biomarkers for traumatic brain injury

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Biomarkers for Traumatic Brain Injury
Author : Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publisher : Royal Society of Chemistry
Release Date : 2012
ISBN 10 : 1849733899
Pages : 226 pages

Examines current and prospective biomarkers for assessment of traumatic brain injury using a multidisciplinary approach involving biochemistry, molecular biology and clinical chemistry.

Biomarkers for Traumatic Brain Injury
Author : Alan H.B. Wu,W. Frank Peacock
Publisher : Academic Press
Release Date : 2020-07-10
ISBN 10 : 0128167300
Pages : 486 pages

Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers. Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities. Offers strategies for the selection and implementation of traumatic brain injury biomarkers Discusses the importance of autoantibodies and post translational modifications for TBI Covers the analytical tools needed to implement TBI biomarkers, including the specifications for testing instruments and interpretative software

Translational Research in Traumatic Brain Injury
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Release Date : 2015-12-01
ISBN 10 : 1498766579
Pages : 412 pages

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Biomarkers of Brain Injury and Neurological Disorders
Author : Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publisher : CRC Press
Release Date : 2014-10-28
ISBN 10 : 1482239825
Pages : 650 pages

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Brain Neurotrauma
Author : Firas H. Kobeissy
Publisher : CRC Press
Release Date : 2015-02-25
ISBN 10 : 1466565993
Pages : 725 pages

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Annual Update in Intensive Care and Emergency Medicine 2017
Author : Jean-Louis Vincent
Publisher : Springer
Release Date : 2017-03-31
ISBN 10 : 3319519085
Pages : 545 pages

The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive reference book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Author : Kevin Wang
Publisher : Oxford University Press, USA
Release Date : 2018-12-05
ISBN 10 : 0190279435
Pages : 528 pages

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

From Bench to BedsideTrauma, Tumors, Spine, Functional Neurosurgery
Author : Francesco Signorelli
Publisher : BoD – Books on Demand
Release Date : 2016-09-28
ISBN 10 : 9535126288
Pages : 168 pages

This book is written for graduate students, researchers, and practitioners who are interested in learning how the knowledge from research can be implemented in clinical competences. The first section is dedicated to deep brain stimulation, a surgical procedure which is the paramount example of how clinical practice can take advantage from fundamental research. The second section gathers four chapters on four different topics and illustrates how significant is the challenge to translate scientific advances into clinical practice because the route from evidence to action is not always obvious. It is hoped that this book will stimulate the interest in the process of translating research into practice for a broader range of neurosurgical topics than the one covered by this book, which could result in a forthcoming more comprehensive publication.

Imaging Biomarkers in the Hyper-acute Phase Following Traumatic Brain Injury
Author : Tim Lawrence
Publisher : N.A
Release Date : 2018
ISBN 10 :
Pages : 329 pages

Sports-Related Concussion
Author : Julian E. Bailes,Mark R. Lovell,Joseph Maroon, MD
Publisher : CRC Press
Release Date : 1999
ISBN 10 :
Pages : 261 pages

The phenomenon of minor head injury is increasingly being recognized as having both immediate and long-term implications for athletes. Physicians, trainers, and coaches play a vital role in the prevention of injury, on-field diagnosis and management, and treatment of sports related concussion. From early recognition of a concussive event to treatment options and possible long-term side effects, all aspects of the neurologic and neuropsychologic evaluation and management of head injury in the athlete are addressed. The book concludes with a lively and informative round-table discussion among professional athletes who have experienced sports-related concussion.

Traumatic Brain Injury
Author : Jordan Grafman,Andres M. Salazar
Publisher : Elsevier
Release Date : 2015-02-19
ISBN 10 : 0444634983
Pages : 490 pages

The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI. Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injury Explores cellular and molecular mechanisms as well as genetic predictors of outcome Offers coverage of various diagnostic tools – CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and more State-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care

Concussion and Traumatic Encephalopathy
Author : Jeff Victoroff,Erin D. Bigler
Publisher : Cambridge University Press
Release Date : 2019-02-28
ISBN 10 : 1107073952
Pages : 890 pages

Readers will discover how very recent scientific advances have overthrown a century of dogma about concussive brain injury.

Management of Severe Traumatic Brain Injury
Author : Terje Sundstrøm,Per-Olof Grände,Niels Juul,Carsten Kock-Jensen,Bertil Romner,Knut Wester
Publisher : Springer Science & Business Media
Release Date : 2012-06-25
ISBN 10 : 3642281265
Pages : 417 pages

In order to reduce the number of deaths from severe head injuries, systematic management is essential. This book is a practical, comprehensive guide to the treatment of patients (both adults and children) with such injuries, from the time of initial contact through to the rehabilitation center. Sections are devoted to prehospital treatment, admission and diagnostics, acute management, and neurointensive care and rehabilitation. Evidence-based recommendations are presented for each diagnostic and therapeutic measure, and tips, tricks, and pitfalls are highlighted. Throughout, the emphasis is on the provision of sound clinical advice that will maximize the likelihood of an optimal outcome. Helpful flowcharts designed for use in daily routine are also provided. The authors are all members of the Scandinavian Neurotrauma Committee and have extensive practical experience in the areas they write about.

Pediatric Traumatic Brain Injury
Author : Vicki Anderson,Keith Owen Yeates
Publisher : Cambridge University Press
Release Date : 2010-02-04
ISBN 10 : 0521763320
Pages : 235 pages

"This book, New Frontiers in Pediatric Traumatic Brain Injury, aims to evaluate what we have learned about TBI in childhood to date and, perhaps more importantly to articulate the challenges we face and how we should go forward in the future"--Provided by publisher.

Biomarkers in Neurology
Author : Mohamed Mosaad Salama,Stefania Mondello,Firas H. Kobeissy,Wael M. Y. Mohamed
Publisher : Frontiers Media SA
Release Date : 2020-05-12
ISBN 10 : 2889636933
Pages : 329 pages

Imaging Biomarkers in Epilepsy
Author : Andrea Bernasconi,Neda Bernasconi,Matthias Koepp
Publisher : Cambridge University Press
Release Date : 2019-01-10
ISBN 10 : 1107108357
Pages : 272 pages

Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.

Traumatic Brain Injury
Author : Robert P. Granacher, Jr.
Publisher : CRC Press
Release Date : 2003-06-27
ISBN 10 : 9780203501740
Pages : 528 pages

Numerous books exist on traumatic brain injury, yet none comprehensively cover evaluation from both clinical and forensic standpoints. Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment is the first medical book to guide treatment practitioners not only in methods for evaluating traumatic brain injury in adults and children, but also in the important elements of forensic brain injury assessment. From the clinical aspect, the book details neurobehavioral data analysis and describes how to apply it to treatment planning and pharmacotherapy following traumatic brain injury. From the forensic perspective, it provides methods for detecting deception at examination and emphasizes the important legal concepts of causation, damages, and impairment determination following traumatic brain injury. The text provides multiple explanatory tables, structural and functional brain imaging figures, and liberal case examples of actual traumatic brain injury examinations and reports. The practical and pragmatic approach offered in Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment will aid clinicians and forensic specialists in comprehensively evaluating the TBI patient and successfully presenting the evaluation in the courtroom.

Textbook of Traumatic Brain Injury, Third Edition
Author : Jonathan M. Silver, M.D.,Thomas W. McAllister, M.D.,David B. Arciniegas, M.D.
Publisher : American Psychiatric Pub
Release Date : 2018-12-05
ISBN 10 : 1615371125
Pages : 985 pages

Despite the increased public awareness of traumatic brain injury (TBI), the complexities of the neuropsychiatric, neuropsychological, neurological, and other physical consequences of TBI of all severities across the lifespan remain incompletely understood by patients, their families, healthcare providers, and the media. Keeping pace with advances in the diagnosis, treatment, and science of TBI, the Textbook of Traumatic Brain Injury, Third Edition, comprehensively fills this gap in knowledge. Nearly all 50 chapters feature new authors, all of them experts in their field. Chapters new to this edition include biomechanical forces, biomarkers, neurodegenerative dementias, suicide, endocrine disorders, chronic disease management, and social cognition. An entirely new section is devoted to the evaluation and treatment of mild TBI, including injuries in athletes, military service members and veterans, and children and adolescents. These chapters join newly updated sections on the assessment and treatment of the cognitive, emotional, behavioral, and other physical sequelae of TBI. The Textbook of Traumatic Brain Injury is a must-read for all of those working in any of the multitude of disciplines that contribute to the care and rehabilitation of persons with brain injury. This new volume is also a potentially useful reference for policymakers in both the public and private sectors.

Brain Injury Medicine E-Book
Author : Blessen C. Eapen,David X. Cifu
Publisher : Elsevier Health Sciences
Release Date : 2020-07-17
ISBN 10 : 0323779441
Pages : 352 pages

The only review book currently available in this complex field, Brain Injury Medicine: Board Review focuses on the prevention, diagnosis, treatment, and management of individuals with varying severity levels of brain injury. Focused, high-yield content prepares you for success on exams and in practice, with up-to-date coverage of traumatic brain injury (TBI), stroke, CNS neoplasms, anoxic brain injury, and other brain disorders. This unique review tool is ideal for residents, fellows, and practitioners studying or working in the field and preparing to take the brain injury medicine exam. Supports self-assessment and review with 200 board-style questions and explanations. Covers the information you need to know on traumatic brain injury by severity and pattern, neurologic disorders, systemic manifestations, rehabilitation problems and outcomes, and basic science. Includes questions on patient management including patient evaluation and diagnosis, prognosis/risk factors, and applied science. Discusses key topics such as neurodegeneration and dementia; proteomic, genetic, and epigenetic biomarkers in TBI; neuromodulation and neuroprosthetics; and assistive technology. Reviews must-know procedures including acute emergency management and critical care; post-concussion syndrome assessment, management and treatment; diagnostic procedures and electrophysiology; neuroimaging, and brain death criteria. Ensures efficient, effective review with content written by experts in physical medicine and rehabilitation, neurology, and psychiatry and a format that mirrors the board exam outline.

Traumatic Brain Injury
Author : Nikolai Gorbunov,Joseph Long
Publisher : BoD – Books on Demand
Release Date : 2018-05-09
ISBN 10 : 1789231167
Pages : 242 pages

Traumatic brain injury (TBI) syndrome has emerged as a serious health concern worldwide due to the severity of outcomes and growing socioeconomic impacts of the diseases, e.g., high cost of long-term medical care and loss of quality of life. This book focuses on the TBI pathobiology as well as on the recent developments in advanced diagnostics and acute management. The presented topics encompass personal experience and visions of the chapter contributors as well as an extensive analysis of the TBI literature. The book is addressed to a broad audience of readers from students to practicing clinicians.