Axial Spondyloarthritis is a timely addition to the Oxford Textbooks in Rheumatology series, providing a comprehensive reference to this rapidly evolving field. The conceptual framework of the disease has now evolved beyond ankylosing spondylitis to encompass a broader concept of axial inflammation. Earlier recognition has opened the door to earlier intervention, and the understanding of the biologic basis of axial SpA has seen significant advances in recent years. The first textbook to cover axial spondyloarthritis in this level of detail from a global perspective, this volume offers a practical and complete resource compiled by a multidisciplinary and multinational team of experts. Beginning with a historical perspective on the disease, the textbook provides a comprehensive background in the epidemiology, diagnosis, and classification of axial spondyloarthritis. Immune mechanisms and genetics are covered, along with imaging and a detailed section on the range of treatments options currently available. A section on extra-articular manifestations provides a comprehensive knowledge base for the clinician treating patients with spondyloarthritis, and chapters on the economics of the disease, physical functioning, and patient registries complete the broad coverage of the topic. Practical, easy to use, yet detailed with respect to pathophysiology, diagnostics, and management, this textbook provides a comprehensive reference for rheumatologists, general practitioners, internists, and paediatricians managing patients with axial spondyloarthritis.
Axial spondyloarthritis is the commonest inflammatory arthritis affecting the spine. Typically first presenting to a variety of primary and secondary care professionals, the high global disease burden of this condition has created a need for increased awareness of this condition across a rangeof rheumatology specialties.A pocketbook aimed at the non-specialist reader Axial Spondyloarthritis is the essential guide to this common condition. Focusing on the practical implications of developments in classification, diagnosis and treatment, this easily accessible text fully covers the broader spectrum of the disease.Concise and fully illustrated, this addition to the Oxford Rheumatology Library covers the history and pathophysiology of axial spondylitis, alongside detailed sections on treatments, complications and manifestations of the condition. With each section supported by a handy key points section, AxialSpondyloarthritis is a useful and constructive resource for any practitioner or trainee encountering this condition.
Focusing on the key essentials you need to know, Axial Spondyloarthritis provides a quick, expert overview of axSpA from a clinical perspective. This concise resource by Drs. Philip Mease and Muhammad Khan presents practical recommendations and guidelines for the diagnosis, management, and treatment of spondyloarthritis impacting the axial skeleton alongside an overview of epidemiology, special populations, and patient education. Discusses key information on genetic factors and disease biomarkers. Presents an overview of clinical features, classification criteria, and imaging to aid in diagnosis. Covers management and treatment guidelines, including non-pharmacologic management and the use of biologics. Consolidates essential information on this timely topic into a single, convenient resource.
A thorough guide for readers to quickly gain an update on standard diagnosis and treatment methods for axial spondyloarthritis. Approximately 80 illustrations and images are used throughout the text to exemplify the disease and diagnostic and treatment algorithms. Easily accessible text and tables review the current treatment recommendations and emerging treatment options based on recent clinical trials.
|Author||: Sics Editore|
|Publisher||: SICS Editore|
|Release Date||: 2014-10-01|
|ISBN 10||: 8869304434|
|Pages||: 329 pages|
An integral feature of the disease is inflammation involving ligament insertion sites and facet joints of the spine as well as the sacroiliac (SI) joints. The condition often affects HLA-B27 positive individuals and belongs to the group of seronegative spondyloarthropathies together with reactive enteroarthritis and uroarthritis, Reiter’s syndrome enthesitis-related arthritis (ERA), a subgroup of juvenile idiopathic arthritis psoriatic arthritis arthropathy associated with inflammatory bowel disease. Several of the above conditions may be encountered in members of the same family, and they may all lead to ankylosing spondylitis. The condition is termed idiopathic when it has become chronic and no causative agent has been detected, unlike in reactive arthritis.
|Release Date||: 2017|
|Pages||: 329 pages|
Abstract The association between HLA-B27 and AS was first established in the early 1970s. Since then, our understanding of this disease has changed, such that we now recognize AS to be the extreme of the clinical phenotype within a disease spectrum known as axial SpA (axSpA). Recent advances in therapeutic options have driven the need for earlier diagnosis and many screening strategies have been proposed to facilitate this. In parallel, our understanding of axSpA genetics, and especially the contribution of HLA-B27, has expanded. In this article we will present and discuss the evidence supporting the use of HLA-B27 in clinical practice. We will briefly summarize the evolution of the concept of axSpA, the prevalence of HLA-B27 and axSpA and the potential role of HLA-B27 in the aetiopathogenesis of axSpA and focus on the utility of HLA-B27 in everyday clinical practice.
A practical comprehensive visual guide to the complex imaging appearance of axial spondyloarthritis in clinical practice. This atlas is a collaboration between diagnostic imaging and rheumatology, providing an extensive array of images that illustrate the diverse pathology that occurs in the SIJ and spine in patients with axial SpA. While the primary focus is on MRI there are also examples of plain radiographic and CT findings to highlight the comparative advantages and disadvantages of different imaging modalities. Additional images also illustrate the potential pitfalls of MRI and the wide imaging and clinical differential diagnosis that can be confused with axSpA. - User friendly with clear and concise descriptions of pathology with over 220 images. - Over 100 images of normal imaging anatomy. - Excellent visual guide for the radiologist and rheumatologist - State of the art imaging. - All cases are derived from rheumatology referral and offer excellent insight into everyday practice. - Supported by reference drawing, summary tables. - Includes a clinical case challenge with multiple MRI cases for review. - Provides an in-depth review of a new MRI reporting system for axial SpA in clinical practice
|Author||: Xenofon Baraliakos,Michael H. Weisman|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2020-06-02|
|ISBN 10||: 0323733786|
|Pages||: 240 pages|
This issue of Rheumatic Disease Clinics, guest edited by Drs. Xenofon Baraliakos and Michael H. Weisman, Spondyloarthritis: The Changing Landscape Today, takes a very comprehensive look at all of the essential topics surrounding spondyloarthritis. This issue is one of four selected each year by Dr. Weisman, who is also our series consulting editor. This very comprehensive issue will include the following topics (among others): Molecular biology approaches to understanding SpA; Microbiome and its role in SpA; Classification criteria in axSpA; Administrative data and coding for axSpA; Approach to the patient with IBD and AxSpA; Axial PsA vs. Axial SpA with Psoriasis; Emerging imaging techniques in SpA; The future of imaging in axSpA; Treatment Recommendations vs. Treat to Target in axSpA; The future of axSpA treatmentAxSpA in the era of Precision Medicine; Quality of Life as an outcome in studies of axSpA; Gender differences in SpA; The patient’s perspective on the burden of disease in axSpA; and Juvenile SpA.
|Author||: Juergen Braun,Joachim Sieper|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2012-11-14|
|ISBN 10||: 1455750603|
|Pages||: 240 pages|
Edited by Drs. Juergen Braun and Joachim Sieper, this issue of Rheumatic Disease Clinics comprehensively reviews the state of the art of spondyloarthritis (SpA) diagnosis, prognosis, pathogenesis and genetic insights, and treatment. The worldwide burden of SpA now exceeds that of rheumatoid arthritis. General topics covered include inflammatory back pain, pathophysiology, imaging techniques, and therapeutic strategies.
Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics. Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation. Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field. Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.
|Release Date||: 2012-01-09|
|ISBN 10||: 1464963134|
|Pages||: 15 pages|
Spondylarthritis: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Spondylarthritis in a compact format. The editors have built Spondylarthritis: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Spondylarthritis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Spondylarthritis: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
|Release Date||: 2013-07-22|
|ISBN 10||: 1481650610|
|Pages||: 32 pages|
Ankylosing Spondylitis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Additional Research in a compact format. The editors have built Ankylosing Spondylitis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ankylosing Spondylitis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
|Author||: Ivor Benjamin,Robert C. Griggs,Thomas E. Andreoli,J. Gregory Fitz|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2010-04-06|
|ISBN 10||: 1437726739|
|Pages||: 1312 pages|
Students, residents, and instructors swear by Andreoli and Carpenter’s Cecil Essentials of Medicine because it presents just the right amount of information, just the right way. Edited by the late Thomas E. Andreoli, MD as well as Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it focuses on core principles and how they apply to patient care, covering everything you need to know to succeed on a medical rotation or residency. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible. New chapters on "Pre- and Post-Operative Care" and "Palliative Care," plus the integration of molecular biology and other new horizons in medicine, familiarize you with the most current clinical concepts. An expanded International Editorial Board provides increased input from respected practitioners worldwide. Excellent images and clinical photographs vividly illustrate the appearance and clinical features of disease. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible.
An overview of diagnosis and current management of ankylosing spondylitis. Presented in a clear, concise format High quality clinical photos and figures to enhance descriptions and aid diagnosis Written by well-known authors in the field
|Author||: Karen Torralba,Francisco P. Quismorio,Richard S. Panush|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2012-08-08|
|ISBN 10||: 1455744360|
|Pages||: 216 pages|
To ensure the best possible clinical outcomes for arthritis patients, it is essential that they be seen early and treated appropriately at the earliest opportunity. Early therapy has proven much more effective than that given late. This issue of Rheumatic Disease Clinics of North America brings the rheumatologist up to date on the latest treatments and interventions in evolving arthritis and established early arthritis. Topics covered include early rheumatoid arthritis, psoriatic arthritis, undifferentiated arthritis, oligoarthritis, osteoarthritis, and others. Imaging modalities are addressed as well as various contemporary treatments including biologics.
Ankylosing Spondylitis in Clinical Practice is a concise, practical guide on the diagnosis and management of this debilitating condition. This book is aimed at clinicians who treat Ankylosing Spondylitis. It provides an authoritative, accessible guide to the diagnosis, management and treatment of ankylosing spondylitis.
Abstract : Purpose of review: To assess the literature for biomarker validation studies that address key unmet needs related to the evaluation and management of patients with axial spondyloarthritis (SpA). This review focused on biomarkers facilitating early diagnosis and reflecting disease activity, structural damage on radiography, and clinical response to major therapies. Recent findings: Early diagnosis may be facilitated by measurement of antibodies to the human leukocyte antigen class II-associated invariant chain peptide (anti-CD74) but sensitivity declines with increasing duration of disease. No disease activity biomarkers have demonstrated consistent superiority over standard C-reactive protein (CRP), and future validation should employ multivariate analysis aimed at demonstrating the added value of any associated biomarkers beyond available clinical parameters of disease activity and the use of magnetic resonance imaging inflammation as the primary endpoint. Several biomarkers reflecting inflammation (CRP and calprotectin), angiogenesis (vasoactive endothelial growth factor), and connective tissue turnover (C2 M, C3 M, and citrullinated metalloproteinase degraded fragment of vimentin ) have recently been shown to reflect radiographic progression in multivariate studies adjusted for baseline severity. Future studies should be prospective and demonstrate that predictive capacity adds to the information provided by known predictors such as CRP and baseline modified Stoke AS Spine Score. Calprotectin is a promising predictor of response to major therapies for axial SpA. Summary: Several promising biomarkers addressing major unmet clinical needs require further validation in prospective studies.
This richly illustrated and comprehensive case-based atlas documents the MR findings observed in spondyloarthritis and offers guidance on selection of the appropriate imaging protocol, which is critical in detecting the potentially very subtle changes. The presented MR study protocols include T2-weighted sequences with fat saturation and contrast-enhanced T1-weighted sequences with fat saturation, these being sequences which permit better visualization of inflammatory changes of both anterior and posterior elements of the spine. Cases of spondylitis, discitis, osteoarthritis and sacroiliitis are described and concise information is provided on the clinical history of the rheumatic diseases. The inclusion of a large number of high-resolution images ensures that the atlas will serve as a guide to differentiation between potentially confounding diseases and an aid to early diagnosis, which has become essential with the advent of new treatments in the field of spondyloarthritis (TNF inhibitors). In addition to radiologists, neuroradiologists, rheumatologists, orthopedists and physiatrists will greatly benefit from the contents of this volume and its thorough presentation of the rheumatic diseases.