|Author||: Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson|
|Publisher||: Academic Press|
|Release Date||: 2015-08-21|
|ISBN 10||: 0128018631|
|Pages||: 538 pages|
Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals
This book offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease. The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine. The book has consistent chapter organization relevant to modern cardiovascular practice, clear design and engaging text. The reader will have all the guidance to diagnose and manage the full range of cardiovascular conditions in one textbook resource, while also benefiting from access to additional video material from the integral DVD-ROM. This includes over 100 individual heart sounds.
|Author||: Dennis V. Cokkinos|
|Release Date||: 2014-11-06|
|ISBN 10||: 3319087983|
|Pages||: 610 pages|
The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.
|Author||: Thomas F. Kresina|
|Publisher||: John Wiley & Sons|
|Release Date||: 2004-04-07|
|ISBN 10||: 0471461040|
|Pages||: 416 pages|
Gene therapy, or the use of genetic manipulation for diseasetreatment, is derived from advances in genetics, molecular biology,clinical medicine, and human genomics. Molecular medicine, theapplication of molecular biological techniques to disease treatmentand diagnosis, is derived from the development of human organtransplantation, pharmacotherapy, and elucidation of the humangenome. An Introduction to Molecular Medicine and GeneTherapy provides a basis for interpreting new clinical andbasic research findings in the areas of cloning, gene transfer, andtargeting; the applications of genetic medicine to clinicalconditions; ethics and governmental regulations; and the burgeoningfields of genomics, biotechnology, and bioinformatics. By dividingthe material into three sections - an introduction to basicscience, a review of clinical applications, and a discussion of theevolving issues related to gene therapy and molecular medicine-thiscomprehensive manual describes the basic approaches to the broadrange of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine andGene Therapy: Covers new frontiers in gene therapy, animal models, vectors,gene targeting, and ethical/legal considerations Provides organ-based reviews of current studies in gene therapyfor monogenetic, multifactoral or polygenic disorders, andinfectious diseases Includes bold-faced terms, key concepts, summaries, and listsof helpful references by subject in each chapter Contains appendices on commercial implications and a review ofthe history of gene therapy This textbook offers a clear, concise writing style, drawingupon the expertise of the authors, all renowned researchers intheir respective specialties of molecular medicine. Researchers ingenetics and molecular medicine will all find An Introductionto Molecular Medicine and Gene Therapy to be an essentialguide to the rapidly evolving field of gene therapy and itsapplications in molecular medicine.
|Author||: S. C. Mockrin|
|Publisher||: CRC Press|
|Release Date||: 1996-01-02|
|ISBN 10||: 9780824794088|
|Pages||: 616 pages|
Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases--including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nearly 50 investigators on the cutting-edge of pioneering research in the field.
This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage potentially induced by antineoplastic drugs. Thanks to more and more effective antineoplastic treatments the survival of cancer patients is enormously increasing, but at the same time it is increasing the burden of related cardiovascular complications that affect morbidity and mortality. On this basis a new branch of cardiology has been developed, that is Cardio-Oncology. The aim is to prevent cardiovascular complications related to cancer therapy and to facilitate and avoid interruption of antineoplastic drugs due to the occurrence of cardiovascular damage. An increasing attention has been given to cardiac damage, while, until today, vascular complications have been poorly evaluated. The aim of this book is to focus on vascular complications related to cancer treatment, to guide the clinician at facing, during his every day practice, cardiovascular toxicity in cancer and hematologic patients. The proposed sections of the book have been structured to review the molecular mechanisms underlying vascular damage induced by new and old treatments, to describe the various manifestations of vascular disease that may range from artery to venous disease (including coronary artery disease, peripheral arterial disease, venous thromboembolism and pulmonary hypertension), and to provide advice to monitor patients undergoing onco-hematologic treatments in order to prevent and eventually manage vascular damage.This book will address resident and fellow physicians, medical oncologists, cardiologists, general practitioners and all those who take care of these patients.All invited authors will be recognized experts in their field, and leading international researchers on these topics. The editor has worked with these expert colleagues on a variety of other projects. The authors will provide their manuscript according to current literature and clinical research studies. The book does not seek to duplicate or replace other current resources. Rather, it will create a comprehensive yet concise resource on this emerging topic that is not adequately covered by any current literature.
|Author||: Kewal K. Jain|
|Publisher||: Springer Science & Business Media|
|Release Date||: 2011-07-25|
|ISBN 10||: 9781617792403|
|Pages||: 350 pages|
For physicians, surgeons, and scientists working on cardiovascular disorders, Applications of Biotechnology in Cardiovascular Therapeutics serves as an invaluable reference by collecting the essential writings of Dr. Kewal K. Jain on the topics of biotechnology as they relate to cardiovascular disease. This thorough volume includes such subjects as biotechnology and therapeutic delivery to the cardiovascular system, cell-selective targeted drug delivery, cell and gene therapies, including antisense and RNA interference, cutting-edge gene therapy approaches, as well as personalized cardiology as a way of integrating new technologies into the selection of the best possible treatment for an individual patient. Selected references from recent literature are collected for each chapter, and the text is supplemented by a variety of useful tables and figures. Comprehensive and up-to-date, Applications of Biotechnology in Cardiovascular Therapeutics will be tremendously useful for those working in life sciences and the pharmaceutical sciences, and the inclusion of some basics of cardiovascular diseases will greatly benefit nonmedical readers as well.
In recent years considerable progress and new developments in diagnostic and interventional cardiology have been observed, such as balloon angioplasty of coronary artery stenoses, reperfusion techniques in acute myocardial infarction, new pacing, and cardioversion-defibrillation techniques in ventricular tachyar rhythmias. On 5-8 May, 1985, an international symposium on 'Invasive Cardio vascular Therapy' was held in Cologne, which provided a survey on the experi ment~l and routine therapeutic measures presently available and practiced in cardiovascular medicine. This volume is based on the oral presentations given during the symposium. In five chapters the most important traditional and new interventional techniques are discussed by experts in the field. Chapter I contains a description of results from catheter palliation of congeni tal shunt disorders or relief of congenital pulmonary or aortic valve stenoses as well as the recent experience with surgical repair of single ventricle, Fallot's tetralogy and tricuspid atresia. Chapter II presents the surgical results of valve replacement with different valve prostheses in acquired valvular disease, the surgical management of bacte rial endocarditis, as well as the various techniques of partial transient left heart support devices and of cardiac transplantation. In chapter III, the invasive management of chronic coronary heart disease, peripheral vascular disease by balloon catheter or laser techniques, and the surgical approach to coronary heart disease are discussed.
|Author||: George Hunter|
|Release Date||: 1987|
|Pages||: 58 pages|
Cardiac Pacing: An Illustrated Introduction will provide an introduction to all those who have or who are developing an interest in cardiac pacing. At a time in the UK when pacing is being devolved from specialist tertiary cardiac centres to smaller district general hospitals and in the USA where pacemaker implantation is no longer the responsibility of the surgeon and in the domain of cardiologists, there is a need for a text which offers a guide to pacing issues to be used alongside a comprehensive practical training programme in an experienced pacing centre
|Author||: Luigi Padeletti|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2016-01-07|
|ISBN 10||: 0323402399|
|Pages||: 297 pages|
The latest developments in the field of Cardiac Resynchronization Therapy are featured in this issue of Cardiac Electrophysiology Clinics. The issue includes more than 20 articles in the following areas: heart failure; cost of heart failure; ventricular dissynchrony and resynchronization; assessment of dissynchrony; indication for CRT implantation; implantation technique; measures to improve CRT benefit on AF patients; and many more.
|Author||: Luigi Padeletti,Martina Nesti,Giuseppe Boriani|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2016-11-25|
|ISBN 10||: 0323482805|
|Pages||: 413 pages|
The latest developments in the field of Cardiac Resynchronization Therapy are featured in this issue of Heart Failure Clinics. Edited by Drs. Luigi Padeletti, Martina Nesti, and Giuseppe Boriani, the issue includes more than 20 articles in the following areas: heart failure; cost of heart failure; ventricular dissynchrony and resynchronization; assessment of dissynchrony; indication for CRT implantation; implantation technique; measures to improve CRT benefit on AF patients; and many more.
From medical disorders to toxicology to infectious disease, Kirk’s Current Veterinary Therapy XIV includes the most up-to-date information from leading experts in the veterinary field with over 260 new chapters. The user-friendly format presents content clearly to help you easily find the information you need and put it in practice. Selective lists of references and suggested readings provide opportunities for further research, and the Companion CD includes helpful information from the previous volume that still applies to current practice. Authoritative, reliable information on diagnosis includes details on the latest therapies. An organ-system organization makes it easy to find solutions for specific disorders. Concise chapters are only 2-5 pages in length, saving you time in finding essential information. Well-known writers and editors provide accurate, up-to-date coverage of important topics. A convenient Table of Common Drugs, updated by Dr. Mark Papich, offers a quick reference to dosage information. Cross-references to the previous edition make it easy to find related information that remains valid and current. A list of references and suggested readings is included at the end of most chapters. A fully searchable companion Evolve website adds chapters from Kirk’s Current Veterinary Therapy XIII, with information that has not changed significantly since its publication. It also includes an image collection with over 300 images, and references linked to PubMed. Useful appendices on the website provide a virtual library of valuable clinical references on laboratory test procedures and interpretation, normal reference ranges, body fluid analyses, conversion tables, nutritional profiles, a drug formulary, and more. More than 260 new chapters keep you at the leading edge of veterinary therapy.
Cardiac therapy has become ever more complex during the past quarter century. For example, 25 years ago, the therapy of cardiac failure was largely limited to digitalis, a very few diuretics, salt restriction, and general supportive measures. Antiarrhythmic therapy involved - in the main - quinidine, procainamide, and digitalis, and questions such as which arrhythmia to treat and how to measure drug efficacy had been addressed in elementary fashion only. Cardiac surgery was limited largely to congenital and valvular heart disease; the areas of cardiac pacemaker therapy, defibrillation and other forms of electrical diagnosis and therapy were rudimentary. The expansion of support of cardiovascular research by the National Institutes of Health as well as by institutional sources following World War II has led to major successes in clinical health care delivery and improved technology made available to clinical investigators. In reviewing progress over the past 25 years, we have been particularly impressed by one observation: this is the important interaction that has developed between studies of pathophysiology and the delivery of appropriate cardiac therapy.
Cardiac resynchronization therapy (CRT) is one of the most exciting new advances in the treatment of chronic severe (NYHA symptom class) heart failure associated with dyssynchronous ventricular contraction that is refractory to medical treatment. In all randomized trials CR has resulted in improved NYHA symptom class, exercise capacity and quality of life in the majority of patients as compared to patients on optimal medical therapy including angiotensin converting enzyme inhibitor (ACE)/angiotensin receptor blocker inhibitor (ARB) and b adrenergic receptor blockers. These symptomatic benefits are mediated by "reverse remodeling" of the left ventricle, that is reduction in volume, regression of LV mass, improvement in ejection fraction and severity of mitral regurgitation induced by synchronization of ventricular contraction. This new text is edited by 5 experts in heart failure, electrophysiology and non-invasive cardiac imaging and is extensively illustrated with high quality figures and examples of clinical cases. The purpose of the book is to put into perspective this novel therapy with regards to traditional heart failure treatment and to provide criteria for identifying patients likely to have an optimal and sustained response to CRT using a practical "how to" approach. This text begins by describing the background and evolution of the technique to the current implementation and the impact of complications on clinical outcome. There are chapters describing "cutting edge" Doppler echocardiography for assessing dyssynchrony, reverse remodeling and triaging patients into those with greatest likelihood of responding to CRT with illustrative clinical case examples. There is a full description of the results of all the randomized clinical trials and a number of chapters discussing the need for concomitant internal cardiac defibrillator (ICD), special circumstances such as atrial fibrillation, right bundle branch block, left ventricular lead placement and etiology of heart failure with clinical case examples for each.
Enthusiastically acclaimed by medical students and faculty worldwide, this text is specifically designed to prepare students for their first encounters with patients with cardiovascular disease. Thoroughly revised by internationally recognized Harvard Medical School faculty and a team of select cardiology fellows and internal medicine residents, this seventh edition equips students with a clear, complete, and clinically relevant understanding of cardiovascular pathophysiology, setting a strong foundation for patient diagnosis and management.
Cardiac Resynchronization Therapy continues to evolve at a rapidpace. Growing clinical experience and additional clinical trialsare resulting in changes in how patients are selected for CRT. This new edition of the successful Cardiac ResynchronizationTherapy builds on the strengths of the first edition, providingbasic knowledge as well as an up-to-date summary of new advances inCRT for heart failure. Fully updated to include information ontechnological advances, trouble shooting and recent key clinicaltrials, and with nine new chapters, this expanded text provides thelatest information, keeping the reader up-to-date with this rapidlyevolving field. The second edition of Cardiac Resynchronization Therapyis an essential addition to your collection.
|Author||: Joanne Watchie|
|Publisher||: Elsevier Health Sciences|
|Release Date||: 2009-09-08|
|ISBN 10||: 1437715702|
|Pages||: 448 pages|
Quick and convenient, this resource provides a clinical overview of a wide variety of diseases and disorders that affect the cardiovascular system and lungs and the physical therapy management of patients with them. It integrates key concepts of pathophysiology, clinical manifestations, diagnostic tests and laboratory information and findings with clinically important medical and surgical interventions and pharmacologic therapies — then applies the material to physical therapy evaluation and treatment. This edition adds an introductory chapter on the oxygen transport pathway, the effects of dysfunction along the pathway, and the implications for physical therapy. Offers a complete overview including basic cardiopulmonary anatomy and physiology, the pathophysiology of commonly encountered cardiac and pulmonary disorders, diagnostic tests and procedures, therapeutic interventions, pharmacology, physical therapy evaluation and treatment, and clinical laboratory values and profiles. Uses a bulleted format to make finding information quick and easy. Lists the latest drugs used for the treatment of cardiopulmonary disorders. Includes information on laboratory medicine and pediatrics to help you apply cardiopulmonary principles to practice. Follows the oxygen transport pathway — the delivery, uptake and, extrication of oxygen as it actually functions in a clinical setting — providing a logical framework for understanding cardiopulmonary concepts. Explains the implications of defects in the pathway — essential considerations for clinical practice. Includes a comprehensive listing of common cardiopulmonary diseases, as well as a number of other diseases that are associated with cardiopulmonary dysfunction. Provides new and updated illustrations that depict common pathologies such as the pathophysiology of left ventricular diastolic and systolic dysfunction, volume versus pressure overload, and dilated versus hypertrophies versus restrictive cardiomyophathies. Includes descriptions of important interventions such as lung volume reduction surgery and lung transplantation. Adds a new section on simple anthropometric measurements for determining obesity, with information on this demographic trend and how it impacts assessment.
|Author||: Raz Miri|
|Publisher||: KIT Scientific Publishing|
|Release Date||: 2009|
|ISBN 10||: 3866443609|
|Pages||: 293 pages|
Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies. The purpose of this book is to present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy. The book will start from the historic overview of the subject, including the development of the pacemaker and defibrillator, evolution of theories of cardiac arrhythmias and experimental methods used in the field over the centuries. Leading experts in the field will write these chapters. The second part of the book will focus on rigorous treatment of the fundamental theory of interaction between electric field and cardiac cell, tissue, and organ. Chapters will be written by top notch scientists, who made critically important contributions to the development of these theories. Part 3 will provide summary of several decades of research involving electrode recordings and multielectrode mapping of ventricular fibrillation and defibrillation in humans and animal models of arrhythmias. Part 4 will present new insights into defibrillation gained due to the advent of optical imaging technology, which permitted to map defibrillation without overwhelming shock-induced artifacts present in electrode recordings. Part 5 will provide rigorous overview of the methodologies, which made research of physiological and engineering aspects of electrotherapy possible. And finally, part 6 will present possible future of implantable devices and electrotherapy in the treatment of cardiac rhythm disorders.