biophysical mass spectrometry

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Mass Spectrometry in Biophysics
Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Release Date : 2005-05-06
ISBN 10 : 0471705160
Pages : 320 pages
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The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.

Mass Spectrometry in Structural Biology and Biophysics
Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Release Date : 2012-04-03
ISBN 10 : 0470937793
Pages : 289 pages
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With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and a brief overview of traditional biophysical techniques before outlining the more advanced concepts of mass spectrometry. The new edition gives an up-to-date and expanded coverage of experimental methodologies and a clear look at MS-based methods for studying higher order structures and biopolymers. A must for researchers in the field of biophysics, structural biology, and protein chemistry.

Biophysical Techniques in Drug Discovery
Author : Angeles Canales
Publisher : Royal Society of Chemistry
Release Date : 2017-11-14
ISBN 10 : 1788012860
Pages : 320 pages
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Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
Author : Damian J. Houde,Steven A. Berkowitz
Publisher : Newnes
Release Date : 2014-09-05
ISBN 10 : 0444595902
Pages : 426 pages
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Biophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly employed in the biopharmaceutical industry today as well as up and coming promising methods that are now gaining increasing attention. As a general resource guide this book has been written with the intent to help today’s industrial scientists working in the biopharmaceutical industry or the scientists of tomorrow who are planning a career in this industry on how to successfully implement these biophysical methodologies. In so doing a keen focus is placed on understanding the capability of these methodologies in terms of what information they can deliver. Aspects of how to best acquire this biophysical information on these very complex drug molecules, while avoiding potential pitfalls, in order to make concise, well informed productive decisions about their development are key points that are also covered. Presents the reader with a clear understanding of the real world issues and challenges in using these methods. Highlights the capabilities and limitations of each method. Discusses how to best analyze the data generated from these methods. Points out what one needs to look for to avoid making faulty conclusions and mistakes. In total it provides a check list or road map that empowers the industrial scientists as to what they need to be concerned with in order to effectively do their part in successfully developing these new drugs in an efficient and cost effective manner.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
Author : Damian J. Houde,Steven A. Berkowitz
Publisher : Elsevier
Release Date : 2019-11-13
ISBN 10 : 0444641742
Pages : 586 pages
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Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data. Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development Highlights the capabilities and limitations of each technique Discusses the underlining science of each tool Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry

Biophysical Methods for Biotherapeutics
Author : Tapan K. Das
Publisher : John Wiley & Sons
Release Date : 2014-02-27
ISBN 10 : 1118354680
Pages : 376 pages
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With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

Biophysical Techniques
Author : Iain Campbell
Publisher : Oxford University Press
Release Date : 2012-02-16
ISBN 10 : 0199642141
Pages : 353 pages
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Biophysical Techniques explains in a readily-accessible way the basics of the various biophysical methods available so students can understand the principles behind the different methods used, and begin to appreciate which tools can be used to probe different biological questions, and the pros and cons of each.

Methods in Modern Biophysics
Author : Bengt Nölting
Publisher : Springer Science & Business Media
Release Date : 2013-03-09
ISBN 10 : 3662053675
Pages : 254 pages
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Incorporating dramatic recent advances, "Methods in Modern Biophysics" presents a fresh and timely introduction to modern biophysical methods. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, and proteomics. Containing much information previously unavailable in tutorial form, "Methods in Modern Biophysics" employs worked examples and more than 260 illustrations to fully detail the techniques and their underlying mechanisms. The book was written for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in biophysics, biochemistry, general biology and related fields.

Introduction to Biophysical Methods for Protein and Nucleic Acid Research
Author : Jay A. Glasel,Murray P. Deutscher
Publisher : Academic Press
Release Date : 1995-11-20
ISBN 10 : 9780080534985
Pages : 510 pages
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The first of its kind, Introduction to Biophysical Methods for Protein and Nucleic Acid Research serves as a text for the experienced researcher and student requiring an introduction to the field. Each chapter presents a description of the physical basis of the method, the type of information that may be obtained with the method, how data should be analyzed and interpreted and, where appropriate, practical tips about procedures and equipment. Key Features * Modern Use of Mass Spectroscopy * NMR Spectroscopy * Molecular Modeling and Graphics * Macintosh and DOS/Windows 3.x disks

Biomedical Applications of Biophysics
Author : Thomas Jue
Publisher : Springer Science & Business Media
Release Date : 2010-08-18
ISBN 10 : 9781603272339
Pages : 237 pages
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In keeping with goal and style of the Handbook in Modern Biophysics series, the proposed book will maintain a chapter structure that contains two parts: concepts and biological application. The book also integrates all the chapters into a smooth, continuous discourse. The first and second chapters establish the mathematical methods and theoretical framework underpinning the different topics in the rest if the book. Other chapters will use the theoretical framework as a basis to discuss optical and NMR approaches. Each chapter will contain innovative didactic elements that facilitate teaching, self-study, and research preparation (key points, summary, exercise, references).

Methods in Molecular Biophysics
Author : Nathan R. Zaccai,Igor N. Serdyuk,Joseph Zaccai
Publisher : Cambridge University Press
Release Date : 2017-05-18
ISBN 10 : 1107056373
Pages : 702 pages
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A comprehensive graduate textbook explaining key physical methods in biology, reflecting the very latest research in this fast-moving field.

Applied Biophysics for Drug Discovery
Author : Donald Huddler,Edward R. Zartler
Publisher : John Wiley & Sons
Release Date : 2017-10-02
ISBN 10 : 111909948X
Pages : 312 pages
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13.2.1 Protein Dynamics of SA WT and S1 Mutant DHFR in Apo and Bound States

Modern Biophysical Chemistry
Author : Peter Jomo Walla
Publisher : John Wiley & Sons
Release Date : 2015-09-10
ISBN 10 : 3527683550
Pages : 360 pages
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This updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooks

Biophysical Chemistry
Author : Alan Cooper
Publisher : Royal Society of Chemistry
Release Date : 2004
ISBN 10 : 9780854044801
Pages : 184 pages
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This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study.

Biophysical Techniques in Photosynthesis
Author : Thijs Aartsma,Jörg Matysik
Publisher : Springer Science & Business Media
Release Date : 2008-02-01
ISBN 10 : 1402082509
Pages : 520 pages
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Since the first volume on Biophysical Techniques in Photosynthesis Research, published in 1996, new experimental techniques and methods have been devised at a rapid pace. The present book is a sequel which complements the publication of the first volume by providing a comprehensive overview of the most important new techniques developed over the past ten years, especially those that are relevant for research on the mechanism and fundamental aspects of photosynthesis.

Introduction to Biophysical Methods for Protein and Nucleic Acid Research
Author : Jay A. Glasel,Murray P. Deutscher
Publisher : Academic Press
Release Date : 1995-11-20
ISBN 10 : 9780080534985
Pages : 510 pages
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The first of its kind, Introduction to Biophysical Methods for Protein and Nucleic Acid Research serves as a text for the experienced researcher and student requiring an introduction to the field. Each chapter presents a description of the physical basis of the method, the type of information that may be obtained with the method, how data should be analyzed and interpreted and, where appropriate, practical tips about procedures and equipment. Key Features * Modern Use of Mass Spectroscopy * NMR Spectroscopy * Molecular Modeling and Graphics * Macintosh and DOS/Windows 3.x disks

Annual Review of Biophysics and Biophysical Chemistry
Author : N.A
Publisher : N.A
Release Date : 1989
ISBN 10 :
Pages : 329 pages
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Annual Review of Biophysics and Biophysical Chemistry
Author : Donald M. Engelman,Charles R. Cantor
Publisher : N.A
Release Date : 1991-06
ISBN 10 : 9780824318208
Pages : 620 pages
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Biophysical Approaches Determining Ligand Binding to Biomolecular Targets
Author : Alberto Podjarny,Annick P Dejaegere,Bruno Kieffer
Publisher : Royal Society of Chemistry
Release Date : 2011-04-01
ISBN 10 : 1849732663
Pages : 260 pages
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The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design. This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness. This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available.

Experimental Methods in Biophysical Chemistry
Author : Claude Nicolau
Publisher : John Wiley & Sons
Release Date : 1973
ISBN 10 :
Pages : 687 pages
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