Biomaterials for Skin Repair and Regeneration examines a range of materials and technologies used for regenerating or repairing skin. With a strong focus on biomaterials and scaffolds, the book also examines the testing and evaluation pathway for human clinical trials. Beginning by introducing the fundamentals on skin tissue, the book goes on to describe contemporary technology used in skin repair as well as currently available biomaterials suitable for skin tissue repair and regeneration. Skin tissue engineering and the ideal requirements to take into account when developing skin biomaterials are discussed, followed by information on the individual materials used for skin repair and regeneration. As evaluation of biomaterials in animal models is mandatory before proceeding into human clinical trials, the book also examines the different animal models available. With a strong focus on materials, engineering, and application, this book is a valuable resource for materials scientists, skin biologists, and bioengineers with an interest in tissue engineering, regeneration, and repair of skin. Provides an understanding of basic skin biology Comprehensively examines a variety of biomaterial approaches Looks at animal models for the evaluation of biomaterial-based skin constructs
Researchers working on developing biomaterials for skin regeneration need an understanding of the basics of skin tissue and the different types of materials used to develop scaffolds. This book provides biomaterial scientists working on skin with the ability to check facts on biomaterial properties which they can use to develop skin regeneration technologies. Provides an understanding of basic skin biology Comprehensively examines a variety of biomaterial approaches Looks at animal models for evaluating of biomaterial-based skin constructs
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. Explores cellular and molecular processes of wound healing, scar formation, and dermal repair Includes examples of animal models for wound healing and translation to the clinical world Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies
The primary causes of wounds requiring skin replacement are severe burns and ulcers. Materials must provide an effective temporary barrier, promote healing and minimise scarring. Massive improvements have been made to skin repair biomaterials in the last ten years with widespread adoption of new developments in the medical sector. This book provides a comprehensive review of the range of biomaterials for treating skin loss. Part one discusses the basics of skin replacement with chapters on such topics as markets and regulation, biomechanics and the biological environment of skin. Part two then reviews epidermal and dermal replacement technology with chapters on such topics as alternative delivery of keratinocytes, collagen-based and human origin-based dermal replacement, and lyophilized xenogenic products. The final section explores combined dermis and epidermal replacement technologies and provides a round-up of skin replacement principles. With its distinguished editors and international team of contributors, Biomaterials for treating skin loss is a standard reference for those researching skin replacement technologies, particularly those interested in treating burns and ulcers. Comprehensively reviews the range of biomaterials for treating skin loss and skin replacement principles Examines the basis of skin loss from products and markets through to regulation and the biological environment of skin Highlights developments in epidermal and dermal replacement technology covering topics such as collagen-based and human origin-based dermal replacement
Wound Healing Biomaterials: Volume One, Therapies and Regeneration discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal these types of wounds, with science increasingly turning towards biomaterials to address these challenges. Much research is now concerned with new therapies, regeneration methods, and biomaterials to assist in wound healing and healing response. This book provides readers with a comprehensive review of the fundamentals and advances in the field of wound healing with regard to therapies and tissue regeneration. Chapters in Part One discuss fundamentals and strategies of wound healing, while Part Two reviews gene, stem cell, and drug delivery therapies for wound healing. Final chapters look at tissue regeneration strategies, making this an all-encompassing book on the topic of wound care and biomaterials. Provides more systematic and comprehensive coverage of specific therapies and biomaterials for wound healing Highlights research that is concerned with new therapies, regeneration methods, and the use of biomaterials to assist in wound healing and healing response Presents an organized layout of the material that is carefully arranged with clear titles and comprehensive section headings Looks at tissue regeneration strategies, making this an all encompassing book on the topic of wound care
|Author||: Rakesh Sharma|
|Publisher||: BoD – Books on Demand|
|Release Date||: 2018-05-02|
|ISBN 10||: 1789230101|
|Pages||: 352 pages|
Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.
|Author||: Mario Barbosa,M Cristina L Martins|
|Publisher||: Woodhead Publishing|
|Release Date||: 2017-09-25|
|ISBN 10||: 008100852X|
|Pages||: 390 pages|
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers
A comprehensive review of the range of biomaterials for treating skin loss, this book begins with a discussion of the basics of skin replacement with chapters on topics such as markets and regulation, biomechanics and the biological environment of skin. It then reviews epidermal and dermal replacement technology, discussing the alternative delivery of keratinocytes, collagen-based and human origin-based dermal replacement, and lyophilized xenogenic products. The conclusion explores combined dermis and epidermal replacement technologies and provides a round-up of skin replacement principles.
|Author||: Debasis Bagchi,Amitava Das,Sashwati Roy|
|Publisher||: Academic Press|
|Release Date||: 2020-04-18|
|ISBN 10||: 012816414X|
|Pages||: 638 pages|
Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals. Explains diabetic wounds and their complications Assesses the role of nutraceuticals, herbal supplements and other modalities for use in treating diabetic wounds Provides protocols for diabetic wound management
Wound Healing Biomaterials: Volume Two, Functional Biomaterials discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal wounds opening up a new area of research in biomaterials and the ways they can be applied to the challenges associated with wound care. Much research is now concerned with new therapies, regeneration methods, and the use of biomaterials that can assist in wound healing and alter healing responses. This book provides readers with a thorough review of the functional biomaterials used for wound healing, with chapters discussing the fundamentals of wound healing biomaterials, films for wound healing applications, polymer-based dressing for wound healing applications, and functional dressings for wound care. Includes more systematic and comprehensive coverage on the topic of wound care Provides thorough coverage of all specific therapies and biomaterials for wound healing Contains clear layout and organization that is carefully arranged with clear titles and comprehensive section headings Details specific sections on the fundamentals of wound healing biomaterials, films for wound healing applications, polymer-based dressing for wound healing applications, and more
Outstanding scientific advances over the last decades unceasingly reveal real complexity of wound-healing process, astonishing in its staged progression, as life is unfolding itself. This natural course of tissue repair seems to bear thousands of overlapping molecular and macroscopic processes that nowadays only start to unfold to our knowledge. The present volume collecting recent scientific references proposes to readers a two-folded audacious goal. First, an updated design of intimate cellular mechanisms is entailed in tissue regeneration that emanates from the first section of the book. Next, a multidisciplinary therapeutic perspective that focuses on macroscopic healing throughout the second part of this work adds clinically integrated observation. Practical diagnostic and treatment information is appended in each chapter that may equally help experienced clinicians or dedicated students and researchers in broadening essential breaking points of their work. It is the wish of all multidisciplinary experts who gather prominent author's panel of this volume to incorporate latest medical reports and compel limits of current understanding for better tissue regeneration, limb salvage, and improved quality of life of our patients.
Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).
A comprehensive resource on the recent developments of stem cell use in wound healing With contributions from experts in the field, Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds. Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource: Provides a comprehensive overview of stem cell use in wound healing, including both the basic and translational aspects of the field Covers recent developments and emerging subtopics within the field Offers an invaluable resource to clinical and basic researchers who are interested in wound healing, stem cells, and regenerative medicine Contains contributions from leading experts in the field of wound healing and care Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.
|Author||: Subhas Kundu|
|Release Date||: 2014-03-24|
|ISBN 10||: 0857097067|
|Pages||: 582 pages|
Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering. Discusses the properties and applications of silk for medical purposes Considers pharmaceutical and cosmeceutical applications
|Author||: Charles Archer,Jim Ralphs|
|Release Date||: 2010-01-12|
|ISBN 10||: 1845697790|
|Pages||: 504 pages|
Regenerative medicine for the repair of connective tissues is a fast moving field which generates a lot of interest. Unfortunately the biomaterials and biomechanics for soft tissue repair has been under-represented in the past. Particularly the natural association between cartilage, tendons and ligaments is often not made. Regenerative medicine and biomaterials for the repair of connective tissues addresses this gap in the market by bringing together the natural association of cartilage, tendons and ligaments to provide a review of the different structures, biomechanics and, more importantly, provide a clear discussion of practical techniques and biomaterials which may be used to repair the connective tissues. Part one discusses cartilage repair and regeneration with chapters on such topics as structure, biomechanics and repair of cartilage. Chapters in Part two focus on the repair of tendons on ligaments with particular techniques including cell-based therapies for the repair and regeneration of tendons and ligaments and scaffolds for tendon and ligament tissue engineering. Addresses the natural association between cartilage, tendons and ligaments which is often not made Provides a review of the different structures, biomechanics and practical techniques which are used in the repair of connective tissues Chapters focus on such areas as cartilage repair and regeneration, the repair of tendons and ligaments, investigating techniques including scaffolds and cell-based therapies
|Author||: Masoud Mozafari,Jayakumar Rajadas,David Kaplan|
|Release Date||: 2018-09-28|
|ISBN 10||: 9780128133552|
|Pages||: 512 pages|
Nanoengineered Biomaterials for Regenerative Medicine showcases the advances that have taken place in recent years as an increasing number of nanoengineered biomaterials have been targeted to various organ tissues. The book systematically explores how nanoengineered biomaterials are used in different aspects of regenerative medicine, including bone regeneration, brain tissue reconstruction and kidney repair. It is a valuable reference resource for scientists working in biomaterials science who want to learn more about how nanoengineered materials are practically applied in regenerative medicine. Nanoengineered biomaterials have gained particular focus due to their many advantages over conventional techniques for tissue repair. As a wide range of biomaterials and nanotechnology techniques have been examined for the regeneration of tissues, this book highlights the discussions and advancements made. Provides a digestible reference source for surgeons and physicians who want to learn more on nanoengineered biomaterials and their use in effective medical treatments Offers systematic coverage on how nanoengineered biomaterials are used for different types of medicine Assesses the benefits and drawbacks of the use of bioengineered nanomaterials in different areas of regenerative medicine
A significant proportion of modern medical technology has been developed through biomimetics, which is biologically inspired by studying pre-existing functioning systems in nature. Typical biomimetically inspired biomaterials include nano-biomaterials, smart biomaterials, hybrid biomaterials, nano-biocomposites, hierarchically porous biomaterials and tissue scaffolds. This important book summarises key research in this important field. The book is divided into two parts: Part one is devoted to the biomimetics of biomaterials themselves while part two provides overviews and case studies of tissue engineering applications from a biomimetics' perspective. The book has a strong focus on cutting edge biomimetically inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings. Since many scaffolds for skin tissue engineering are biomimetically inspired, the book also has a strong focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs. With its distinguished editor and international team of contributors, Biomimetic biomaterials is a standard reference for both the biomaterials research community and clinicians involved in such areas as bone regeneration, skin tissue and wound repair. Places strong focus on cutting edge biomimetically-inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings Provides overviews and case studies of tissue engineering applications from a biomimetics perspective Also places focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs
This book serves as a good starting point for anyone interested in the application of tissue engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications. The first part covers the use of adult stem cells and their applications. The following chapters offer an insight into the development of a tailored biomaterial for organ replacement and highlight the importance of cell-biomaterial interaction. In summary, this book offers insights into a wide variety of cells, biomaterials, interfaces and applications of the next generation biotechnology, which is tissue engineering.
Electrospinning is a simple and highly versatile method for generating ultrathin fibres with diameters ranging from a few micrometres to tens of nanometres. Although most commonly associated with textile manufacturing, recent research has proved that the electrospinning technology can be used to create organ components and repair damaged tissues. Electrospinning for tissue regeneration provides a comprehensive overview of this innovative approach to tissue repair and regeneration and examines how it is being employed within the biomaterials sector. The book opens with an introduction to the fundamentals of electrospinning. Chapters go on to discuss polymer chemistry, the electrospinning process, conditions, control and regulatory issues. Part two focuses specifically on electrospinning for tissue regeneration and investigates its uses in bone, cartilage, muscle, tendon, nerve, heart valve, bladder, tracheal, dental and skin tissue regeneration before concluding with a chapter on wound dressings. Part three explores electrospinning for in vitro applications. Chapters discuss cell culture systems for kidney, pancreatic and stem cell research. With its distinguished editors and international team of expert contributors, Electrospinning for tissue regeneration is a valuable reference tool for those in academia and industry concerned with research and development in the field of tissue repair and regeneration. Provides a comprehensive overview of this innovative approach to tissue repair and regeneration covering issues from polymer chemistry to the regulatory process Examines employment within the biomaterials sector, reviewing extensive applications in areas such as uses in bone, muscle tendon, heart valve and tissue regeneration Explores electrospinning for in vitro applications and discusses cell culture systems for kidney, pancreatic and stem cell research
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs