Axial Spondyloarthritis is a timely addition to the Oxford Textbooks in Rheumatology series, providing a comprehensive reference to this rapidly evolving field. The conceptual framework of the disease has now evolved beyond ankylosing spondylitis to encompass a broader concept of axial inflammation. Earlier recognition has opened the door to earlier intervention, and the understanding of the biologic basis of axial SpA has seen significant advances in recent years. The first textbook to cover axial spondyloarthritis in this level of detail from a global perspective, this volume offers a practical and complete resource compiled by a multidisciplinary and multinational team of experts. Beginning with a historical perspective on the disease, the textbook provides a comprehensive background in the epidemiology, diagnosis, and classification of axial spondyloarthritis. Immune mechanisms and genetics are covered, along with imaging and a detailed section on the range of treatments options currently available. A section on extra-articular manifestations provides a comprehensive knowledge base for the clinician treating patients with spondyloarthritis, and chapters on the economics of the disease, physical functioning, and patient registries complete the broad coverage of the topic. Practical, easy to use, yet detailed with respect to pathophysiology, diagnostics, and management, this textbook provides a comprehensive reference for rheumatologists, general practitioners, internists, and paediatricians managing patients with axial spondyloarthritis.
Focusing on the key essentials you need to know, Axial Spondyloarthritis provides a quick, expert overview of axSpA from a clinical perspective. This concise resource by Drs. Philip Mease and Muhammad Khan presents practical recommendations and guidelines for the diagnosis, management, and treatment of spondyloarthritis impacting the axial skeleton alongside an overview of epidemiology, special populations, and patient education. Discusses key information on genetic factors and disease biomarkers. Presents an overview of clinical features, classification criteria, and imaging to aid in diagnosis. Covers management and treatment guidelines, including non-pharmacologic management and the use of biologics. Consolidates essential information on this timely topic into a single, convenient resource.
Axial spondyloarthritis is the commonest inflammatory arthritis affecting the spine. Typically first presenting to a variety of primary and secondary care professionals, the high global disease burden of this condition has created a need for increased awareness of this condition across a rangeof rheumatology specialties.A pocketbook aimed at the non-specialist reader Axial Spondyloarthritis is the essential guide to this common condition. Focusing on the practical implications of developments in classification, diagnosis and treatment, this easily accessible text fully covers the broader spectrum of the disease.Concise and fully illustrated, this addition to the Oxford Rheumatology Library covers the history and pathophysiology of axial spondylitis, alongside detailed sections on treatments, complications and manifestations of the condition. With each section supported by a handy key points section, AxialSpondyloarthritis is a useful and constructive resource for any practitioner or trainee encountering this condition.
|Author||: Xenofon Baraliakos,Michael H. Weisman|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2020-06-02|
|ISBN 10||: 0323733786|
|Pages||: 240 pages|
This issue of Rheumatic Disease Clinics, guest edited by Drs. Xenofon Baraliakos and Michael H. Weisman, Spondyloarthritis: The Changing Landscape Today, takes a very comprehensive look at all of the essential topics surrounding spondyloarthritis. This issue is one of four selected each year by Dr. Weisman, who is also our series consulting editor. This very comprehensive issue will include the following topics (among others): Molecular biology approaches to understanding SpA; Microbiome and its role in SpA; Classification criteria in axSpA; Administrative data and coding for axSpA; Approach to the patient with IBD and AxSpA; Axial PsA vs. Axial SpA with Psoriasis; Emerging imaging techniques in SpA; The future of imaging in axSpA; Treatment Recommendations vs. Treat to Target in axSpA; The future of axSpA treatmentAxSpA in the era of Precision Medicine; Quality of Life as an outcome in studies of axSpA; Gender differences in SpA; The patient’s perspective on the burden of disease in axSpA; and Juvenile SpA.
A thorough guide for readers to quickly gain an update on standard diagnosis and treatment methods for axial spondyloarthritis. Approximately 80 illustrations and images are used throughout the text to exemplify the disease and diagnostic and treatment algorithms. Easily accessible text and tables review the current treatment recommendations and emerging treatment options based on recent clinical trials.
A practical comprehensive visual guide to the complex imaging appearance of axial spondyloarthritis in clinical practice. This atlas is a collaboration between diagnostic imaging and rheumatology, providing an extensive array of images that illustrate the diverse pathology that occurs in the SIJ and spine in patients with axial SpA. While the primary focus is on MRI there are also examples of plain radiographic and CT findings to highlight the comparative advantages and disadvantages of different imaging modalities. Additional images also illustrate the potential pitfalls of MRI and the wide imaging and clinical differential diagnosis that can be confused with axSpA. - User friendly with clear and concise descriptions of pathology with over 220 images. - Over 100 images of normal imaging anatomy. - Excellent visual guide for the radiologist and rheumatologist - State of the art imaging. - All cases are derived from rheumatology referral and offer excellent insight into everyday practice. - Supported by reference drawing, summary tables. - Includes a clinical case challenge with multiple MRI cases for review. - Provides an in-depth review of a new MRI reporting system for axial SpA in clinical practice
Abstract : Purpose of review: To assess the literature for biomarker validation studies that address key unmet needs related to the evaluation and management of patients with axial spondyloarthritis (SpA). This review focused on biomarkers facilitating early diagnosis and reflecting disease activity, structural damage on radiography, and clinical response to major therapies. Recent findings: Early diagnosis may be facilitated by measurement of antibodies to the human leukocyte antigen class II-associated invariant chain peptide (anti-CD74) but sensitivity declines with increasing duration of disease. No disease activity biomarkers have demonstrated consistent superiority over standard C-reactive protein (CRP), and future validation should employ multivariate analysis aimed at demonstrating the added value of any associated biomarkers beyond available clinical parameters of disease activity and the use of magnetic resonance imaging inflammation as the primary endpoint. Several biomarkers reflecting inflammation (CRP and calprotectin), angiogenesis (vasoactive endothelial growth factor), and connective tissue turnover (C2 M, C3 M, and citrullinated metalloproteinase degraded fragment of vimentin ) have recently been shown to reflect radiographic progression in multivariate studies adjusted for baseline severity. Future studies should be prospective and demonstrate that predictive capacity adds to the information provided by known predictors such as CRP and baseline modified Stoke AS Spine Score. Calprotectin is a promising predictor of response to major therapies for axial SpA. Summary: Several promising biomarkers addressing major unmet clinical needs require further validation in prospective studies.
|Release Date||: 2017|
|Pages||: 329 pages|
Abstract The association between HLA-B27 and AS was first established in the early 1970s. Since then, our understanding of this disease has changed, such that we now recognize AS to be the extreme of the clinical phenotype within a disease spectrum known as axial SpA (axSpA). Recent advances in therapeutic options have driven the need for earlier diagnosis and many screening strategies have been proposed to facilitate this. In parallel, our understanding of axSpA genetics, and especially the contribution of HLA-B27, has expanded. In this article we will present and discuss the evidence supporting the use of HLA-B27 in clinical practice. We will briefly summarize the evolution of the concept of axSpA, the prevalence of HLA-B27 and axSpA and the potential role of HLA-B27 in the aetiopathogenesis of axSpA and focus on the utility of HLA-B27 in everyday clinical practice.
|Author||: Juergen Braun,Joachim Sieper|
|Release Date||: 2012-10-29|
|ISBN 10||: 9781455750665|
|Pages||: 240 pages|
Edited by Drs. Juergen Braun and Joachim Sieper, this issue of Rheumatic Disease Clinics comprehensively reviews the state of the art of spondyloarthritis (SpA) diagnosis, prognosis, pathogenesis and genetic insights, and treatment. The worldwide burden of SpA now exceeds that of rheumatoid arthritis. General topics covered include inflammatory back pain, pathophysiology, imaging techniques, and therapeutic strategies.