This book deals with a subject of high interest and importance in all sectors, including biomedical, food, agriculture, energy, and environment. Biological systems are essential in nanotechnology, and many new applications are being developed by mimicking the natural systems. Approaching these topics from an engineering perspective, the book offers insight on the details of nanoscale fabrication processes as well as cell biology. The basics of biology and chemistry, with a focus on how to engineer the behavior of molecules at the nanoscale, are also explored and analyzed. The aim of the text is to provide the reader with broader knowledge of biological methods for signal transduction and molecular recognitions systems and how they can be replicated in bio-sensing applications. The reader will learn the basic structures and interactions of biomacromolecules for developing biocompatible and eco-friendly devices.
A comprehensive introduction to nano- and biomaterials shining light on the different research disciplines from various perspectives. The straightforward and well-structured concept is designed to cater for entrants as well as experienced researchers in the field of nanotechnology. The initial chapters introduce nanomaterials, their classification and synthesis techniques, while subsequent chapters discuss the various characterization tools as well as mechanical properties and their applications in biotechnological and biomedical fields. Further understanding of the topic is supported by case studies used for practical purposes. The book concludes with a look at future technology advances. With its explanation of a wide variety of materials, this is an essential reference for chemists, physicists, materials scientists and biomedical engineers.
There is a continuous exchange of ideas taking place at the border of the biological and physical sciences in many areas of nanoscience. Nanotechnology uses biomimetic or bio-inspired processes to produce nanosized materials for applications in biology and other fields. In return, the fruits of nanotechnology are applied to expanding areas of biomedical and therapeutic processes, such as new nanostructures and scaffolds for tissue engineering or targeted drug delivery. In this way, nanobiotechnology serves as a bridge between nano and bio, with nanoscale materials providing the building blocks for the construction of the "bridge." Nanobiomaterials: Development and Applications gives you a broad, interdisciplinary view of current developments as well as new findings and applications in bionanomaterials. The book brings together the work of international contributors who are actively engaged at the forefront of research in their respective disciplines. Organized into four parts, this book explores the preparation and characterization of nanomaterials, new preparation routes of soft nanomaterials using biomolecules, nano- and microscale hybridization of materials, and nanotoxicity. The contributors cover a diverse set of topics, including: Biomimetic synthesis Bioimaging and cancer diagnosis Photodynamic therapy Bioconjugated carbon nanotube DNA transfection and tumor targeting Magnetically induced hyperthermia Cytotoxity mechanisms and their potential use in therapy Virus-enabled manufacturing of functional nanomaterials Biocatalitic nanosystems and enzyme immobilization Tissue engineering The fabrication of hybrid microswimmers Bionanomaterial applications in environmental remediation Each chapter is richly illustrated and includes an extensive list of references to guide you toward further research. Combining bionanomaterial development and applications, the book clearly demonstrates the importance of these materials to biotechnology, biomedicine, and environmental remediation. It offers an accessible overview for students, industrial researchers, pharmaceutical innovators, medical and public health personnel, environmental scientists and engineers, and anyone interested in this interdisciplinary field.
The impact and importance of nanotechnology continues to grow, and nanomedicine and biotechnology have become areas of increased development. Biomedical engineers who work with biological processes and structures must have a deeply rooted understanding of the role of bionanotechnology, a rapidly evolving sector of the nanotechnology field. Bionanot
|Author||: Alina-Maria Holban,Alexandru Grumezescu|
|Release Date||: 2019-03-22|
|ISBN 10||: 0128169109|
|Pages||: 512 pages|
Materials for Biomedical Engineering: Nanobiomaterials in Tissue Engineering highlights the impact of novel bioactive materials in both current applications and their potential in the future progress of tissue engineering and regenerative medicine. Tissue engineering is a well investigated and challenging bio-medical field, with promising perspectives to improve and support the quality of life in diseased patients. This book brings together the latest research findings regarding the design and versatility of bioactive materials and their potential in tissue engineering. In addition, recent progress in soft and hard tissue engineering is presented within the chapters of the book. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of bioactive materials in tissue engineering that can be used by researchers, engineers and academics Includes novel opportunities and ideas for developing or improving technologies in composites by companies, biomedical industries, and in related sectors Features at least 50% of references from the last 2-3 years
Until the late 20th century, computational studies of biomolecules and nanomaterials had considered the two subjects separately. A thorough presentation of state-of-the-art simulations for studying the nanoscale behavior of materials, Simulations in Nanobiotechnology discusses computational simulations of biomolecules and nanomaterials together. The book gives readers insight into not only the fundamentals of simulation-based characterizations in nanobiotechnology, but also in how to approach new and interesting problems in nanobiotechnology using basic theoretical and computational frameworks. Presenting the simulation-based nanoscale characterizations in biological science, Part 1: Describes recent efforts in MD simulation-based characterization and CG modeling of DNA and protein transport dynamics in the nanopore and nanochannel Presents recent advances made in continuum mechanics-based modeling of membrane proteins Summarizes theoretical frameworks along with atomistic simulations in single-molecule mechanics Provides the computational simulation-based mechanical characterization of protein materials Discussing advances in modeling techniques and their applications, Part 2: Describes advances in nature-inspired material design; atomistic simulation-based characterization of nanoparticles’ optical properties; and nanoparticle-based applications in therapeutics Overviews of the recent advances made in experiment and simulation-based characterizations of nanoscale adhesive properties Suggests theoretical frameworks with experimental efforts in the development of nanoresonators for future nanoscale device designs Delineates advances in theoretical and computational methods for understanding the mechanical behavior of a graphene monolayer The development of experimental apparatuses has paved the way to observing physics at the nanoscale and opened a new avenue in the fundamental understanding of the physics of various objects such as biological materials and nanomaterials. With expert contributors from around the world, this book addresses topics such as the molecular dynamics of protein translocation, coarse-grained modeling of CNT-DNA interactions, multi-scale modeling of nanowire resonator sensors, and the molecular dynamics simulation of protein mechanics. It demonstrates the broad application of models and simulations that require the use of principles from multiple academic disciplines.
There are several well-known books on the market that cover biomaterials in a general way, but none provide adequate focus on the future of and potential for actual uses of emerging nanontechnology in this burgeoning field.Biomaterials: A Nano Approach is written from a multi-disciplinary point of view that integrates aspects of materials science a
Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobio
|Author||: Iulian Antoniac|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2012-10-02|
|ISBN 10||: 1461443288|
|Pages||: 254 pages|
Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.
Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
This book introduces readers to the structure and characteristics of nanomaterials and their applications in dentistry. With currently available implant materials, the clinical failure rate varies from a few percent to over 10 percent and new materials are clearly needed. Nanomaterials offer the promise of higher strength, better bonding, less toxicity, and enhanced cytocompatibility, leading to increased tissue regeneration. Mieczyslaw Jurczyk, director of the Institute of Materials Science and Engineering at the Poznan University of Technology in Poland, has drawn from work in his laboratory and elsewhere in Poland to show that nanomaterials have important biological applications including in the stomatognathic system consisting of mouth, jaws, and associated structures. The book is written from a materials science and medical point of view and has 13 chapters and about 400 pages. The book can be divided approximately into three sections: the first five chapters introduce nanobiomaterials, the next five chapters describe their dental applications, and the last chapters describe their biocompatibility. Chapter 3 is a compendium on metallic biomaterials such as stainless steel, cobalt alloys, and titanium alloys; bioactive, bioresorbable polymers; and composites and ceramic biomaterials. The "top-down" approach to producing nanomaterials such as high-energy ballmilling and severe plastic deformation, as well as Feynman’s "bottom-up technique" of building atom by atom, are discussed in the next chapter. Subsequent chapters discuss each material in depth and point out how new architectures and properties emerge at the nanoscale. Chapter 8 is devoted to shape-memory materials, which now include not only NiTi but also polymers and magnetic materials. In order to improve bonding, nanomaterials can be used to synthesize implants with surface roughness similar to that of natural tissues. Chapter 9 is devoted to different surface treatments for Ti-based nanomaterials, such as anodic oxidation to improve the bioactivity of titanium and improve the corrosion resistance of porous titanium and its alloys. The use of carbon in various forms—nanoparticles, nanofibers, nanotubes, and thin films—is discussed next with emphasis on the microstructure and properties of these materials, their implant applications, and their interaction with subcutaneous tissues. Nanomaterials can be used in preventive dentistry and therefore can reduce the amount of dental treatment that is necessary to maintain a healthy mouth as argued in chapter 11. In a subsequent chapter, the author explains osseointegration (direct bone-to-metal interface) from a biological point of view and early tissue response. The mechanism of the interaction between the implanted materials with the cellular protein in the tissues is described. The last chapter discusses the application of new nanostructured materials in permanent and bioresorbable implants, nanosurface dental implants, and nanostructured dental composite restorative materials. This book not only focuses on nanomaterials but also on nanoengineering to achieve the best results in dentistry. It is recommended to anyone interested in nanomaterials and their applications in dental science. People with a background in materials, chemistry, physics, and biology will benefit from it.
""This book aims to provide vital information about the growing field of bionanotechnology for undergraduate and graduate students, as well as working professionals in various fields.The fundamentals of nanotechnology are covered along with several specific bionanotechnology applications, including nanobioimaging and drug delivery which is a growing $100 billions industry.The uniqueness of the field has been brought out with unparalleled lucidity; a balance between important insight into the synthetic methods of preparing stable nano-structures and medical applications-driven focus educates and informs the reader on the impact of this emerging field. Critical examination of potential threats followed by a current global outlook completes the discussion. In short, the book takes you through a journey from fundamentals to frontiers of bionanotechnology so that you can understand and make informed decisions on the impact of bionano on your career and business"--Book jacket.
Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials
|Author||: Sabu Thomas,Yves Grohens,Neethu Ninan|
|Publisher||: William Andrew|
|Release Date||: 2015-01-03|
|ISBN 10||: 0323353037|
|Pages||: 336 pages|
Tissue engineering involves seeding of cells on bio-mimicked scaffolds providing adhesive surfaces. Researchers though face a range of problems in generating tissue which can be circumvented by employing nanotechnology. It provides substrates for cell adhesion and proliferation and agents for cell growth and can be used to create nanostructures and nanoparticles to aid the engineering of different types of tissue. Written by renowned scientists from academia and industry, this book covers the recent developments, trends and innovations in the application of nanotechnologies in tissue engineering and regenerative medicine. It provides information on methodologies for designing and using biomaterials to regenerate tissue, on novel nano-textured surface features of materials (nano-structured polymers and metals e.g.) as well as on theranostics, immunology and nano-toxicology aspects. In the book also explained are fabrication techniques for production of scaffolds to a series of tissue-specific applications of scaffolds in tissue engineering for specific biomaterials and several types of tissue (such as skin bone, cartilage, vascular, cardiac, bladder and brain tissue). Furthermore, developments in nano drug delivery, gene therapy and cancer nanotechonology are described. The book helps readers to gain a working knowledge about the nanotechnology aspects of tissue engineering and will be of great use to those involved in building specific tissue substitutes in reaching their objective in a more efficient way. It is aimed for R&D and academic scientists, lab engineers, lecturers and PhD students engaged in the fields of tissue engineering or more generally regenerative medicine, nanomedicine, medical devices, nanofabrication, biofabrication, nano- and biomaterials and biomedical engineering. Provides state-of-the-art knowledge on how nanotechnology can help tackling known problems in tissue engineering Covers materials design, fabrication techniques for tissue-specific applications as well as immunology and toxicology aspects Helps scientists and lab engineers building tissue substitutes in a more efficient way
As the impact and importance of nanotechnology continues to grow, nanomedicine and biotechnology have become areas of increased development. Drug delivery by nanoparticulates and nanocoatings for medicial devices are among the many new techniques on the horizon. Years from now we will laugh at the approaches to treating disease we currently conside
|Author||: Filippo Rossi,Alberto Rainer|
|Release Date||: 2020-08-22|
|ISBN 10||: 0128178396|
|Pages||: 322 pages|
Nanomaterials for Theranostics and Tissue Engineering: Techniques, Trends and Applications provides information on the major methodologies for the application of nanomaterials in the medical field. In recent years, nanotechnology for medicine, commonly known as bionanotechnology, or nanomedicine, has revolutionized various types of medical treatment. This book is intended for practicing engineers and scientists, and includes detailed, readily applicable protocols. It focuses on 4 major themes, including the synthesis of nanosystems for controlled drug delivery, nanotechnology-enhanced sensing systems, the application of nanotechnologies to the synthesis of novel biomaterials, and safety issues related to the application of medicinal nanotechnology. Provides a comprehensive overview on how nanotechnology is being used to create new tissue engineering techniques Covers, in detail, the physicochemical fundamentals of bionanotechnologies Explores major applications in the fields of theranostics and tissue engineering Assesses important challenges and safety issues related to the implementation of nanotechnology in medicine
Discussions of the basic structural, nanotechnology, and system engineering principles, as well as an introductory overview of essential concepts and methods in biotechnology, will be included. Text is presented side-by-side with extensive use of high-quality illustrations prepared using cutting edge computer graphics techniques. Includes numerous examples, such applications in genetic engineering. Represents the only available introduction and overview of this interdisciplinary field, merging the physical and biological sciences. Concludes with the authors' expert assessment of the future promise of nanotechnology, from molecular "tinkertoys" to nanomedicine. David Goodsell is author of two trade books, Machinery of Life and Our Molecular Nature, and Arthur Olson is the world's leader in molecular graphics and nano-scale representation.
Nanotechnology is the key technology of the 21st century. The possibility to exploit the structures and processes of biomolecules for novel functional materials, biosensors, bioelectronics and medical applications has created the rapidly growing field of nanobiotechnology. Designed as a broad survey of the field, this book combines contributions from bioorganic and bioinorganic chemistry, molecular biology, materials science and bioanalytics to fathom the full scope of current and future developments. It is divided into four main sections: * Interphase Systems * Protein-based Nanostructures * DNA-based Nanostructures * Nanoanalytics Each chapter describes in detail currently available methods and contains numerous references to the primary literature, making this the perfect "field guide" for chemists, biologists and materials scientists who want to explore the fascinating world of nanobiotechnology.
Fundamental Biomaterials: Metals provides current information on the development of metals and their conversion from base materials to medical devices. Chapters analyze the properties of metals and discuss a range of biomedical applications, with a focus on orthopedics. While the book will be of great use to researchers and professionals in the development stages of design for more appropriate target materials, it will also help medical researchers understand, and more effectively communicate, the requirements for a specific application. With the recent introduction of a number of interdisciplinary bio-related undergraduate and graduate programs, this book will be an appropriate reference volume for students. It represents the second volume in a three volume set, each of which reviews the most important and commonly used classes of biomaterials, providing comprehensive information on materials properties, behavior, biocompatibility and applications. Provides current information on metals and their conversion from base materials to medical devices Includes analyses of types of metals, discussion of a range of biomedical applications, and essential information on corrosion, degradation and wear and lifetime prediction of metal biomaterials Explores both theoretical and practical aspects of metals in biomaterials
Written by authors from different fields to reflect the interdisciplinary nature of the topic, this book guides the reader through new nano-materials processing inspired by nature. Structured around general principles, each selection and explanation is motivated by particular biological case studies. This provides the background for elucidating the particular principle in a second section. In the third part, examples for applying the principle to materials processing are given, while in a fourth subsection each chapter is supplemented by a selection of relevant experimental and theoretical techniques.