biomechanics of coronary atherosclerotic plaque

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Biomechanics of Coronary Atherosclerotic Plaque
Author : N.A
Publisher : Academic Press
Release Date : 2020-03-15
ISBN 10 : 0128171960
Pages : 686 pages
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Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, Fourth Edition summarizes all biomechanical aspects of each living organ in one comprehensive reference. The first two volumes introduce Continuum Fluid and Solid Biomechanics approaches, with each subsequent volume covering the important biomechanical and clinical aspects. The key thought leaders in the field of Biomechanics of Living Organs have gathered together their expertise in this series, making it an essential reference for anyone working in this research area. This book presents the first such resource to cover fluid and solid biomechanical studies conducted in this last decade to increase our understanding of plaque initiation, growth and rupture and improve the design of medical devices and clinical interventions, including surgical procedures. Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations Highlights the correlation between plaque initiation regions and blood shear stress amplitude Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)

Biomechanics of Living Organs
Author : Yohan Payan,Jacques Ohayon
Publisher : World Bank Publications
Release Date : 2017-05-01
ISBN 10 : 0128040602
Pages : 400 pages
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Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling is the first book to cover finite element biomechanical modeling of each organ in the human body. This collection of chapters from the leaders in the field focuses on the constitutive laws for each organ. Each author introduces the state-of-the-art concerning constitutive laws and then illustrates the implementation of such laws with Finite Element Modeling of these organs. The focus of each chapter is on instruction, careful derivation and presentation of formulae, and methods. When modeling tissues, this book will help users determine modeling parameters and the variability for particular populations. Chapters highlight important experimental techniques needed to inform, motivate, and validate the choice of strain energy function or the constitutive model. Remodeling, growth, and damage are all covered, as is the relationship of constitutive relationships of organs to tissue and molecular scale properties (as net organ behavior depends fundamentally on its sub components). This book is intended for professionals, academics, and students in tissue and continuum biomechanics. Covers hyper elastic frameworks for large tissue deformations Considers which strain energy functions are the most appropriate to model the passive and active states of living tissue Evaluates the physical meaning of proposed energy functions

Atherosclerotic Plaque Characterization Methods Based on Coronary Imaging
Author : Lambros S Athanasiou,Dimitrios I Fotiadis,Lampros K Michalis
Publisher : Academic Press
Release Date : 2017-05-04
ISBN 10 : 0128051132
Pages : 234 pages
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Atherosclerotic Plaque Characterization Methods Based on Coronary Imaging provides a complete review of computer methods for atherosclerotic plaque reconstruction and characterization. The authors, with their expertise from biomedical engineering, computer science, and cardiology, offer a holistic view. The focus of the book is on the presentation of major imaging techniques, including their limitations. It includes details on the mechanical characterization and properties of plaques and appropriate constitutive models to describe the mechanical behavior of plaques. The authors explore the challenges of using multiple coronary imaging technologies, and provide the pros and cons of invasive vs. non-invasive techniques. Methods for plaque characterization and 3D reconstruction of coronary arteries using IVUS, OCT, and CT images are described. This book will help readers study new trends in image processing analysis and plaque characterization, implement automated plaque characterization methodologies, understand coronary imaging drawbacks, and comprehend 3 dimensional coronary artery and plaque reconstruction methods. Describes the multimodality imaging techniques that are commonly used in the diagnosis of arterial diseases, including intravascular ultrasound, optical coherence tomography, angiography, computed tomography angiography, and magnetic resonance angiography Discusses in-depth the computational methods which can be used for the detection of different plaque types Explores plaque in 3D reconstruction methods and plaque modeling approaches

Plaque Imaging
Author : Jasjit S. Suri
Publisher : IOS Press
Release Date : 2005-01-01
ISBN 10 : 1586035169
Pages : 461 pages
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This publication starts of with a review of plaque imaging techniques, with an introduction of the segmentation techniques for plaque classification and quantification. Many aspects of plaque imaging techniques are presented in this publication, such as; medical image retrieval and database management, MRI techniques to differentiate stable versus high risk atherosclerosis, composition and morphology of atherosclerotic plaque, analysis of the soft tissue based on computer vision techniques, modelling of coronary artery biomechanics, Cardiac CT for the assessment of cardiovascular pathology with an emphasis on the detection of coronary atherosclerosis, technical and practical issues regarding coronary atherosclerotic plaque imaging by CT (focussing on coronary calcium imaging), feasibility of a non-invasive, in vivo determination of the IBS of arterial wall tissue, high resolution ultrasound images of carotid plaques, the problem of reliable features extraction and classification process and a discussion on advanced mathematical techniques to extract spectral information from the RF data to determine the plaque composition.

Computational Biomechanics for Medicine
Author : Adam Wittek,Grand Joldes,Poul M.F. Nielsen,Barry J. Doyle,Karol Miller
Publisher : Springer
Release Date : 2017-06-02
ISBN 10 : 3319544810
Pages : 173 pages
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This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics; injury biomechanics; biomechanics of heart and vascular system; medical image analysis; and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, the Computational Biomechanics for Medicine series of titles provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements.

Atherosclerotic Plaque Characterization Methods Based on Coronary Imaging
Author : Lambros S Athanasiou,Dimitrios I Fotiadis,Lampros K Michalis
Publisher : Academic Press
Release Date : 2017-05-04
ISBN 10 : 0128051132
Pages : 234 pages
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Atherosclerotic Plaque Characterization Methods Based on Coronary Imaging provides a complete review of computer methods for atherosclerotic plaque reconstruction and characterization. The authors, with their expertise from biomedical engineering, computer science, and cardiology, offer a holistic view. The focus of the book is on the presentation of major imaging techniques, including their limitations. It includes details on the mechanical characterization and properties of plaques and appropriate constitutive models to describe the mechanical behavior of plaques. The authors explore the challenges of using multiple coronary imaging technologies, and provide the pros and cons of invasive vs. non-invasive techniques. Methods for plaque characterization and 3D reconstruction of coronary arteries using IVUS, OCT, and CT images are described. This book will help readers study new trends in image processing analysis and plaque characterization, implement automated plaque characterization methodologies, understand coronary imaging drawbacks, and comprehend 3 dimensional coronary artery and plaque reconstruction methods. Describes the multimodality imaging techniques that are commonly used in the diagnosis of arterial diseases, including intravascular ultrasound, optical coherence tomography, angiography, computed tomography angiography, and magnetic resonance angiography Discusses in-depth the computational methods which can be used for the detection of different plaque types Explores plaque in 3D reconstruction methods and plaque modeling approaches

Biomechanics: Trends in Modeling and Simulation
Author : Gerhard A. Holzapfel,Ray W. Ogden
Publisher : Springer
Release Date : 2016-09-14
ISBN 10 : 3319414755
Pages : 316 pages
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The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.

Abstract: Objectives: Coronary atherosclerotic plaques progress in a highly individual manner. Accurately predicting plaque progression will promote clinical management of atherosclerosis. The purpose of this study was to investigate the role of local biomechanics factors and vascular characteristics in coronary plaque progression and arterial remodeling. Methods: Computed tomography angiography-based three-dimensional reconstruction of the native right coronary artery was performed in vivo in twelve patients with acute coronary syndrome at baseline and 12-month follow-up. The reconstructed arteries were divided into sequential 3-mm-long segments. Wall shear stress (WSS) and von Mises stress (VMS) were computed in all segments at baseline by applying fluid-structure interaction simulations. Results: In total, 365 segments 3-mm long were analyzed. The decrease in minimal lumen area was independently predicted by low baseline VMS (−0.73 ± 0.13 mm 2 ), increase in plaque burden was independently predicted by small minimal lumen area and low baseline WSS (6.28 ± 0.96%), and decrease in plaque volume was independently predicted by low baseline VMS (−0.99 ± 0.49 mm 3 ). Negative remodeling was more likely to occur in low- (55%) and moderate-VMS (40%) segments, but expansive remodeling was more likely to occur in high-VMS (44%) segments. Conclusions: Local von Mises stress, wall shear stress, minimal lumen area, and plaque burden provide independent and additive prediction in identifying coronary plaque progression and arterial remodeling.

Multi-Modality Atherosclerosis Imaging and Diagnosis
Author : Luca Saba,João Miguel Sanches,Luís Mendes Pedro,Jasjit S. Suri
Publisher : Springer Science & Business Media
Release Date : 2013-09-13
ISBN 10 : 1461474256
Pages : 422 pages
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Stroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. Understanding why and how plaque develops and ruptures requires a multi-disciplinary approach such as radiology, biomedical engineering, medical physics, software engineering, hardware engineering, pathological and histological imaging. Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment presents a new dimension of understanding Atherosclerosis in 2D and 3D. This book presents work on plaque stress analysis in order to provide a general framework of computational modeling with atherosclerosis plaques. New algorithms based on 3D and 4D Ultrasound are presented to assess the atherosclerotic disease as well as very recent advances in plaque multimodality image fusion analysis. The goal of Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment is to fuse information obtained from different 3D medical image modalities, such as 3D US, CT and MRI, providing the medical doctor with some sort of augmented reality information about the atherosclerotic plaque in order to improve the accuracy of the diagnosis. Analysis of the plaque dynamics along the cardiac cycle is also a valuable indicator for plaque instability assessment and therefore for risk stratification. 4D Ultrasound, a sequence of 3D reconstructions of the region of interest along the time, can be used for this dynamic analysis. Multimodality Image Fusion is a very appealing approach because it puts together the best characteristics of each modality, such as, the high temporal resolution of US and the high spatial resolutions of MRI and CT.

Coronary Artery Disease
Author : Dimitris Tousoulis
Publisher : Academic Press
Release Date : 2017-10-01
ISBN 10 : 9780128119082
Pages : 512 pages
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Coronary Artery Disease: From Biology to Clinical Practice links the most important basic concepts of atherosclerosis pathophysiology to treatment management of Coronary Artery Disease. Comprehensive coverage starts with the basic pathophysiologic mechanisms of the disease including molecular and genetic mechanisms, cells interaction, and inflammation. Coverage also includes novel anti-atherosclerotic therapies and a thorough understanding of the recent trends in clinical management. By summarizing this novel knowledge and changes in diagnostic algorithm and treatment options, this is the perfect reference for cardiology researchers who want a volume with the most up-to-date experimental trends in the field of atherosclerosis; cardiologists and physicians who manage patients with atherosclerotic risk factors and established coronary artery disease; and medical students who want to learn the basic concepts of atherosclerosis. Delivers a comprehensive connection between basic pathophysiologic mechanisms and the clinical context of coronary artery disease Provides a focus on the most important novel evidence in the management of atherosclerosis and coronary artery disease Includes sum-up tables at the end of each chapter as well as clinical scenarios focusing on diagnosis and treatment to aid in faster reference of important concepts Conveys an understanding of upcoming novel experimental and clinical treatments

Cardiovascular Biomechanics
Author : Peter R. Hoskins,Patricia V. Lawford,Barry J. Doyle
Publisher : Springer
Release Date : 2017-02-16
ISBN 10 : 3319464078
Pages : 462 pages
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This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.

ESC Textbook of Vascular Biology
Author : Robert Krams,Magnus Bäck
Publisher : Oxford University Press
Release Date : 2017-02-09
ISBN 10 : 0198755775
Pages : 352 pages
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Atherosclerosis is the most significant cause of cardiovascular disease worldwide. Vascular biology is the key to understanding how atherosclerosis arises and operates. The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research. The textbook covers molecular findings and novel targets within the speciality while also providing the basics of vascular biology and disease pathophysiology. It also covers the major changes in the diagnosis, prevention and treatment of atherosclerosis that have occurred in recent years, developments and recent breakthroughs in the field are specifically highlighted. The official publication of the ESC Working Group on Arthrosclerosis and Vascular Biology, this print edition comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. The textbook is also linked to the ESC's online learning platform (ESCel) and their core specialist training curriculum (ESC Core Curriculum). The textbook particularly appeals to vascular biologists, cardiologists, and other practising clinicians.

Atherosclerosis
Author : Luigi Gianturco
Publisher : BoD – Books on Demand
Release Date : 2018-08-01
ISBN 10 : 178923560X
Pages : 128 pages
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Atherosclerosis is a subject of enormous contention for cardiologists and in general for all medical doctors. With this publication we have given you a concise "state-of-the-art" look at the world of atheroma. Many other elements could be included and so it is only a brief analysis of "today" (the preventive medicine era) and "tomorrow" (transforming the cure medicine era into the care medicine era) but also remembering "yesterday" (the ex-cathedra medicine era). Let's hope our arteries are free from atherosclerotic events: have a good read!

Intravascular Ultrasound
Author : Simone Balocco
Publisher : Elsevier
Release Date : 2020-06-06
ISBN 10 : 0128188340
Pages : 218 pages
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Intravascular Ultrasound: From Acquisition to Advanced Quantitative Analysis covers topics of the whole imaging pipeline, ranging from the definition of the clinical problem and image acquisition systems to image processing and analysis, including the assisted clinical-decision making procedures and treatment planning (stent deployment and follow up). Atherosclerosis, a disease of the vessel wall that produces vessel narrowing and obstruction, is the major cause of cardiovascular diseases, such as heart attack or stroke. This book covers all aspects of this imaging tool that allows for the visualization of internal vessel structures and the quantification and characterization of coronary plaque. Provides an introduction to the clinical workflow and current challenges in endovascular interventions Presents a review of the state-of-the-art methodologies in IVUS imaging and their applications Includes a rich analysis of the current and potential future connections between the academic, clinical and industrial fields

Sudden Coronary Death
Author : Henry M. Greenberg,Edward M. Dwyer
Publisher : N.A
Release Date : 1982
ISBN 10 : 9780897661539
Pages : 484 pages
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Biomechanical Characterization of Atherosclerotic Plaques
Author : Donna Michelle Ebenstein
Publisher : N.A
Release Date : 2002
ISBN 10 :
Pages : 762 pages
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PanVascular Medicine
Author : Peter Lanzer
Publisher : Springer
Release Date : 2015-03-30
ISBN 10 : 9783642370779
Pages : 5004 pages
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​Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

Bifurcation Stenting
Author : Ron Waksman,John A. Ormiston
Publisher : John Wiley & Sons
Release Date : 2012-03-22
ISBN 10 : 1444346989
Pages : 304 pages
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Here is expert guidance on one of the most vexing clinical challenges faced by interventional cardiologists. Written by global thought leaders in the area and edited by two internationally-recognized pioneers in interventional cardiology, Bifurcation Stenting covers all techniques, imaging modalities, and devices in current use, including VH-IVUS and OCT. It includes practical tips/tricks from leading experts and a section of challenging cases to further illustrate the material and help readers better understand the treatment of bifurcation lesions.

Computational Biomechanics for Medicine
Author : Barry Doyle,Karol Miller,Adam Wittek,Poul M.F. Nielsen
Publisher : Springer
Release Date : 2014-05-24
ISBN 10 : 149390745X
Pages : 122 pages
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One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences and medicine. The Computational Biomechanics for Medicine series provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This 5th edition comprises nine of the latest developments in both fundamental science and patient-specific applications, from researchers in Australia, New Zealand, USA, UK, France, Ireland and China. Some of the interesting topics discussed are: cellular mechanics; tumor growth and modeling; medical image analysis and both patient-specific fluid dynamics and solid mechanic simulations.

The Vulnerable Atherosclerotic Plaque
Author : Renu Virmani,Jagat Narula,Martin B. Leon,James T. Willerson
Publisher : John Wiley & Sons
Release Date : 2008-04-15
ISBN 10 : 0470987332
Pages : 384 pages
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Finally, a convenient, one-volume summary of current knowledge on an area of increasing importance! The Vulnerable Atherosclerotic Plaque presents contributions from the best investigators in the field, skillfully edited for easy reading and lavishly illustrated with high-quality, full-color images. After a considered and concise introduction, the book concentrates on: Pathology of vulnerable plaque Triggers for plaque rupture Imaging of unstable plaque Management of vulnerable plaques Careful editing allows the authors to avoid repetition and provide comprehensive coverage of pathology, detection, and management. This thorough and authoritative reference will change the way interventionists look at the disease.