted. The work presents options of routine inclusion of specific dietary regimens for prevention as well as therapeutic strategy for better management through adjuvant interventions in cancer treatment.

Role of Tyrosine Kinases in Gastrointestinal Malignancies
Author : Ganji Purnachandra Nagaraju
Publisher : Springer
Release Date : 2018-09-27
ISBN 10 : 9811314861
Pages : 241 pages

The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.

Immunotherapy of Cancer
Author : Yoshiyuki Yamaguchi
Publisher : Springer
Release Date : 2016-02-22
ISBN 10 : 4431550313
Pages : 358 pages

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Essentials of Interventional Cancer Pain Management
Author : Amitabh Gulati,Vinay Puttanniah,Brian M. Bruel,William S. Rosenberg,Joseph C. Hung
Publisher : Springer
Release Date : 2018-12-28
ISBN 10 : 3319996843
Pages : 530 pages

This text provides a comprehensive review and expertise on various interventional cancer pain procedures. The first part of the text addresses the lack of consistency seen in the literature regarding interventional treatment options for specific cancer pain syndromes. Initially, it discusses primary cancer and treatment-related cancer pain syndromes that physicians may encounter when managing cancer patients. The implementation of paradigms that can be used in treating specific groups of cancer such as breast cancer, follows. The remainder of the text delves into a more common approach to addressing interventional cancer pain medicine. After discussing interventional options that are commonly employed by physicians, the text investigates how surgeons may address some of the more severe pain syndromes, and covers the most important interventional available for our patients, intrathecal drug delivery. Chapters also cover radiologic options in targeted neurolysis and ablative techniques, specifically for bone metastasis, rehabilitation to address patients’ quality of life and function, and integrative and psychological therapies. Essentials of Interventional Cancer Pain Management globally assesses and addresses patients’ needs throughout the cancer journey. Written by experts in the field, and packed with copious tables, figures, and flow charts, this book is a must-have for pain physicians, residents, and fellows.

100 Cases in Clinical Medicine, Second Edition
Author : John Rees,James Pattison,Gwyn Williams
Publisher : CRC Press
Release Date : 2011-12-09
ISBN 10 : 1444166557
Pages : 272 pages

100 Cases in Clinical Medicine is an indispensable revision tool for medical students preparing for clinical examinations or OSCEs. Using scenarios which mimic daily life, the cases will interest students in clinical problems and help them develop their clinical reasoning skills, with each case presenting details of a patient's medical history and the key findings of a clinical examination, together with initial investigation results for evaluation. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible management plan, while the answer pages will help the student to understand the processes that a clinician goes through in dealing with the problems presented. Contents are organised to provide a quick review of each body system, with a selection of cases relevant to that specific system, then the majority are presented randomly to mimic real life in a GP surgery or emergency department. New to this edition: a review of each body system as well as random cases; new page design with a second colour used throughout; and brought up-to-date with 25% new cases.

Cancer in Children
Author : Michael C. G. Stevens,Hubert N. Caron,Andrea Biondi
Publisher : Oxford University Press
Release Date : 2012
ISBN 10 : 0199599416
Pages : 400 pages

This new edition brings together an international group of highly respected editors and contributors to provide evidence-based information on how to investigate and treat the common cancers in childhood. In a clear and concise way, it covers the aetiology, symptoms, and treatment of cancer in children, the complications that can arise during treatment, and the various outcomes of the illness. State-of-the-art descriptions of what is basic and essential for management is included; there are new chapters on clinical trials, evidence based practice, the treatment of cancer in less well-resourced countries, stem cell and immunotherapy, other malignant / borderline haematological conditions (myelodysplasia and myeloproliferative disorders), and on imaging. These all reflect important changes in the focus of the speciality in recent years. Aimed at paediatric oncologists, and trainees in oncology and paediatrics, this leading text will also appeal to paediatric nurses, cancer nurses, and paramedical paediatric staff.

Anti-cancer Drugs
Author : Jasna Bankovic
Publisher : BoD – Books on Demand
Release Date : 2016-12-07
ISBN 10 : 9535128132
Pages : 196 pages

We are in constant search for new therapeutic options to cure cancer. In this book, you can find out how scientists throughout the world deal with this problem. Readers will learn how to engage nature, chemical synthesis, and cell machinery to design new anticancer agents. Nature has already been very generous in providing us different compounds which are in widespread application. Starting from these resources, various synthetic processes are applied to create synthetic drugs which can be then obtained in large quantities. Also, the cell by itself provides different possibilities to meet the constantly increasing requirements for successful therapy. Explore the book and find out what are the new ways to fight cancer.

Immune Regulation
Author : Marc Feldmann,N. A. Mitchison
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
ISBN 10 : 1461249961
Pages : 392 pages

Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.

Theranostics Approaches to Gastric and Colon Cancer
Author : Ganji Seeta Rama Raju,L.V.K.S. Bhaskar
Publisher : Springer Nature
Release Date : 2020-03-04
ISBN 10 : 9811520178
Pages : 250 pages

This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

A Practical Approach to the Care of Adolescents and Young Adults with Cancer
Author : Julia Chisholm,Rachael Hough,Louise Soanes
Publisher : Springer
Release Date : 2018-02-27
ISBN 10 : 3319661736
Pages : 260 pages

This book discusses the most important practical aspects involved in providing multidisciplinary Adolescent and Young Adult (AYA) services for cancer patients. It draws on international experience in several continents of establishing and running such services and provides a contemporary, practical approach to AYA care based on accumulated experience. It is of interest to those establishing or seeking to improve AYA services as well as those already caring for AYA cance patients. Among topics discussed are incidence trends and treatment pathways, access to clinical trials for adolescents, transition from pediatric to adult services, psychological support and social care as well as survivorship and fertility. This book is of value of those establishing new services, those developing an existing service and those whose work includes the care of AYA patients. It is an important companion for pediatricians, oncologists as well as other medical, nursing and allied health professionals caring for Adolescents and Yound Adults with cancer.

Immune Response Activation
Author : Guy Huynh Thien Duc
Publisher : BoD – Books on Demand
Release Date : 2014-05-29
ISBN 10 : 9535113747
Pages : 276 pages

The book Immune Response Activation is aiming to analyse the multifaceted aspects of the immune response, treating a number of representative cases in which the immune response is, on one hand, activated against pathogens, and, on the other hand, involved in pathologic settings, leading to allograft rejection, allergy and autoimmunity. The regulatory mechanisms in which the immune response can be modulated for rendering its effector components more efficient and/or not harmful to the organism is also dissected in translational purposes in cancer immunotherapy, local immunity against bacteria and viruses, as well as in allergy and autoimmunity.

Cancer Immunology
Author : Nima Rezaei
Publisher : Springer
Release Date : 2015-04-24
ISBN 10 : 3662464101
Pages : 488 pages

Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tumors and breast cancers. In so doing, it builds on the previous two volumes in Cancer Immunology, placing basic knowledge on tumor immunology and immunotherapy into a clinical perspective with the aim of educating clinicians on advances in cancer immunology and the most recent approaches in the immunotherapy of various tumors. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.