Advances in Triazole Chemistry reviews the ever-widening scope of triazole chemistry. Triazole is an exceptional structural motif with a range of applications across scientific disciplines, including materials science, organocatalysis, agrochemicals, and medicinal chemistry. These many applications of different classes of triazoles have promoted the development of a range of synthetic strategies over the past few years, which are presented here along with recent and ecofriendly methods for the synthesis of all types of triazoles. The book also reviews the recent notable applications in chemical ligation, peptidomimetics, carbohydrate chemistry, nanotechnology, and polymer and materials science. This comprehensive resource is ideal for researchers using triazoles in various disciplines, as well as chemists working in the pharmaceutical, polymer, and agrochemical industries. Includes coverage of the role triazoles play in DNA synthesis Features comprehensive information on 1,2,3-triazoles and 1,2,4-triazoles and their subclasses, synthesis, and applications Serves as an ideal reference for researchers and chemists interested in using triazole chemistry for functionalization, modification, and development of target products
Advances in Heterocyclic Chemistry
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers
This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.
Advances in Inorganic Chemistry
Medicinal Chemistry Advances covers the proceedings of the Seventh International Symposium on Medicinal Chemistry. The book reviews the papers presented in the symposium. The main topics that this book covers are nucleosides in chemotherapy; theoretical approaches to medicinal chemistry; platelets and antithrombotic agents; receptors; antiviral agents; antilipidemic agents; respiratory system; central nervous system; enzyme inhibitors; and bioactive peptides. Chemists, pharmacologists, biochemists, physicians and other professionals and researchers concerned with the development of pharmaceuti ...
|Release Date||: 2013-05-01|
|ISBN 10||: 1490104755|
|Pages||: 294 pages|
Staphylococcus—Advances in Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Staphylococcus pseudintermedius. The editors have built Staphylococcus—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Staphylococcus pseudintermedius in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Staphylococcus—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
|Author||: Thomas F. DeRosa|
|Release Date||: 2006-03-21|
|ISBN 10||: 9780080455631|
|Pages||: 704 pages|
Advances in Synthetic Organic Chemistry and Methods Reported in US Patents provides synthetic guidelines for preparing current and commercially significant organic compounds, derivatives, and intermediates as reported in issued US Patents. Industries surveyed include agrochemical, cosmetics and personal care products. Each entry contains extensive information such as explicit laboratory directions for preparing all chemical intermediates and characterization data. Furthermore, product optimization studies, industrial preparation, and new synthetic methods have been included for selected entries, as well as projected research directions for future product development. In Advances in Synthetic Organic Chemistry and Methods Reported in US Patents the author's practical approach enables readers to identify research and market trends, and stay up-to-date on current developments in the field. Provides synthetic guidelines for preparing current and commercially significant organic compounds, derivatives, and intermediates as reported in issued US Patents Identifies product development trends to help determine research areas Elucidates use of the US Patent and Trademark Office database
To an increasing extent, "green chemistry" is a new chemical and engineering approach of chemistry and engineering, dedicated to make manufacturing processes and our world as a whole more sustainable world with a growing tendency. "Green chemistry" approaches are based on ecofriendly technologies, aiming to reduce or eliminate the use of solvents, or render them efficient and safer. Moreover, this scientific field is devoted to reduction or elimination of prevailing environmental and health threats, which typically accompany chemical products and traditional processes. The present book "Green Chemistry" contains 9 selected chapters, starting with a general introductory chapter on "green chemistry," and covers many recent applications and developments based on the principles of "green chemistry." This book is considered the appropriate way to communicate the advances in green materials and their applications to the scientific community. Chemists, scientists and researchers from related areas, and undergraduates involved in environmental issues and interested in approaches to improve the quality of life could find an inspiring and effective guide by reading this book.
ABPP Methodology: Introduction and Overview, by Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for Natural Product Target Discovery, by Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis, by William P. Heal und Edward W. Tate Functional Analysis of Protein Targets by Metabolomic Approaches, by Yun-Gon Kim und Alan Saghatelian
|Publisher||: Academic Press|
|Release Date||: 2014-12-02|
|ISBN 10||: 0128008059|
|Pages||: 506 pages|
Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
|Release Date||: 2012-01-09|
|ISBN 10||: 1464920788|
|Pages||: 1045 pages|
Electrolytes: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Electrolytes. The editors have built Electrolytes: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Electrolytes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Electrolytes: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
This book provides a wealth of fascinating chemistry not documented elsewhere. Readers will find much of interest in this illuminating volume.
Chapter 1 reviews recent progress in aryne cycloaddition reactions. The important contributions to the methodology of preparation of arynes in mild reaction conditions are described. Among them, the in-situ generation of arynes via the reaction of ortho- OTMS aryl triflates with fluoride ions is the most applicable. By this method, a variety of arynophiles was employed in the synthesis of nitrogen and oxygen containing 5-7 membered heterocycles. Instructive examples of applications in the total synthesis of natural products (radermachol, (±)-tylophorine, calothrixins, tubingensin B, (+)-hinckdentine A, cossonidine and (methyl)teretifoliones B) are presented. The importance of O-trimethylsilylaryl triflates and fluoride ions methodology for aryne generation is demonstrated in preparation of bioactive molecules and their applicability in medicinal chemistry research. Chapter 2. In addition to thermal reactions, photocycloaddition reactions are a complementary tool in synthetic organic chemistry. The employment of photochemical cycloaddition reactions proceed through different reaction mechanisms and provide access to products which could not be obtained in classical reaction conditions. This chapter is a review of excited state transformations of heterostilbenes to polycyclic structures featuring bicyclo[2.1.1], bicyclo[3.1.0] and bicyclo[3.2.1] moieties. Alongside the main products of these types, often unexpected transformations take place. Some of the photocycloaddition products display interesting biological activity. Chapter 3 reports the results of original scientific research with regards to the application of click reactions in the synthesis of 1,4-disubstituted 1,2,3-triazole conjugates with ribofuranosides and reversed nucleosides. An efficient method for the synthesis of 1,2,3-triazole bridged glycoconjugates with potential biological activity is described and fully supported with the 1H and 13C NMR spectroscopy of novel products. Chapter 4 is a comprehensive review of isocyanide-based cycloaddition reactions. This functionality is highly reactive and participates in many different cycloaddition reactions and annulations. Employment of isocyanide cycloaddition reactions led to the preparation of diverse heterocyclic structures, including asymmetric ones and their applications in medicinal chemistry, in the agricultural, chemical, and supramolecular fields, as well as in the materials sciences. Chapter 5 gives a review of the synthesis of 1,5-benzodiazepine-2,4-dione derivatives via 1,3-dipolar cycloaddition reactions. Functionalization of 1,5-benzodiazepine-2,4-dione by the cycloadditions of nitrilimines, nitrile oxides or azides led to diverse heterocyclic substitutions at positions 1, 3 and 5. Molecular structures of novel products were confirmed by X-ray crystal structure analyses. Chapter 6. Nitrile imines, nitrile oxides and azides were employed in 1,3-dipolar cycloaddition reactions with allyl and propargyl substituted 1,5-benzodiazepine, quinoxaline-2-thiones, benzimidazole and isatin to afford derivatives with heterocylic substituents: pyrazol, isoxazol and triazol. Single crystal X-ray studies of novel products were described, and their biological activity was also reported. Chapter 7. Guanidines are commonly occurring in nature and constituents some natural products with cyclic structures. Various cycloaddition reactions leading towards cyclic guanidine structures were reviewed. The review also summarized cycloaddition reactions in which functionalized guanidines were acting as the reaction partners.
|Author||: Thomas F. DeRosa|
|Publisher||: John Wiley & Sons|
|Release Date||: 2008-09-16|
|ISBN 10||: 0470385987|
|Pages||: 760 pages|
The objective of this book is to convey to academic and industrial researchers and students advances in synthetic and characterization methods in 9 selected areas of polymer chemistry reported in 2007-2008 US Patents. It reviews the impact of newer bulk anionic, cationic, and free radical polymerization methods within selected industrial applications. Bulk and surface crosslinking agents using selected bi- and tri-functional reagents, photochemical methods, or free radical agents are also reviewed. Finally, there is a separate section on cationic and cationic ring opening polymerization reactions describing di- and tri-heterocyclic monomers and their use in medical devices.
Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 21 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review "Biocatalytic approaches to chiral heterocycles" and "Ring-expanded (‘fat’) purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics." As with previous volumes in the series, Volume 21 apprises academic/industrial chemists and advanced students of developments in heterocyclic chemistry in a convenient format. * Covers the heterocyclic literature published in 2008 * Includes specialized reviews * Features contributions from leading researchers in their fields
|Release Date||: 2013-06-21|
|ISBN 10||: 1481673491|
|Pages||: 300 pages|
Biogenic Amines—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Biogenic Monoamines. The editors have built Biogenic Amines—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biogenic Monoamines in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Biogenic Amines—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
|Author||: Om Silakari|
|Release Date||: 2018-06-11|
|ISBN 10||: 0081021054|
|Pages||: 436 pages|
Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases